The Department of Oncological Sciences is composed of rigorous investigators from a variety of dynamic disciplines who are focused on revealing the genetic, biochemical, cellular, and physiological underpinnings of cancer. Situated within the Icahn School of Medicine at Mount Sinai, we are committed to discoveries which improve diagnosis and treatment, and we train the next generation of scientists with the skills they need to continue this critical work.

The Department of Oncological Sciences aims to achieve a molecular understanding of the cellular processes and signaling pathways involved in the initiation and progression of human cancers, as well as insights into molecular targets for innovative therapeutics.

Our current research themes encompass signaling pathways involved in cancer; oncogenes and tumor-suppressor genes; cell cycle regulation, tumor invasion and metastasis; regulation of protein stability; tumor microenvironment (including inflammation, angiogenesis, and lymphangiogenesis); cancer immunology; and novel cancer therapeutics and resistance mechanisms.

Through our research efforts, the Department of Oncological Sciences works to minimize the impact of cancer and advance patient outcomes within and beyond the Mount Sinai Health System.