Current VA Merits

Stella Dracheva
Serotonin 2C Receptor mRNA Editing in Suicide

VA Merit
2008-2012
In our previous studies we have detected increased mRNA editing of the serotonin 2C receptor (5-HT2CR) in suicide subjects who had suffered from either Schizophrenia (SZ) or Bipolar Disorder (BPD) prior to death. This difference may have a profound implications on the functionality of the serotonergic system in the brains of suicides. The current study aims: 1) To elucidate molecular mechanisms underlying this increased 5-HT2CR editing in suicide in the context of SZ and BPD; 2) To investigate whether suicide in the context of Major Depression is associated with variations in editing similar to those detected in SZ and BPD suicide victims.

Gregory Elder
Neurobiological Consequences of Blast Injury in a Rat Model of mTBI

VA Merit
2009-2012
The goal of this project is to using a rat model of blast related traumatic brain injury (TBI) determine whether blast injury damages brain structures that are important in mediating responses to psychological stressors and thus enhances the likelihood of developing post-traumatic stress disorder (PTSD) type traits when exposed to subsequent stressors.
Dates of Proposed Project: 7/1/2009-6/30/2012
Annual Direct Costs: $250,000
Percent Effort/Person Months: 3.6 calendar months

Mechanisms Underlying the Vascular Pathology of Alzheimer's Disease
VA Merit
2009-2012

Samuel Gandy, MD, PhD
Alzheimer Mouse Model for Intraneuronal Amyloid-Beta Oligomer Biology

VA Merit
2009-2012

Melissa Garrido, PhD
Impact of Mental Illness on Veterans' Palliative Care Access and Outcomes

VA Merit
2012-2015

Julia Golier, MD
Novel Therapeutics in PTSD: A Randomized Clinical Trial of Mifepristone
CSRD
2011-2015

Marianne Goodman
High Risk Suicidal Behavior in Veterans- Assessment of Predictors and Efficacy of Dialectical Behavior Therapy

Department of Army
2009-2013
This study aims to empirically test the efficacy of dialectical behavioral therapy relative to treatment as usual in the prevention of suicidal behavior and intermediate symptoms associated with suicidal behavior.

Erin Hazlett
Selecting Best Neuroleptic Treatment for Veterans with Schizophrenia

VA Merit
2011-2015
The purpose of this study is to translate basic and clinical research into innovative clinical assessment by utilizing functional and structural brain imaging and psychophysiology to predict response to risperidone in veterans with schizophrenia.

Effie Mitsis, PhD
Imaging and Cognitive Correlates of Blast TBI in OIF/OEF Combat Veterans

Merit
2008-2012

Antonia New
High Risk Suicidal Behavior in Veterans- Assessment of Predictors and Efficacy of Dialectical Behavior Therapy

Department of Army
2009-2013
This study aims to empirically test the efficacy of dialectical behavioral therapy relative to treatment as usual in the prevention of suicidal behavior and intermediate symptoms associated with suicidal behavior.

Giulio M. Pasinetti
The Role of Energy Metabolism in the Prevention of Alzheimers Disease

Merit
2008-2012

Mechanisms of BACE1 Degradation in Experimental Alzheimer's Disease Therapeutic
Merit
2010-2014

Mary Sano, PhD
Markers of Transition to Alzheimer Disease in Veterans with MCI

VA Merit
2011-2115

Larry Siever, MD
White Metter Abnormalities in the Schizophrenia Spectrum
VA Merit
2012-2016
The purpose of this study is to investigate whether variations in specific genes related to the schizophrenia spectrum of disorders, including schizophrenia and schizotypal personality disorder (SPD), are associated with changes in brain functioning.

Jeremy M. Silverman
A Genetic Study of Schizophrenia in Puerto Rico

ID: 1062
Merit
2008-2012

Ruth Walker
The Role of H2 Field of Forel/Zona Incerta in PD Neurosurgical Therapy

VA Merit
2008-2012
Deep brain stimulation of the subthalamic nucleus (STN) has become state-of-the-art therapy for patients with Parkinson's disease (PD) who no longer respond adequately to optimal medical therapy. However, the ideal target site for electrode placement remains a subject of debate. Clinical studies examining the placement of the most effective STN stimulating electrode contacts suggest that the region dorsolateral to the STN, which includes the H2 field of Forel (H2) and the zona incerta (ZI), may be the best target site. This project studies the effects of lesions and stimulation of the H2/ZI in the rat model of PD upon motor behaviors and brain neurochemistry.

Rachel Yehuda
Neural and Cognitive Correlates of Glucocorticoid Responsiveness in PTSD

VA Merit
2008-2012


Contact Us

Tel: 212-659-8734

Icahn School of Medicine
Department of Psychiatry
Box 1230
One Gustave L. Levy Place
New York, NY 10029