Selected Publications

Tissue Engineering and Cardiac Repair

Lee EJ, Holmes JW, Costa KD. Remodeling of engineered tissues in response to altered boundary conditions. Ann Biomed Eng, 26:1322-1334, 2008.

Lee EJ, Kim DE, Azeloglu EU, Costa KD. Engineered cardiac organoid chambers: toward a functional biological model ventricle. Tissue Eng Part A, 14:215-225, 2008.

Cheng RK, Asai T, Tang H, Dashoush NH, Kara RJ, Costa KD, Naka Y, Wu EX, Wolgemuth DJ, Chaudhry HW. Cyclin A2 induces cardiac regeneration after myocardial infarction and prevents heart failure. Circ Res, 100:1741-1748, 2007. (cover article)

Costa KD, Lee EJ, Holmes JW. Creating alignment and anisotropy in engineered heart tissue: the role of boundary conditions in a model three-dimensional culture system. Tissue Eng, 9:567-577, 2003. (cover article)


Atomic Force Microscopy and Cell Mechanobiology

Cheung YK, Azeloglu EU, Shiovitz DA, Costa KD, Seliktar D, Sia SK. Microscale control of stiffness in cell-adhesive substrate using microfluidics-based lithography. Angew Chem, (in press).

Azeloglu EU, Bhattacharya J, Costa KD. Atomic force microscope elastography reveals phenotypic differences in alveolar cell stiffness. J Appl Physiol, 105:652-661, 2008.

Elkin BS, Azeloglu EU, Costa KD, Morrison B 3rd. Mechanical heterogeneity of the rat hippocampus measured by atomic force microscope indentation. J Neurotrauma, 24:812-822, 2007.

Kuncicky DM, Bose K, Costa KD, Velev OD. Sessile droplet templating of miniature porous hemispheres from colloid crystals. Chem Mater, 19:141-143, 2007.

Costa KD. Imaging and probing cell mechanical properties with the atomic force microscope. Methods Mol Biol, 319:331-361, 2006.

Costa KD, Sim, AJ, Yin FCP. Non-Hertzian approach to analyzing mechanical properties of endothelial cells probed by atomic force microscopy. J Biomech Eng, 128:176-184, 2006.


Cardiovascular Biomechanics

Duan Q, Angelini ED, Herz SL, Ingrassia CM, Costa KD, Holmes JW, Homma S, Laine AF. Optical flow based endocardium tracking on real-time three-dimensional ultrasound. Ultrasound Med Biol, 35:256-265, 2009.

Azeloglu EU, Albro M, Thimmappa V, Ateshian GA, Costa KD. Heterogeneous proteoglycan distribution provides a mechanism for regulating residual stresses in the aorta. AJP Heart Circ Physiol, 294:H1197-H1205, 2008.

Lee W-N, Ingrassia CM, Fung-Kee-Fung SD, Costa KD, Holmes JW, Konofagou EE. A theoretical framework for quality assessment in myocardial elastography. IEEE Trans Ultrason Ferroelectr Freq Control, 54:2233-2245, 2007.

Ingrassia CM, Usyk TP, Kerckhoffs RCP, McCulloch AD, Costa KD, Holmes JW. Model-based development of four-dimensional wall motion measures. Comput Methods Appl Mech Engrg, 196:3061-3069, 2007.