With over $247M in NIH funding, Icahn School of Medicine at Mount Sinai has a large cadre of investigators conducting ground-breaking research. The laboratories focus on both basic science and translational research, and aim to improve diagnostic and therapeutic approaches to medical care.


Name Description
CancerGenetics Aaronson Laboratory The Aaronson laboratory is involved in cancer gene discovery and function with the goal of identifying novel targets for therapy Stuart A Aaronson
HIV Aberg Laboratory HIV-related opportunistic infections, vaccine response, and complications of HIV disease, including studies of the pathogenesis of inflammation that contributes to the co-morbidities associated with the aging of those with HIV infection. Judith A Aberg
Genomic medicinePersonalized medicine Abul-Husn Laboratory Translating genomic medicine into clinical care Noura S Abul-Husn
Signaling and metastasis Aguirre-Ghiso Laboratory Studying various aspects of signaling and metastasis Julio A Aguirre-Ghiso
Arrhythmia Akar Laboratory Investigating arrhythmia mechanisms in structural heart disease at multiple levels of integration Fadi Akar
Genetic psychiatryGenetic pathology Akbarian Laboratory Exploring the genome within human brain cell nuclei, including potential alterations in psychiatric diseases Schahram Akbarian
Autoimmunity Alexandropoulos Laboratory Studying the role of leukocytes with emphasis on T cells in the development of autoimmune diseases and chronic inflammation Konstantina Alexandropoulos
Liver researchImmunology Liver cancerHepatitis C Andrea Branch Laboratory Hepatitis C virus, development of hepatocellular carcinoma (liver cancer), and the immunobiology of the human liver Andrea D Branch
Ocular Health Asbell Laboratory Researching diagnosis and treatment of ocular diseases, conditions, and injuries
Viral infection Ashour Laboratory Studying virus interactions with B-cells Joseph Ashour
NeuroscienceMotivated behaviors Avena Laboratory Focusing on translational research modeling disordered eating behaviors, as well as drug use Nicole Avena-Blanchard
Tissue engineeringSystems pharmacologyBiomechanics Azeloglu Laboratory Systems-level study of mechanobiology and biomechanics Evren U Azeloglu
Bakel Laboratory Researching transcription regulation; coding/non-coding RNA biology; and genome architecture, particularly within infectious disease Honoratus Van Bakel
Radio frequency; magnetic resonance imaging Balchandani Laboratory Designing radio frequency pulses and pulse sequences via high-field magnets; exploiting new contrast mechanisms for novel MRI applications Priti Balchandani
Liver researchLiver disease Bansal Laboratory How HIV promotes liver inflammation and fibrosis through interactions with both activated hepatic stellate cells (HSCs) and liver macrophages (Kupffer cells) Meena B Bansal
Cellular biology in miceGeneticsGrowth and development Baron Laboratory Researching hematopoietic and vascular development in mice; regulation of stem cell proliferation, survival, and differentiation; gene regulation; primitive and definitive endodermal lineages; and angiogenesis Margaret H Baron
Genomics Bashir Laboratory Investigating various complications in genomic architecture Ali Bashir
Microbiology Basler Laboratory Investigating the molecular determinants of virulence of emerging viruses, focusing on the pathogenic Ebola and Marburg viruses Christopher F Basler
Neuroscience Baxter Laboratory Using animal models to establish causal links between manipulations of defined neural circuits, behavioral and cognitive functions Mark Baxter
RNAGeneticsBiochemistry Bechhofer Laboratory Description Focusing on mechanism of RNA processing, particularly messenger RNA decay in gram-positive bacterium David H Bechhofer
HIVVirological synapses Benjamin Chen Laboratory Exploring complex cellular and molecular interactions promoting viral replication and immune cell depletion in HIV Benjamin K Chen
Neuroscience Benson Laboratory Investigating mechanisms required to generate normal functioning neural circuits Deanna L Benson
Food allergy Berin Laboratory Researching the immune basis of food allergy; control, suppression, and amplification of immunity M. Cecilia Berin
Regenerative healingCell and tissue biology of the eye Bernstein Laboratory (Audrey) Studying the regulation of cellular pathways that lead to scarring in the eye and glaucoma. Audrey M Bernstein
Chromatin Bernstein Laboratory (Emily) Our focus is on epigenetic regulation of gene expression in multiple biological pathways including cancer, cellular senescence and stem cell biology Emily Bernstein
Cell biology Bhardwaj Laboratory Focusing on combining fundamental research in dendritic cell biology with innovative translational and clinical approaches Nina Bhardwaj
Molecular biology Bieker Laboratory Researching transcriptional regulation of red-cell-specific gene expression James J Bieker
CancerComputational systems biologySystems biologyCell biologySystems pharmacologySignal Transduction Birtwistle Laboratory, Cancer Systems Biology Studying translations of mammalian cellular signaling into both single-cell and population level phenotypic behavior to advance engineering and medicine Marc Birtwistle
Memory; rodent hippocampus Blitzer Laboratory Researching regulation of translation in long-term potentiation mechanisms of normal memory formation, and underlying pathology of memory impairment Robert D Blitzer
Microbiology Bogunovic Laboratory Investigating human immune system using immunogenomic, molecular biology, cellular biology, immunology and clinical tools Dusan Bogunovic
Bone lead x-ray Bone Lead X-Ray Fluorescence Laboratory Practicing X-Ray fluorescence to measure long-term or cumulative lead exposure in human bone; one of only two centers nationwide to do this Andrew C Todd
Microbiology Bouvier Laboratory Researching viral factors in respiratory influenza transmission Nicole M Bouvier
Gene therapyBrain tumors Brain Tumor and Gene Therapy Laboratory Investigating new delivery methods for pro-apoptotic genes while sparing normal brain cells; effects of substances to enhance standard treatments Isabelle M Germano
Schizophrenia Brennand Laboratory Studying schizophrenia by reprogramming skin samples into pluripotent stem cells, later differentiated into human neurons Kristen Brennand
Dendritic cellsCancer vaccinesCheckpoint blockadeLymphomaCancer immunotherapy Brody Lab The Brody Lab studies novel approaches to initiate and increase adaptive immune responses against cancer. These include combinations of checkpoint blockade approaches, discovery of novel tumor immune evasion checkpoints, in situ vaccine strategies using Flt3L to mobilize dendritic cells (DC), cytotoxic therapy to induce immunogenic cell death and load DC with tumor-associated antigens, and DC activators such as TLR and other PRR agonists. A primary focus is on strategies with potential for near-term translation to the clinic, with an emphasis on lymphoid malignancies including lymphoma and CLL. Joshua Brody
AutoimmunityGeneticsCellular BiologyMicrobiology Brown Lab Exploring microRNA biology; biotechnology; immunology; gene therapy; autoimmune disease; and molecular regulation Brian D Brown
Spinal cord injury Bryce Laboratory Conducting research addressing the challenges of traumatic spinal cord injury, or SCI Thomas N Bryce
Insulin actionAlcoholismNeuronal control autonomic nervous systemObesityAlzheimer's DiseaseMetabolismDiabetes Buettner Laboratory Brain control of metabolism and innate immunity Christoph Buettner
Systems biologyAllergiesAsthmaIntegrative genomics Bunyavanich laboratory Integrative genomics of asthma and allergic disorders Supinda Bunyavanich
Psychiatric diseasesNeurological diseases Buxbaum Laboratory The laboratory of Molecular Neuropsychiatry studies human psychiatric and neurological diseases using the methods of genetics, genomics, cell and molecular biology and animal models. Current laboratory focus includes autism, schizophrenia and Alzheimer's disease. Joseph D Buxbaum
CancerDiabetes Cagan Laboratory Undertaking a genetic and drug screening approach to target cancer and diabetes, using the Drosophila fruit fly Ross L Cagan
NeurologyNeurodegenerative diseaseNeuroscienceAlzheimer's DiseaseAging Cai Laboratory Our research program has been focused on studying the regulation of brain phospholipid composition and metabolism in Alzheimer's disease (AD) pathogenesis. Using transgenic animal models and postmortem human brain tissue, we investigate the molecular and cellular mechanisms underlying disease development and progression, with the goal of developing novel therapeutic strategies for AD. Dongming Cai
Hippo pathway signalingExperimental glomerular diseasePodocyte cell biology Campbell Laboratory Defining novel mediators of kidney podocyte injury and survival in the quest for targeted therapeutics in glomerular disease. Kirk Campbell
Oncology Cancer Prevention and Control Division Researching safer and more effective cancer treatments William H ReddPaolo Boffetta
Ocular Health Candia Laboratory Focusing on characterization of basic physiological phenomena in ocular epithelia, related to membrane permeability, ionic and fluid transport Oscar A Candia
Cardiovascular physiology and imaging Cardiovascular Translational Laboratory of Physiology and Imaging Performing as a conventional cardiac catheterization laboratory for animal research, identical to human labs Roger J Hajjar
Neuroscience Casaccia Laboratory Integrating state-of-the-art technologies, animal models, and drug discovery to promote a center of excellence for Myelin repair Patrizia Casaccia
Chinese herbal medicine Center for Chinese Herbal Therapy Researching traditional Chinese medicine, including herbal medicines and acupuncture, for treatment of asthma, food allergies, and atopic dermatitis Xiu-Min Li
Cerebrovascular health Cerebrovascular Laboratory Studying cerebral injury during the first 48 hours after subarachnoid hemorrhage Fatima A Sehba
Cardiology Chaudhry Laboratory Focusing on cell cycle regulation of cardiomyocytes and endogenous progenitor cells in the heart Hina Chaudhry
CancerGenomicsBioinformaticsPersonalized medicine Chen Laboratory Exploring the use of clinical genome informatics Rong Chen
GenomicsNeuroscienceHuman biology Chess Laboratory Studying unusual mechanisms involved in regulating gene expression Andrew Chess
Cancer Chipuk Laboratory The focus of our laboratory is to explore how mitochondria impact on human health and disease Jerry Chipuk
Genetics; IBD Cho Laboratory Investigating genetic and immunologic factors associated with Crohn’s Disease and ulcerative colitis (inflammatory bowel diseases) Judy H Cho
Cancerp53ZebrafishDevelopmentMetabolism Chu Laboratory The Chu lab is focused on using zebrafish to study sugar metabolism, p53, and cell proliferation in early development and cancer. Jaime Chu
Nephrology Chuang Laboratory Working to elucidate the cellular mechanism of Foxo transcription factor activation in podocytes LING-SHIANG CHUANG
Neuropsychology Clark Laboratory Investigating cognitive and affective impairment through
Emotional brain plasticity Clem Laboratory Using molecular and electrophysiological approaches, including optogenetic stimulation, to identify impact of associative fear conditioning on neural pathways and neurons in limbic and cortical regions Roger Clem
Microbiology Clemente Laboratory Developing computational methods to better understand the microbial world Jose C Clemente Litran
Renal disease Clinical and Translational Research Unit in Nephrology Biomarkers, Clinical Trials and Quality Improvement in Nephrology Steven G Coca
Cognitive psychophysiology Cognitive Psychophysiology Laboratory Conducting multidisciplinary research using neuroimaging and psychophysiological measures to study cognition and emotion Erin A Hazlett
Cell biologyCardiology Costa Laboratory Researching biomechanics of cardiovascular cell and tissue function in healthy and diseased states Kevin Costa
Traumatic brain injuryAlzheimer's DiseaseNeurodegenerationNeuropathology Crary Laboratory The Crary Laboratory uses classical histopathological, genetic and cellular approaches to advance our understanding of the pathogenesis of the neurodegerative tauopathies. The laboratory focuses on primary age-related tauopathy, traumatic brain injury and their relationships to classical Alzheimer’s disease. John F Crary
Neuroscience Cropper Laboratory Studying neural mechanisms of sensorimotor integration Elizabeth Cropper
Neuroscience Croxson Laboratory Investigating memory governing networks across different regions of the human brain Paula Croxson
Immunodeficiency Cunningham-Rundles Lab Investigating B, T cell and dendritic cell immunity in primary immunodeficiency diseases Charlotte Cunningham-Rundles
Signal Transduction Dar Laboratory The study of signal transduction networks at multiple levels: structurally, biochemically, within cells, and also within whole animals Arvin Dar
AutoimmunityThyroid Davies Laboratory Researching various aspects of thyroid autoimmune disease Terry F Davies
Pharmacology DeVita Laboratory Researching drug discovery and development Robert J DeVita
Neurology Devi Laboratory Researching molecular mechanisms in neurology Lakshmi A Devi
Health psychology Diefenbach Laboratory Exploring psychological, social, and medical factors influencing health behavior decisions Michael A Diefenbach
CancerDrug discoveryGene regulationDrug resistanceCancer genetics Domingo-Domenech Laboratory Study of mechanisms of aggressiveness and resistance to therapy in cancer. Josep M Domingo-Domenech
OncogenesEarly B cell Lymphomagenesis Dominguez-Sola Laboratory Understanding the early steps of B cell lymphomagenesis David Dominguez-Sola
Stem cellsCardiology Dubois Laboratory Using the human pluripotent stem cell model to investigate cellular and molecular mechanisms of cell fate specification and disease in the early human heart Nicole C Dubois
Translational and biomedical informatics Dudley Laboratory Focusing on translational and biomedical informatics approaches to address critical challenges in systems medicine Joel Dudley
Neuroscience Ellis-Davies Laboratory Researching optical methods and neurophysiology Graham Ellis-Davies
Microbiology Evans Laboratory Investigating host pathogen interactions that affect viral tropism and disease outcome, with a focus of those of the hepatitis C virus Matthew J Evans
Digestive microbiology Faith Laboratory Applying experimental and computational tools to understand interactions between diet, the microbiota, and human health Jeremiah Faith
GenomicsEpigenomics Fang Laboratory Identifying disease mechanisms that may lead to improved diagnosis and treatment Jeremiah Faith
Cardiovascular Imaging Fayad Laboratory Conducting multi modality cardiovascular imaging Zahi A Fayad
Neurology Felsenfeld Laboratory Investigating regulation of L1-CAM-mediated traction force during neuronal growth
Viral Immunity Fernandez-Sesma Laboratory Investigating the mechanisms of viral immune evasion Ana Fernandez-Sesma
Pharmacology Filizola Laboratory Engaging in compter-aided structural bio and drug design Marta Filizola
Cell biology Fisher Laboratory Exploring intricate processes of cell division Robert P Fisher
Hepatic stellate cellsHepatic carcinogenesisChronic liver diseaseHepatic autophagyHepatic fibrosis Friedman Laboratory Exploring links between hepatic autophagy, fibrosis and progenitor cell amplication; bioinformatics assessment of stellate cell biology; studying pathogenesis of hepatic fibrosis, testing of antifibrotic therapies. Scott L Friedman
Diabetes and cancerCholesterol metabolism and cancerMetabolic syndrome and cancerHyperinsulinemia and cancerBreast cancer Gallagher Laboratory The focus of the lab is to understand the links between obesity, type 2 diabetes and breast cancer progression, with a specific interest in the roles of cholesterol, cholesterol metabolites. Emily J Gallagher
Neural pharmacology Gallo Laboratory, Systems Pharmacology of Brain Tumor Chemotherapy Researching brain tumors; neuro pharmacology; and chemotherapy James M Gallo
Microbiology García-Sastre Laboratory Exploring virus-host interactions Adolfo Garcia-Sastre
Gastrointestinal cancer Gastrointestinal Cancer Research Laboratory Researching gastrointestinal cancer Steven H Itzkowitz
Genetic testing Genetic Testing Laboratory Studying methods and applications of genetic testing Lisa J Edelmann
Mitochondrial UPRPregnancy-Associated Breast Cancer Germain Laboratory Our laboratory focuses on the role of mitochondrial unfolded-protein response (UPRmt) in breast cancer Doris Germain
NeurologyNeurosurgery Germano Laboratory Germano Laboratory, Neurosurgery, Oncological Science, Neurology, Brain Tumors Isabelle M Germano
Cell biology Ghaffari Laboratory Elucidating regulatory signals in stem cell fate and mechanisms of alterations in disease Saghi Ghaffari
AddictionAlzheimer's DiseaseDementia Goate Laboratory Research in our laboratory focuses on dementia (Alzheimer's disease & frontotemporal dementia) and addiction (alcohol dependence) Alison M Goate
Molecular pharmacology Gonzalez-Maeso Laboratory, Molecular Pharmacology Gonzalez-Maeso Laboratory, Molecular Pharmacology, Psychiatry Javier Gonzalez-Maeso
Liver disease Gouon-Evans Laboratory Investigating liver development and regeneration Valerie Gouon-Evans
Rheumatoid ArthritisAutoimmune Diseases Gulko Laboratory Discovering new genes implicated in (RA), identifying prognostic biomarkers and generating new targets and more effective therapies to cure RA and other autoimmune diseases Percio S Gulko
Dermatology Guttman Laboratory Inflammatory skin diseases Emma Guttman
Medical-epigenetics Haghighi Laboratory We investigate epigenetic changes in disease and normal human postmortem brain samples, providing a snapshot of potential epigenetic abnormalities associated with disease neuropathology Fatemeh Haghighi
Familiar cardiovascular research Hajjar Laboratory (Wiener Family Cardiovascular Research Laboratories) Concentrating on gene therapy for heart failure and other cardiovascular diseases
NeurophysiologyAlcoholismDepression Han Laboratory Exploring neurophysiology as it relates to depression and alcoholism Ming-Hu Han
Kidney fibrosisNephrologyKidney diseaseKidney podocyte injuryDiabetic nephropathyCell signaling He Laboratory Investigating role of retinoic acid in podocyte biology and pathology; Role of HIPK2 in kidney fibrosis; Using systems biology approach to study kidney disease; Pathogenesis of HIV-Associated Nephropathy; Pathogenesis of diabetic kidney disease John Cijiang He
Heeger Laboratory Translational research in the field of transplantation biology Peter S Heeger
Neuroscience Hof Laboratory Conducting neuromorphology research Patrick R Hof
Neurobiology Holstein Laboratory Identifying the neurobiological bases for disorders of balance, equilibrium, and movement Gay Holstein
Liver disease Hoshida Laboratory Researching chronic liver disease through genomics; clinical diagnostics; chemical biology; biostatistics; and informatics Yujin Hoshida
Genetics and genomicsMicrobiology Hu Laboratory Focusing on the role of microbiota and host genetics in disease pathogenesis Jianzhong Hu
Orthopaedics Huang Laboratory Researching molecular and mechanical regulation of stem cell induction and differentiation during fibrous connective tissue healing and regeneration Alice H Huang
PharmacogenomicsPersonalized therapeutics Hulot Laboratory Investigating pharmacogenomics and personalized therapeutics Jean-Sebastien Hulot
Humans in aerospace Human Aerospace Laboratory Studying the effects of spaceflight on neurological function in humans Steven T Moore
NeurologyOtolaryngology Human Balance Laboratory Our research has been focusing on the treatment for mal de debarquement syndrome (MdDS) and on reducing motion intolerance, including visual intolerance. Mingjia Dai
Neuroscience Huntley Laboratory Researching synaptic circuit development, and neural plasticity George W Huntley
AddictionMolecular neuropsychopharmacology Hurd Laboratory Studying the neurobiology of underlying drug abuse and related psychiatric disordersy Yasmin Hurd
Tissue engineeringBiomechanicsMechanobiology Iatridis Laboratory Developing minimally invasive interventions to prevent and repair painful intervertebral disc pathologies James C Iatridis
Multiple sclerosis Inglese Laboratory Investigating the pathological pathways of multiple sclerosis Matilde Inglese
GeneticsGenomics Ioannou Lab Researching Niemann-Pick disease; NPC1L1; and lysosomal proteomics/lipodimics
Cell and tissue biology of the eye Iomini Laboratory Understanding cilia-mediated signaling in eye development, repair and diseases Carlo Iomini
Breast cancer Irie Laboratory Focusing on role of oncogenes, such as Akt regulate processes, in breast cancer; identifying novel regulators of anoikis resistance for novel therapeutic targets in breast cancer treatment Hanna Y Irie
Systems biologySystems pharmacology Iyengar Laboratory, Systems Pharmacology and Systems Biology Exploring how signals are routed and processed through cellular signaling networks, including information sorting and integration mechanisms Srinivas (Ravi) Iyengar
Genetics Jabs Laboratory (Ethylin Wang Jabs) Researching molecular basis of human malformation disorders including craniosynostosis, oral clefting, limb disorders and syndromes Ethylin W Jabs
CommunityColon oncology Jandorf Laboratory Aiming to reduce cancer-related health disparities across genders and disease sites Lina H Jandorf
Jin Laboratory
Multiple sclerosisNeurobiology John Laboratory for Multiple Sclerosis Studying mechanisms controlling lesion formation and repair in inflammatory diseases of the central nervous system Gareth R John
Neuroimaging Junqian Xu Laboratory Developing advanced magnetic resonance techniques to study neurological and psychiatric disorders Junqian Xu
OncologyGynecologyendometriosis Kalir Laboratory Our Lab investigates gynecologic precancers and cancers, with the goal of unraveling the secrets of carcinogenesis and, identifying prognostic biomarkers to improve therapeutics. Specific areas we have studied include: i) predictive markers of endometriosis giving rise to ovarian endometrioid and clear cell cancers, and ii) prognostic and therapeutic value of nuclear pore protein NUP62 and nuclear transport protein CRM1 in ovarian high-grade serous carcinomas. Tamara L Kalir
Neuroscience Kaplan Laboratory Exploring information processing in the nervous system, using the visual system as a model Ehud Kaplan
Systems biology Karr Laboratory Developing predictive, dynamical models of biological systems for bioengineering and precision medicine Jonathan Karr
Cardiovascular Kawase Laboratory Focusing on large animal models of arrhythmia caused by ischemic cardiomyopathy Yoshiaki Kawase
Medical genomics Kenny Laboratory Analyzing human genetic variation to address fundamental questions in biology, medicine, and anthropology Eimear Kenny
Behavioral and molecular neuroscience Kenny Laboratory (Paul J. Kenny), Behavioral and Molecular Neuroscience Researching applications in behavioral and molecular neuroscience Paul J Kenny
Cardiovascular Kovacic Laboratory Exploring arteries of the heart; atherosclerosis, fibromuscular dysplasia, and other cardiovascular diseases Jason C Kovacic
VirologyVaccinology Krammer Laboratory Developing broad and effective vaccines against viral pathogens Florian Krammer
Developmental and degenerative biology Krauss Laboratory Studying pattern formation and cell differentiation during development and tissue regeneration Robert S Krauss
Cell biology Krulwich Laboratory Studying ion-translocating membrane transporters in bacterial cells Terry A Krulwich
Functional MRINeuroimaging Kundu Laboratory Developing neuroimaging and functional MRI techniques to study healthy and pathological brain function Prantik Kundu
Clinical lab work Laboratory Medicine Offering an extensive set of routine and complex tests for accurate diagnoses and optimal treatment plans
Genetic neurodegenerationMolecular biology Laboratory of Molecular Biology and Genetics of Neurodegeneration, Robakis Laboratory Researching the roles and processes of molecular biology and genetic neurodegeneration in specific diseases Nikolaos K Robakis
PharmacologySignal TransductionBiochemistryStructural and computational biology Lazarus Laboratory Studying energy homeostasis in disease using chemical biology Michael Lazarus
ObesityInsulinCancer researchDiabetes LeRoith Laboratory Understanding the role of insulin and insulin-like growth factors in health and disease, including the factors which explain the increased risk of cancer, especially triple negative breast cancer, and cancer-related mortality in obesity and type 2 diabetes Derek LeRoith
Cardiac physiology Lebeche Laboratory Targeting molecular and cellular pathways to improve contractile function and survival in failing cardiac myocytes Djamel Lebeche
PathogenesisMolecular virology Lee Laboratory Exploring how viruses co-opt basic cell biological processes, and the myriad strategies used by viruses to propagate themselves Benhur Lee
Integrative stem cell biology Lemischka Laboratory Researching molecular and cellular nature of the undifferentiated stem cell states, and how they are altered during a change in cell fate Ihor R Lemischka
Prostate cancer Levine-Kirschenbaum Laboratory Investigating the mechanism underlying the predilection of prostate cancer to metastsize to bone. Alice C LevineAlexander Kirschenbaum
Cardiovascular health Li Laboratory (Cardiovascular Research Center) Developing cell- and gene-based approaches for heart regeneration Ronald Li
Developmental and regenerative biology Li Laboratory (Department of Developmental and Regenerative Biology) Analyzing the acquisition and maintenance of genomic DNA methylation imprints in mice, as well as in ES and iPS cells Xiajun (John) Li
Life science technology Life Science Technology Laboratory Focusing on GeneProfiler, Pathway Assist, Affymetris Gene Chip and Chip on Chip
Immunology GeneticsVirologyin vivo and ex vivo modeling of infection Lim Laboratory Studies the cellular immune response to vector-transmitted viruses, such as West Nile virus, Zika virus, and tick-borne encephalitis virus. We focus primarily on how cytokine responses and cell trafficking events affect the pathogenesis of these viruses. Jean K Lim
Linden Laboratory Linden Laboratory
Mucosal Immunology Lira Laboratory We study the mechanisms whereby specific immune molecules (cytokines and chemokines) affect the function of the epithelial, immune, endothelial, and stromal cells from the intestine in health and disease. Sergio Lira
Liver cancer Llovet Laboratory Primary Focus on understanding the molecular pathogenesis of liver cancer, generating a genomic classification and discovering novel targets for more effective therapies Josep Llovet
Lujambio Laboratory Amaya Lujambio Goizueta
Computational systems biologySystems biologyGenomicsSystems pharmacologyBioinformatics Ma'ayan Laboratory, Computational Systems Biology Applying computational and mathematical methods to study the complexity of regulatory networks in mammalian cells Avi Ma'ayan
Developmental and regenerative biology Mani Laboratory Translating novel multi-modality imaging techniques for use in multicenter clinical trials
Transcription regulationEpigeneticsMicrobiology Marazzi Laboratory Epigenetic and chromatin-mediated control of gene expression in the context of cellular response to pathogens or cellular differentiation Ivan Marazzi
ProteomicsAlzheimer's Disease Mass Spectrometry Proteomics Laboratory Utilizing biological mass spectrometry to probe protein interactions and processing mechanisms of amyloid beta-protein in Alzheimer's disease Rong Wang
Cell biology Masur Laboratory Researching cell adhesion and extracellular matrix; extracellular matrix; proteases; receptors; and signal transduction
Neuroepigenetics Maze Laboratory Chromatin regulatory mechanisms of neural plasticity and disease Ian S Maze
Dendritic cellsMicrobiomeMucosal Immunology Mehandru Laboratory Regulation of the host-environmental interface by mucosal dendritic cells and targeting mucosal dendritic cells at steady state and during inflammation. Saurabh Mehandru
Immunity Merad Laboratory Studying regulatory mechanisms of dendritic cells and macrophages, related to immune response against pathogens and tumor cells in vivo Miriam Merad
CancerMetabolic diseaseDiabetes Metabolic Mechanisms of Diabetes and Cancer Laboratory Researching insulin and insulin-like growth factors in disease states
Structural and computational biology Mezei Laboratory Computer simulation of aqueous systems; methodology and biomolecular applications Mihaly Mezei
Microscopy Microscopy CORE High-end instrumentation for bright field and fluorescence microscopy and to computer workstations for image processing, image deconvolution, and image analysis Deanna L Benson
Cell biology Migliaccio Laboratory Researching pathobiology of primary myelofibrosis, as well as transfusion processes Anna R Migliaccio
Cell biology Mlodzik Laboratory Studying Wnt/Frizzled-planar cell polarity signaling, associated regulatory and signaling specificity mechanisms Marek Mlodzik
Neurology Mobbs Laboratory Researching the role of aging in obesity, diabetes, and Alzheimer's Charles V Mobbs
Molecular biology Molecular Biology Core Laboratory Providing services in response to clinical research needs of both established and new CRC investigators George A Diaz
CancerBehavior Montgomery Schnur Laboratory Our research explores the use of mind-body and complementary medicine interventions for symptom and side-effect control – such as reducing pain, nausea, and fatigue. Guy H MontgomeryJulie B Schnur
Immunity during pregnancyViral infectionVirus bacterial co-infection Moran Laboratory Studying translations of mammalian cellular signaling into both single-cell and population level phenotypic behavior to advance engineering and medicine Thomas M Moran
Neurology Morishita Laboratory Studying developmental brain plasticity and cognition Hirofumi Morishita
Nanomedicine Mulder Laboratory Researching translational and molecular imaging Willem J Mulder
Network modeling Multiscale Network Modeling Laboratory Focusing on construction and characterization of multiscale biological networks, from large-scale genomic, genetic, epigenetic, proteomic and clinical data Bin Zhang
GenomicsRenal FibrosisTransplant genomics Murphy Laboratory Investigating genetic and genomics in risk stratification in organ transplantation; renal fibrosis in Chronic Kidney Disease and Chronic Allograft Injury Barbara Murphy
Molecular psychiatry Nestler Laboratory Studying molecular mechanisms of addiction and depression Eric J Nestler
Neuroanatomy and morphometrics Neuroanatomy and Morphometrics Laboratory Examining the relationship between brain structure and function in health and disease William M Byne
Neurobehavioral genetics Neurobehavioral Genetics Laboratory Identifying the genetic basis of complex neuropsychiatric phenotypes through a multifaceted approach, including sophisticated gene expression technologies L. Alison McInnes
Neurobiology Neurobiology of Aging Laboratories Exploring age-related alterations in brain function John H Morrison
Neuroimaging Neuroimaging Laboratory Focusing primarily on functional magnetic resonance imaging, diffusion tensor imaging, and structural imaging Jin Fan
Neuropathology Neuropathology and Brain Banking Serving the human postmortem brain tissue needs of investigators at ISMMS
NeuropharmacologySystems biologySignal Transduction Neves Laboratory The Neves lab studies how cyclic nucleotide signaling in neurons affects synaptic responsiveness in both normal and disease states Susana Neves
CancerCell divisionCell cycleCell biologyCancer genetics O'Connell Laboratory Our research focuses on two related aspects of the biology that controls the integrity of the genome Matthew J O'Connell
Neuroimaging O'Halloran Laboratory Researching deep brain stimulation surgery to treat conditions such as Parkinson's disease, dystonia, and depression Rafael O'Halloran
Orthopaedics Orthopaedics Research Laboratory Using multidisciplinary approaches to address fundamental questions in the field of orthopaedic research James C Iatridis
Genetics Neurodegeneration Paisan-Ruiz Laboratory Elucidating and understanding the genetic etiology of Movement Disorders Coro Paisan-Ruiz
Virology Palese Laboratory Focusing on genetic make-up and biology of viruses, as well as virus-host interactions Peter Palese
F-box proteinsCullin 7CullinsBiochemistryDEN1 Processing Enzyme Pan Laboratory Ubiquitin signaling in cancer biology using biochemical, molecular biology and chemical biology approaches Zhen-Qiang Pan
Genomics Papapetrou Laboratory Exploring human pluripotent stem cells to understand the mechanisms of malignant and nonmalignant genetic blood diseases and to develop new therapies Eirini Papapetrou
Genomic medicinePersonalized medicine Parekh Laboratory Patient-focussed, systems biology approach towards studying the contribution of genetic and epigenetic variation to aberrant gene expression in B cell malignancies, particularly non-Hodgkins Lymphoma and Multiple Myeloma. Samir Parekh
Cancer research Parsons Laboratory Combining molecular pathology and genetic studies of human tumor biopsies, human and mouse tumor models, metabolism, epigenetics, and biochemistry of signaling Ramon Parsons
Neuroinflammation Pasinetti Laboratory Studying biology and treatment of destructive inflammatory mechanisms in the brain, often related to neurodegenerative disorders Giulio M Pasinetti
GeneticsCardiovascular diseasesMicrobiomeIBD Peter Laboratory Working to better understand the role of genetics and the microbiome in the development of complex diseases Inga Peter
CancerGene discoveryCell cycle checkpointsDrosophilaDevelopmental and regenerative biology Pfleger Laboratory Pursuing the study of two main pathways: (1) an emerging tumor suppressor pathway called the "hippo pathway" and (2) the ubiquitin pathway Cathie Pfleger
Genetics of neuropathology Pinto Laboratory Identifying genes and biological pathways involved in various neurodevelopmental disorders
Oncology Poulikakos Laboratory Studying kinase regulation and oncogenic signaling Poulikos Poulikakos
Lung cancer Powell Laboratory Studies genomics of lung cancer progression and of the tumor microenvironment Charles A Powell
Psychiatric neurocognition Psychiatric NeuroCognition Laboratory Exploring the neural basis of cognitive-emotional functioning in healthy individuals and those with obsessive-compulsive and related disorders Emily Stern
Psychopharmacology Psychopharmacology Laboratory Using rodent model systems for Alzheimer’s disease Vahram Haroutunian
PharmacologySystems therapeutics Ramirez Laboratory Characterizing multiple roles of extracellular matrix during vertebrate organogenesis, and in disorders of connective tissue Francesco Ramirez
CancerGenetics Reddy Laboratory Cancer gene discovery and function with the goal of identifying novel targets for therapy E. Premkumar Reddy
Stem cells Rendl Laboratory Utilizing genetic mouse models to uncover how specialized Dermal Papilla cells act as instructive niche cells for hair follicle stem cells Michael Rendl
Nuclear poresCell cycle checkpointsChromosomal instabilityCancer researchTherapeutic responses Rodriguez-Bravo Laboratory Study of genome integrity maintenance mechanisms during cell proliferation and the impact of nuclear pores and chromosomal defects on cancer cells aggressiveness and survival to current therapies. Veronica Rodriguez-Bravo
ApoptosisHIVKidneyInflammationChronic kidney disease Ross Laboratory The major focus of the work in the Ross lab is to identify novel mechanisms of kidney injury in HIV-positive patients. Michael J Ross
GenomicsNeuroepigeneticsBioinformatics Roussos Laboratory Explores the genetics of regulation of gene expression in neuropsychiatric diseases Panagiotis Roussos
Rudebeck Laboratory Exploring interactions between the prefrontal cortex and subcortical structures, related to emotional regulation and decision-making Peter H Rudebeck
Russo Laboratory Researching neuroplasticity and behavior Scott J Russo
Stem cellsEpigeneticsExosomesHeart failureGene expression Sahoo Laboratory Exosomes are naturally secreted nanovesicles that can shuttle fortified or diseased material from the cell of their origin to cells at the vicinity or at a distance. Recently, we have discovered that human stem cells secrete exosomes to mediate repair of a diseased heart by transferring their unique repertoire of miRNAs improving cardiac function and reducing fibrosis. We aim to harness the regenerative and communicative potential of stem cell-derived exosomes for novel therapeutic approaches. Our long-term goal is to artificially engineer these powerful nanovesicles for an off-the-shelf-product to treat patients with cardiovascular diseases. Susmita Sahoo
Neurology Salton Laboratory Investigating how neurotrophic growth factors, including nerve growth and brain-derived neurotrophic factors, regulate nervous system development and function Stephen Salton
Bioinformatics Sanchez Laboratory Working with structural bioinformatics to predict and analyze protein structure and function Roberto Sanchez
Neuroscience Schaefer Laboratory Identifying the epigenetic basis of neurodegenerative and psychiatric disorders
Stem cells Schaniel Laboratory Researching integrated stem cell biology; genomics; regenerative biology; and pharmacology Christoph Schaniel
Affective neuroscience Schiller Laboratory Discovering neural mechanisms underlying emotional control and flexibility Daniela Schiller
Systems pharmacologyStructural bioinfomatics Schlessinger Laboratory Focusing on the development and application of computational tools to annotate the functions of proteins Avner Schlessinger
Neurology Sealfon Laboratory Using diverse systems biology approaches to study and model the mechanisms of cellular decoding of extracellular stimuli Stuart C Sealfon
EpigeneticsEnvironmental ExposureExposomeChildren's health Senator Frank R. Lautenberg Environmental Health Sciences Laboratory Measures human environment comprehensively including chemicals, air pollution, social stressor and nutrition Jia ChenRobert O WrightManish AroraRosalind J Wright
Cognitive and behavioral neuroscience Shapiro Laboratory Examining the neural mechanisms of memory Matthew Shapiro
Microbiology Shaw Laboratory Antiviral Drug Discovery, Virus Activation and Inhibition of Host Innate Immune Pathways Megan L Shaw
Bioinformatics Shen Laboratory Performing statistical and integrated analysis of molecular mechanisms of drug addiction and depression Li Shen
CancerAutoimmunityDendritic cellsAntigen presentationAnti-tumor therapy Shu-Hsia Chen Laboratory Our goal is to combine activation of innate and adaptive immunity Shu-Hsia Chen
Cancer Sidi Laboratory Using genetic and chemical-genetic approaches in live zebrafish embryos and cultured human cancer cells to delineate novel targets for personalized cancer treatments Samuel Sidi
Genetics and genomicsOncologyTargeted therapiesBreast cancer Silva Laboratory Characterization of the breast cancer genome and identification of novel breast cancer targeted therapies through functional genomics. Jose M Silva
HIV Simon Laboratory Studying virus-host interactions using retroviruses including HIV, SIV, HTLV and human endogenous retroviruses (HERVS) Viviana A Simon
NeurologyOtolaryngologyPathophysiology Simonyan Laboratory Investigating pathophysiology of primary dystonia through neuroimaging, neuropathological, clinical, genetic, and environmental correlates Kristina Simonyan
VirologyClinical pathology Singh Laboratory Studying viral replication, especially of retroviruses such as HIV-1, Moloney murine leukemia virus, and XMRV Ila Singh
CancerLymphatic system Skobe Laboratory Members of the Skobe lab conduct groundbreaking molecular research linking the dynamic relationship between the lymphatic system and cancer metastasis Mihaela Skobe
Membrane excitability and diseaseNeurology Slesinger Laboratory A major focus of neuroscience research is to understand the function of neural circuits in both normal and diseased states Paul Slesinger
Cardiology Sobie Laboratory Increasing a fundamental understanding of how calcium signaling in heart cells interacts with and influences the heart's electrical and mechanical function Eric A Sobie
Developmental and regenerative biology Sokol Laboratory Exploring various processes in epithelial cells; stem cells; migrating cells; asymmetric division; growth factors; and mechanotransduction Sergei Y Sokol
Developmental and regenerative biology Soriano Laboratory Exploring the growth factor signaling pathways that have important roles in mouse embryonic development Philippe M Soriano
Spinal Cord Injury Laboratory Working to develop treatments for paraplegic and quadriplegic spinal cord injured patients Arthur L Jenkins III
Gene therapyDrug discoveryDiabetes Stewart Lab Translating human pancreatic beta cell biology into beta cell regeneration for diabetes therapy Andrew Stewart
Infectious diseases Swartz Laboratory Investigating signaling mechanisms that underlie chronic inflammation associated with HIV infection Talia H Swartz
Translational and biomedical informatics Tang Laboratory Research and development of novel imaging strategies for the study of neuropsychiatric diseases Cheuk Y Tang
Radiology Taouli Laboratory Optimizing and validating novel functional MRI techniques applied to diffuse and focal liver diseases, including diffusion-weighted MRI; dynamic contrast enhanced MRI; MR Elastography; flow quantification; spectroscopy; and multi echo Dixon methods Bachir Taouli
Cardiology Tarzami Laboratory Analyzing the role of chemokines on cardiac myocyte biology; focused on cardiac physiology in both in vitro and in vivo models of heart failure
VirologyMicrobiologySynthetic biology TenOever Laboratory Exploiting host biochemistry to control virus biology Benjamin R tenOever
AutoimmunityThyroid function Thyroid Laboratory Researching thyroid autoimmune disease, with a main focus on the TSH receptor Terry F Davies
Immunology Virology Tortorella Laboratory Investigating virus-host interactions and development of anti-viral therapeutics Domenico Tortorella
Transdisciplinary Center on Health Effects of Early Environmental Exposures Integrating methods in molecular biology, chemistry, biostatistics, bioinformatics and phenotyping to develop new methods to address how environment shapes health and disease Philip J LandriganRobert O Wright
Tissue bankingEpigeneticsEpilepsyNeurodevelopmentNeuro-Oncology Tsankova Laboratory The main goal of our lab is to obtain deeper understanding of the molecular drivers of proliferation and differentiation during normal neural development as well as in pathological conditions, such as gliomagenesis and reactive gliosis, in order to expose superior targets for drug therapy in gliomas and drug-resistant epilepsy. To do this, our lab uses variety of next generation molecular tools and functional assays in order to characterize distinct human cell populations acutely derived from fresh clinical samples. Nadejda Tsankova
Biochemistry Ubarretxena Laboratory Investigating the role of eukaryotic membrane proteins in cellular processes and in disease
Immunotherapy Vaccine and Cell Therapy Laboratory Translating promising laboratory results into novel therapies by providing a dedicated and controlled facility for the manufacturing of immunotherapies against cancer and infectious diseases Rachel L Sabado
Neurodegenerative diseaseSleep studiesMemory Varga Laboratory The Varga laboratory aims to understand the role of normal sleep and sleep disruption on memory formation and risk for neurodegenerative disease. Andrew W Varga
Liver cancer Villanueva Laboratory Development of a molecular classification of hepatocellular carcinoma (HCC), and an integrated model of HCC prognosis Augusto Villanueva Rodriguez
AgingDiabetes Vlassara Laboratory, Experimental Diabetes and Aging Conducting research in areas as diverse as atherosclerosis, kidney disease, and disorders of the central nervous system Helen Vlassara
Genomics Warburton Laboratory Researching epigenetics of human centromere formation and function; DNA sequence requirements; chromatin domain structure and histone modifications; and repetitive DNA structure of the human genome Peter E Warburton
Reproductive biochemistry Wassarman Laboratory Focusing on mammalian egg and sperm surface components that account for species-restricted binding during fertilization Paul M Wassarman
Lung cancer Watanabe Laboratory Studies transcriptional regulation of lung cancer through single cell and epigenomic technologies Hideo Watanabe
Gene therapy Weber Laboratory Focusing on on adeno-associated virus, a promising gene therapy vector Thomas Weber
Cellular and molecular neurobiology Weiss Laboratory Combining behavioral, morphological, electrophysiological, cell biological and molecular-biological techniques Klaudiusz R Weiss
Chronic Illness Self-ManagementHealth Outcomes among World Trade Center Rescue and Recovery WorkersLung cancer treatment and outcomes Wisnivesky Laboratory The Wisnivesky Laboratory focuses on chronic pulmonary disease management and cancer epidemiology and outcomes research. We have several federally-funded studies assessing the self-management, treatment, and outcomes for patients with asthma, COPD, multimorbidity, and lung cancer. Juan Wisnivesky
Induced pluripotent cellsCorneal and conjunctival stem cellsEpithelial stem cellsExfoliation syndromeOcular surface regeneration Wolosin Laboratory Primary focus on stem cells of the limbal-corneal epithelial lining regenerative approaches Jose M Wolosin
Gene therapy Woo Laboratory Investigating various processes and applications of gene therapy
Stem cellsTissue engineeringOphthalmologyOcular surface regenerationDevelopmental and regenerative biology Wu Laboratory Creating transplantable eye tissue by reprogramming adult and pluripotent stem cells into human corneal and conjunctival epithelial cells in order to treat corneal, oculoplastic and other blinding eye diseases. Albert Wu
Ocular HealthGenomic medicineGenetics and genomics Xu Laboratory Understanding how the network of transcription factors/chromatin regulators and gene interactions drive progenitor cell development, maintenance, and regeneration in the inner ear and kidney.
Tumor microenvironmentTherapeutic targeting of tumor microenvironment Yu Laboratory Exploring the effects of tumor microenvironment on tumor progression, tumor angiogenesis, and maintenance of cancer stem cells (CSCs) Qin Yu
Neurology Yue Laboratory Studying molecular and cellular mechanisms of neurodegeneration that cause human neurological disorders such as Parkinson’s, Huntington’s and Alzheimer’s diseases Zhenyu Yue
Cellular neuropharmacology Zachariou Laboratory Using advanced genetic mouse models, viral mediated gene transfer and optogenetics, to understand network and cell type mechanisms underlying chronic pain, addiction, and depression Venetia Zachariou
Modified RNACardiac regenerationGeneticsCardiology Zangi Laboratory Our labs research is centralized around the novel gene delivery system Modified RNA. Using this technology, we explore the genetic environment in a post-myocardial infarcted heart and discover modified RNA's potential for cardiac survival and regeneration invivo. Lior Zangi
Bioinformatics Zhang Laboratory Providing a bioinformatics infrastructure that integrates analysis of diverse data from genome and proteome level, to clinical investigations Weijia Zhang
ArrhythmiaMolecular cardiologyIntegrative genomicsDevelopmental and regenerative biology Zhao Laboratory The laboratory's main focus is transcriptional regulation in cardiac development and disease. Yong Zhao
Multiscale biology Genetics Zhu Laboratory Studying integrative network biology Jun Zhu
Neuronal regeneration Zou Laboratory of Axonal Growth and Neuronal Regeneration Researching molecular mechanisms of neuronal birth, extend axons, regeneration or failure to regenerate after mammalian CNS injury Hongyan Zou