Affiliated Faculty, Members of IPM
Yvonne Yu-Feng Chan, MD FACEP
Assistant Professor, Department of Emergency Medicine
KL2 Clinical and Translational Research PhD Candidate Scholar
Member, The Charles Bronfman Institute for Personalized Medicine
Dr. Chan is a board-certified Emergency Medicine physician with experience in stroke clinical trials, patient education, and pharmacogenomics. Her formal research training includes two years of NIH/NINDS T32 post-doctoral cerebrovascular research fellowship as well as Mount Sinai Graduate School of Biological Sciences’ PhD in Clinical research (anticipated receipt of her doctoral degree in June, 2013).
Dr. Chan is the Principal Investigator of the NIH/Clinical and Translational Science Award-funded KL2 grant ‘Pharmacogenomics of clopidogrel in the Mount Sinai Biobank stroke patients’. She is also a co-investigator of two NINDS-funded trials: the ‘Platelet-Oriented Inhibition in New TIA and minor ischemic stroke (POINT) Trial’ as well as the DESERVE trial. In addition, Dr. Chan is currently collaborating with the Institute of Personalized Medicine faculty on the CLIPMERGE (CLinical Implementation of Personalized Medicine through Electronic Health Records and Genomics) project.
Research Interests:
- Stroke/clopidogrel pharmacogenomics
- Stroke genomics
- Personalized medicine
- Stroke clinical trials
Joel Dudley, PhD
Assistant Professor of Genetics and Genomic Sciences
Director of Biomedical Informatics
Institute for Genomics and Multiscale Biology
Member, The Charles Bronfman Institute for Personalized Medicine
Joel Dudley is a veteran bioinformatics scientist focused on developing and applying integrative informatics methodologies to enable and accelerate translational science. His current research is focused towards solving key problems in genomic and systems medicine, with recent publications in the areas of clinical genomics, pharmacogenomics, drug repurposing, and biomarker discovery. Joel's recent work with co-authors (published in Science Translational Medicine) describing a novel systems based approach for computational drug repositioning was featured in the print edition of the Wall Street Journal, and earned designation as the NHGRI Director's Genome Advance of the Month. His current research at Mount Sinai is focused towards multiscale integration of diverse clinical and molecular data for applications in precision medicine and therapeutic discovery. He is co-author of the forthcoming book "Exploring Personal Genomics" from Oxford University Press.
Research Interests:
- Translational bioinformatics
- Genomic and systems medicine
- Personalized and precision medicine
- Clinical genomics
- Multiscale data integration
Carol Horowitz, MD
Associate Professor, Health Evidence and Policy, Medicine
Associate Professor, Department of Health Evidence and Policy and Department for Medicine
Co-Director, Center for Health Equity and Community-Engaged Research
Member, The Charles Bronfman Institute for Personalized Medicine
Dr. Horowitz is a general internist and health services researcher, who conducts community-engaged research to address health disparities and impact chronic disease prevention and control.
She works with the Institute on projects related to health disparities and community engagement.
She leads the community engagement and diversity activities for the NHGRI-funded U01 grant ‘Biorepositories for Genomic Medicine in Diverse Communities’, and is a member of the CERC workgroup of NHGRI’s ‘Electronic Medical Records and Genomics’ (eMERGE) II Network. She is also PI of NIH and CDC-funded grants and centers on diabetes, obesity and stroke prevention.
Research Interests:
- Health Disparities and Health Equity research
- Community-Based Participatory Research
- Chronic Disease Prevention and Control
- Community Based Interventions
Jean-Sebastien Hulot, MD, PhD
Assistant Professor, Medicine
Director of Pharmacogenomics and Personalized Therapeutics at the Cardiovascular Research Center
Member, The Charles Bronfman Institute for Personalized Medicine
Dr. Hulot is a medical cardiologist with a PhD in clinical and experimental pharmacology. He has an extensive background in clinical and basic research in cardiovascular pharmacology. He is interested in developing genome-guided therapies for cardiovascular diseases.
Dr. Hulot serves as the Director of Pharnacogenomics and Personalized Therapeutics at the Cardiovascular Research Center. He is one of the co-investigator of IPM’s innovative EMR-linked Biobank Program.
Dr. Hulot is a co-Investigator of the NHGRI-funded U01 grant ‘Biorepositories for Genomic Medicine in Diverse Communities’. He has been involved in the conception and development of different clinical trials aiming to develop personalized medicine in cardiology (CLOVIS-2 NCT 00822666; GIANT trial NCT01134380; ARCTIC-Gene NCT 00827411). His laboratory is an affiliate member of the PharmacoGenetics Research Network. Dr Hulot has participated to the Clinical Pharmacogenetics Implementation Consortium (CPIC) working on clopidogrel pharmacogenetics and is a member of the steering committee of NIH International Clopidogrel Pharmacogenetics Consortium (ICPC).
Dr. Hulot is also an NIH-funded investigator leading laboratory research on gene therapy in heart failure.
Research Interests:
- genetic basis of responses to cardiovascular drugs
- human induced pluripotent stem cells in cardiovascular diseases
- gene and genome-guided therapies in cardiovascular disease
Inga Peter, PhD
Associate Professor, Department of Genetics and Genomic Sciences
Member, The Charles Bronfman Institute for Personalized Medicine
Dr. Peter is a Genetic Epidemiologist in the Department of Genetics and Genomic Sciences. She has extensive experience in designing studies aimed to identify genetic risk factors associated with complex diseases, such as type 2 diabetes, obesity, cardiovascular disease and Crohn’s disease, as well as with response to therapeutic and lifestyle interventions.
She serves as the Principal and co-Investigator on a number of projects that involve Mount Sinai BioMe Biobank participants.
Dr. Peter is the co-Investigator of the NHGRI-funded U01 grant ‘Biorepositories for Genomic Medicine in Diverse Communities’ (eMERGE) and IPM-funded grant ‘Evaluating Information Needs to Generate Community Engagement and Genomics Education’ (ENGAGE). She also leads two pilot studies focused on the Mount Sinai BioMe Biobank population: 1) to determine genetic variants associated with type 2 diabetes in the absence of obesity and 2) to identify differences in microbial content between obese and lean diabetics. In addition, she is the Principal Investigator of the NHLBI-funded R01 grant aimed to identify genetic factors associated with response to metabolic therapy in a setting of acute coronary syndrome. Furthermore, Dr. Peter is leading laboratory research on mechanisms of Crohn’s disease.
Research Interests:
- Genetics of complex diseases through next generation sequencing
- Pharmacogenetics and genetic risk modification by means of lifestyle intervention
- MicroBioMe studies of Crohn’s disease, type 2 diabetes, and obesity
- Population genetics of Ashkenazi Jews
Shaun Purcell, PhD
Professor, Psychiatry, Genetics and Genomic Sciences
Director, Center for Statistical Genetics
Associate Professor of Psychiatry
Associate Professor of Genetics & Genomic Sciences
Member, The Charles Bronfman Institute for Personalized Medicine
Dr. Purcell is a genetic epidemiologist whose work focuses on developing statistical and computational tools for the design of genetic studies, the detection of gene variants influencing complex human traits and the dissection of these effects in the larger context of other genetic and environmental factors. In particular, Dr. Purcell currently works on whole exome resequencing and whole genome association studies of bipolar disorder and schizophrenia and the development of tools for whole genome and exome genetic studies. He directs the Center for Statistical Genetics at Icahn School of Medicine, and is a Member of the Division of Psychiatric Genomics and the Institute for Genomics and Multiscale Biology.
Dr. Purcell collaborates on a number of genetic studies ongoing in the IPM.
Dr. Purcell is Principal Investigator on NIH-funded grants for whole-exome sequencing in schizophrenia and bipolar disorder, and for developing analytic tools for next-generation sequencing studies, in addition to being an Investigator on several other large-scale, collaborative genetic studies of neuropsychiatric disease. He is the Chair of Mount Sinai’s Genomics arm of the eMERGE II project.
Research Interests:
- Development of statistical genetic methodology and computational tools for large-scale genotyping and sequencing studies
- Neuropsychiatric genetics
- Characterizing the genetic architecture of common disease
Lynne Richardson, MD
Professor, Emergency Medicine
Professor of Emergency Medicine
Professor of Health Evidence and Policy
Vice Chair for Academic, Research and Community Programs
Department of Emergency Medicine
Member, The Charles Bronfman Institute for Personalized Medicine
Dr. Lynne D. Richardson is Professor of Emergency Medicine, Professor of Health Evidence & Policy, and Vice Chair for Academic, Research and Community Programs of the Department of Emergency Medicine at the Icahn School of Medicine in New York City. A native New Yorker, she holds Bachelor’s degrees from the Massachusetts Institute of Technology (MIT) in Life Sciences and Management; and an MD degree from the Albert Einstein College of Medicine. Dr. Richardson is a nationally recognized health services researcher.
Dr. Richardson is one of the Principal Investigators for Projects ENGAGE and ENGAGE II (Engaging Neighborhoods in General and Personalized Genomics Education). Project ENGAGE was funded by IPM in 2009 to explore community attitudes about genomics and personalized medicine, and to identify informational needs and preferences of community members. Dr. Richardson is leading the community engagement aim of Project ENGAGE and is currently completing Spanish language focus groups and interviews to inform the development of informational modules in English and Spanish.
For the past eight years, Dr. Richardson has been the Principal Investigator for "Community VOICES", an NIH-funded study which is seeking to develop effective methods for communicating with communities about emergency research. She is also Co-Director of the CEREDI program – an NIH funded initiative to use comparative effectiveness research to eliminate health disparities. She was recently awarded one of the nation’s first Emergency Medicine Research Career Development Program (K12), an institutional training grant to develop emergency medicine investigators. For the past eight years she has served on the New York City Board of Health and was recently appointed to the Advisory Committee to the Director of the Centers for Disease Control.
Research Interests:
- Access and barriers to care
- Emergency department crowding
- Healthcare disparities
Saskia C. Sanderson, PhD
Assistant Professor, Department of Genetics and Genomic Sciences
Member, The Charles Bronfman Institute for Personalized Medicine
Dr. Sanderson is a health psychology research scientist with a particular interest in the intersection between genomics, communication and behavior. Her research focuses on the cognitive, emotional and behavioral impact of providing patients with personal genomic information. She also works on the upstream communication of complex genomic information and assisting patients make informed decisions about receiving personal genomic results.
Dr. Sanderson is one of the Principal Investigators of the IPM Project ENGAGE (Engaging Neighborhoods in General and Personalized Genomics Education). She is also Co-Investigator on the NHGRI-funded U01 grant ‘Biorepositories for Genomic Medicine in Diverse Communities’, and a member of the CERC (Consent, Education, Regulation and Consultation) workgroup of NHGRI’s ‘Electronic Medical Records and Genomics’ (eMERGE) II Network.
Research Interests:
- Public understanding, attitudes and interest in receiving personal genomic information
- Communication of complex genomic information
- Development of genomics education for healthcare providers, patients and public
- Informed decision-making about personal genomic information
- Cognitive, emotional and behavioral impact of personal genomic information
- Application of health psychology theory in the genomics context
Stuart Scott, PhD
Assistant Professor, Department of Genetics and Genomic Sciences
Assistant Director, Mount Sinai Genetic Testing Laboratory
Member, The Charles Bronfman Institute for Personalized Medicine
Dr. Scott is a clinical laboratorian, who is certified by the American Board of Medical Genetics (ABMG) in both clinical molecular genetics and clinical cytogenetics. In addition to genetics and genomics, his research interests currently include pharmacogenetics and epigenetics, as well as clinical implementation of genetic testing and personalized medicine.
Dr. Scott serves as a Co-Investigator of IPM’s eMERGE program by providing expertise in clinical genetics and implementing pharmacogenetic testing.
Dr. Scott is a KL2 Faculty Scholar at the Icahn School of Medicine with ongoing research projects in collaboration with Mount Sinai cardiologists on cardiovascular pharmacogenetics. An additional research focus is the identification of novel alleles, including copy number variants, involved in interindividual drug response variability by studying ethnically diverse populations. Dr. Scott is also a Co-Investigator of the NHLBI-sponsored Clarification of Optimal Anticoagulation Through Genetics (COAG) warfarin pharmacogenetics clinical trial as Mount Sinai is one of 12 clinical sites throughout the United States.
Research Interests:
- Clinical molecular genetics
- Clinical cytogenetics and cytogenomics
- Pharmacogenetics and pharmacogenomics
- Epigenetics and epigenomics
Weijia Zhang, PhD
Associate Professor of Medicine
Director, Bioinformatics Laboratory
Member, The Charles Bronfman Institute for Personalized Medicine
Dr. Zhang is a bioinformatician and native of China. He has been trained in both cell biology and computer science and has extensive experience in genomic analysis. His current research focuses on development and implementation of bioinformatics tools/pipeline in high throughput genomic analysis of research and clinical specimen.
He serves as the Bioinformatics Director and is the key person in genomic data analysis of EMR-linked specimens in BioMe Biobank of Institute of Personalized Medicine.
Dr. Zhang is a Co-investigator of the NHGRI-funded U01 grant ‘Biorepositories for Genomic Medicine in Diverse Communities’, and is responsible for SNP and sequencing data analysis for projects of NHGRI’s ‘Electronic Medical Records and Genomics’ (eMERGE) II Network at the Icahn School of Medicine. He is also a subcontract site-PI of several NIH funded projects including ' The Pathogenesis of HIV-Associated Nephropathy', ' Targeting Renal Inflammatory Pathways of SLE Nephritis in Mouse and Man' and ' DIaT as a transcriptional regulator of non-replicating Mycobacterium tuberculosis'.
Research Interests:
- integrative analysis of candidate SNPs from genome-wide association analysis study of human complex diseases
- algorithm and pipeline development of deep-sequencing analysis
- genomics aberration study in cancer and hematological malignancies