Projects and Grants


Influenza viruses are virulent pathogens infecting up to 500 million people annually worldwide. Last century, influenza pandemics in 1918, 1957, and 1968 caused millions of deaths, with the most severe epidemic in 1918-1919 leading to an estimated 40 million fatalities. Although it is not possible to predict when the next pandemic might occur, that an influenza pandemic will occur is almost certain. With the recent emergence of highly pathogenic avian influenza (HPAI) strains, understanding the emergence, transmission, and pathogenesis of influenza viruses is vital for developing vaccines and therapeutics and protecting public health.


The Center for Research on Influenza Pathogenesis (CRIP) is dedicated to understanding influenza by conducting novel collaborative research into virus pathogenesis, host restriction, transmission, evolution and host adaptation, interactions between influenza virus proteins and gene segments, evasion of immunity, and induction of host responses. Through this research program, scientists at CRIP will promote better understanding of the host range of influenza viruses and the molecular and immunological factors leading to pandemic flu.

CRIP is a Center of Excellence in Influenza Research and Surveillance (CEIRS) funded by the National Institute for Allergy and Infectious Diseases (NIAID).