Projects and Grants

Grant Title: Hydrodynamic forces modulate renal tubular function
Funding Agency: Veterans Affairs Central Office

Hypertension is a prevalent medical disorder affecting >30% of the adult U.S. population over the age of 40. It increases a person’s risk for kidney disease, stroke, coronary artery disease, congestive heart failure and overall mortality. Reducing blood pressure to normal levels decreases the morbidity and mortality associated with hypertension, but does not bring morbidity and mortality back to control levels. The etiology behind the development of hypertension is unknown, but investigators have demonstrated that abnormal renal prostaglandin metabolism, which affects Na homeostasis, can lead to Na retention and hypertension.

In this research application, we identify a novel physiologic mechanism by which prostaglandin synthesis may be regulated by the kidney, and consequently, renal Na homeostasis. By elucidating the mechanisms by which urine flow rate, and its hydrodynamic forces, can activate prostaglandin synthesis in the kidney, we will identify mechanisms which regulate renal Na homeostasis as well as target genes and proteins to prevent the development of hypertension.

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Rajeev Rohatgi, MD
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