Selected Publications

Rangamani P, Xiong GY, Iyengar R. Multiscale modeling of cell shape from the actin cytoskeleton. Prog Mol Biol Transl Sci. 2014;123:143-67.

Azeloglu EU, Hardy SV, Eungdamrong NJ, Chen Y, Jayaraman G, Chuang PY, Fang W, Xiong H, Neves SR, Jain MR, Li H, Ma'ayan A, Gordon RE, He JC, Iyengar R. Interconnected network motifs control podocyte morphology and kidney function. Sci Signal. 2014 Feb 4;7(311):ra12.

Zhao S, Nishimura T, Chen Y, Azeloglu EU, Gottesman O, Giannarelli C, Zafar MU, Benard L, Badimon JJ, Hajjar RJ, Goldfarb J, Iyengar R. Systems pharmacology of adverse event mitigation by drug combinations. Sci Transl Med. 2013 Oct 9;5(206):206ra140. Abstract | Reprint | Full Text | Supplementary Materials

Rangamani P, Lipshtat A, Azeloglu EU, Calizo RC, Hu M, Ghassemi S, Hone J, Scarlata S, Neves SR, Iyengar R. Decoding information in cell shape. Cell. 2013 Sep 12;154(6):1356-69.

Hansen J, Iyengar R. Computation as the mechanistic bridge between precision medicine and systems therapeutics. Clin Pharmacol Ther. 2013 Jan;93(1):117-28.

Boran AD, Seco J, Jayaraman V, Jayaraman G, Zhao S, Reddy S, Chen Y, Iyengar R. A potential Peptide therapeutic derived from the juxtamembrane domain of the epidermal growth factor receptor. PLoS One. 2012;7(11):e49702.

Iyengar R, Zhao S, Chung SW, Mager DE, Gallo JM. Merging systems biology with pharmacodynamics. Sci Transl Med. 2012 Mar 21;4(126):126ps7. Full Text (PDF) | Full Text (HTML)

Hwangpo TA, Jordan D, Premsrirut PK, Jayamaran G, Licht J, Iyengar R, Neves SR. GRIN modulates Sprouty repression of MAPK activation by growth factor stimulation. J Biol Chem. 2012 Apr 20;287(17):13674-85.

Zhao S, Iyengar R. Systems pharmacology: network analysis to identify multiscale mechanisms of drug action. Annu Rev Pharmacol Toxicol. 2012 Feb 10;52:505-21.

Hansen J, Zhao S, Iyengar R. Systems pharmacology of complex diseases. Ann N Y Acad Sci. 2011 Dec;1245:E1-5.

Mazloom AR, Dannenfelser R, Clark NR, Grigoryan AV, Linder KM, Cardozo TJ, Bond JC, Boran ADW, Iyengar R, Malovannaya A, Lanz RB, Ma'ayan A. Recovering Protein-Protein and Domain-Domain Interactions from Aggregation of IP-MS Proteomics of Coregulator Complexes. PLoS Comput Biol. 2011 Dec;7(12): e1002319.

He JC, Chuang PY, Ma'ayan A, Iyengar R. Systems biology of kidney diseases. Kidney Int. 2012 Jan;81(1):22-39.

Boran AD, Chen Y, Iyengar R. Identification of new Gβγ interaction sites in adenylyl cyclase 2 Cell Signal. 2011 Sep;23(9):1489-95.

Rangamani P, Fardin MA, Xiong Y, Lipshtat A, Rossier O, Sheetz MP, Iyengar R. Signaling network triggers and membrane physical properties control the actin cytoskeleton-driven isotropic phase of cell spreading. Biophys J. 2011 Feb 16;100(4):845-57.

Michailidis IE, Rusinova R, Georgakopoulos A, Chen Y, Iyengar R, Robakis NK, Logothetis DE, Baki L. Phosphatidylinositol-4,5-bisphosphate regulates epidermal growth factor receptor activation. Pflugers Arch. 2011 Mar;461(3):387-97.

Berger SI, Iyengar R. Role of systems pharmacology in understanding drug adverse events. Wiley Interdiscip Rev Syst Biol Med. 2011 Mar;3(2):129-35.

Fardin MA, Rossier OM, Rangamani P, Avigan PD, Gauthier NC, Vonnegut W, Mathur A, Hone J, Iyengar R and Sheetz MP. Cell spreading as a hydrodynamic process. Soft Matter, 2010, 6, 4788-4799.

Boran AD, Iyengar R. Systems pharmacology. Mt Sinai J Med. 2010 Jul;77(4):333-44.

Iyengar R. Drug discovery in academic settings. Mt Sinai J Med. 2010 Jul-Aug;77(4):325-6.

Xiong Y, Rangamani P, Fardin MA, Lipshtat A, Dubin-Thaler B, Rossier O, Sheetz MP, Iyengar R. Mechanisms controlling cell size and shape during isotropic cell spreading. Biophys J. 2010 May 19;98(10):2136-46.

Boran AD, Iyengar R. Systems approaches to polypharmacology and drug discovery. Curr Opin Drug Discov Devel. 2010 May;13(3)297-309.

Berger SI, Ma'ayan A, Iyengar R. Systems pharmacology of arrhythmias. Sci Signal. 2010 Apr 20;3(118):ra30. Abstract | Full Text (PDF) | Full Text (HTML)

Lipshtat A, Jayaraman G, He JC, Iyengar R. Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues. Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1247-52.

Zorina Y, Iyengar R, Bromberg KD. Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth. J Biol Chem. 2010 Jan 8;285(2):1358-70.

Berger SI, Iyengar R. Network analyses in systems pharmacology. Bioinformatics. 2009 Oct 1;25(19):2466-72.

Abul-Husn NS, Bushlin I, Morón JA, Jenkins SL, Dolios G, Wang R, Iyengar R, Ma'ayan A, Devi LA. Systems approach to explore components and interactions in the presynapse. Proteomics. 2009 Jun;9(12):3303-15.

Lipshtat A, Neves SR, Iyengar R. Specification of spatial relationships in directed graphs of cell signaling networks. Ann N Y Acad Sci. 2009 Mar;1158:44-56.

Wist AD, Berger SI, Iyengar R. Systems pharmacology and genome medicine: a future perspective. Genome Med. 2009 Jan 22;1(1):11.

Ma'ayan A, Jenkins SL, Barash A, Iyengar R. Neuro2A Differentiation by G{alpha}i/o Pathway. Sci Signal. 2009 Jan 20;2(54):cm1.

Ma'ayan A, Jenkins SL, Webb RL, Berger SI, Purushothaman SP, Abul-Husn NS, Posner JM, Flores T, Iyengar R. SNAVI: Desktop application for analysis and visualization of large-scale signaling networks. BMC Syst Biol. 2009 Jan 20;3(1):10.

Rangamani P, Iyengar R. Modelling cellular signalling systems. Essays Biochem. 2008;45:83-94.

Sarkar A, Wist A, Iyengar R. Signaling networks in biology. In Wiley Encyclopedia of Chemical Biology. John Wiley & Sons, Inc. 2008.

Ma'ayan A, Lipshtat A, Iyengar R, Sontag ED. Proximity of intracellular regulatory networks to monotone systems. IET Syst Biol. 2008 May;2(3):103.

Bromberg KD, Iyengar R, He JC. Regulation of neurite outgrowth by Gi/o signaling pathways. Front Biosci. 2008 May 1;13:4544-57.

Bromberg KD, Ma'ayan A, Neves SR, Iyengar R. Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science. 2008 May 16;320(5878):903-9.
Abstract | Full Text (PDF) | Full Text (HTML) 

Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R. Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks. Cell. 2008 May 16;133(4):666-80.

Iyengar R, Diverse-Pierluissi MA, Jenkins SL, Chan AM, Devi LA, Sobie EA, Ting AT, Weinstein DC. Inquiry learning. Integrating content detail and critical reasoning by peer review. Science. 2008 Feb 29;319(5867):1189-90.

Lipshtat A, Purushothaman SP, Iyengar R, Ma'ayan A. Functions of bifans in context of multiple regulatory motifs in signaling networks. Biophys J. 2008 Apr 1;94(7):2566-79.

Berger SI, Iyengar R, Ma'ayan A. AVIS: AJAX Viewer of Interactive Signaling Networks. Bioinformatics. 2007 Oct 15;23(20):2803-5.

Zaidel-Bar R, Itzkovitz S, Ma'ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat Cell Biol. 2007 Aug;9(8):858-67.

Ma'ayan A, Jenkins SL, Goldfarb J, Iyengar R. Network analysis of FDA approved drugs and their targets. Mt Sinai J Med. 2007 May 21;74(1):27-32.

Rangamani P, Iyengar R. Modelling spatio-temporal interactions within the cell. J Biosci. 2007 Jan;32(1):157-67.

Eungdamrong NJ, Iyengar R. Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi. Biophys J. 2007 Feb 1;92(3):808-15.

Ma'ayan A, Iyengar R. From components to regulatory motifs in signalling networks. Briefings in Functional Genomics and Proteomics. 2006 Mar;5(1):57-61.

Ma'ayan A, Lipshtat A, Iyengar R. Topology of resultant networks shaped by evolutionary pressure. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jun;73(6 Pt 1):061912.

Ma'ayan A, Gardiner K, Iyengar R. The cognitive phenotype of Down syndrome: insights from intracellular network analysis. NeuroRx. 2006 Jul;3(3):396-406.

He JC, Neves SR, Jordan JD, Iyengar R. Role of the Go/i signaling network in the regulation of neurite outgrowth. Can J Physiol Pharmacol. 2006 Jul;84(7):687-694.

Ma'ayan A, Blitzer RD, Iyengar R. Toward predictive models of mammalian cells. Annu Rev Biophys Biomol Struct. 2005;34:319-49.

Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R. Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science. 2005 Aug 12;309(5737):1078-83.
Abstract | Full Text (PDF) | Full Text (HTML)

He JC, Gomes I, Nguyen T, Jayaram G, Ram PT, Devi LA, Iyengar R. The Galpha o/i coupled cannabinoid receptor mediated neurite outgrowth involves Rap regulation of Src and Stat3. J Biol Chem. 2005 Sep 30;280(39):33426-34.

Jordan JD, He JC, Eungdamrong NJ, Gomes I, Ali W, Nguyen T, Bivona TG, Philips MR, Devi LA, Iyengar R. Cannabinoid receptor induced neurite outgrowth is mediated by Rap1 activation through Galphao/I-triggered proteasomal degradation of Rap1GAPII. J Biol Chem 2005 Mar 25; 280(12):11413-11421.

Campagne F, Neves S, Chang CW, Skrabanek L, Ram PT, Iyengar R, Weinstein H. Quantitative information management for the biochemical computation of cellular networks. Sci STKE. 2004 Aug;(248):pl11.

Eungdamrong NJ, Iyengar R. Modeling cell signaling networks. Biol Cell. 2004 Jun;96(5):355-62.

Yoo B, Iyengar R, Chen Y. Functional analysis of the interface regions involved in interactions between the central cytoplasmic loop and C-terminal tails of adenylyl cyclase. J Biol Chem. 2004 Apr 2;279(14):13925-33.

Buck E, Iyengar R. Organization and functions of interacting domains for signaling by protein-protein interactions. Sci STKE. 2003 Nov 18;2003(209):re14.

Neves SR, Iyengar R. Modeling of signaling networks. Bioessays. 2002 Dec;24(12):1110-7.

Buck E, Schatz P, Scarlata S, Iyengar R. Role of dynamic interactions in effective signal transfer for Gbeta stimulation of phospholipase C-beta 2. J Biol Chem. 2002 Dec 20;277(51):49707-15.

Li G, Iyengar R. Calpain as an effector of the Gq signaling pathway for inhibition of Wnt/beta -catenin-regulated cell proliferation. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13254-9.

Obrink B, Sawa H, Scheffrahn I, Singer BB, Sigmundsson K, Sundberg U, Heymann R, Beauchemin N, Weng G, Ram P, Iyengar R. Computational analysis of isoform-specific signal regulation by CEACAM1-A cell adhesion molecule expressed in PC12 cells. Ann N Y Acad Sci. 2002 Oct;971:597-607.

Bhalla US, Ram PT, Iyengar R. MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science. 2002 Aug 9;297(5583):1018-23.

Neves SR, Ram PT, Iyengar R. G protein pathways. Science. 2002 May 31;296(5573):1636-9.

Santore TA, Chen Y, Smit MJ, Iyengar R. Adenovirus-directed expression of Q227L-G alpha(s) inhibits growth of established tumors of later-stage human breast cancer cells in athymic mice. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1671-6.

Chen Y, Yoo B, Lee JB, Weng G, Iyengar R. The signal transfer regions of G alpha(s). J Biol Chem. 2001 Dec 7;276(49):45751-4.

Buck E, Iyengar R. Modular design of Gbeta as the basis for reversible specificity in effector stimulation. J Biol Chem. 2001 Sep 21;276(38):36014-9.

Ram PT, Iyengar R. G protein coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation. Oncogene. 2001 Mar 26;20(13):1601-6.

Bhalla US, Iyengar R. Robustness of the bistable behavior of a biological signaling feedback loop. Chaos. 2001 Mar;11(1):221-226.

Holness W, Santore TA, Brown GP, Fallon JT, Taubman MB, Iyengar R. Expression of Q227L-Galpha(s) inhibits intimal vessel wall hyperplasia after balloon injury. Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1288-93.

Jordan JD, Landau EM, Iyengar R. Signaling networks: the origins of cellular multitasking. Cell. 2000 Oct 13;103(2):193-200.

Ram P, Iyengar R. Stat3-mediated transformation of NIH-3T3 cells by the constitutively active Q205L Galphao protein. Science. 2000 Jan 7;287(5450):142-4.

Contact Us

Ravi Iyengar, PhD
Dorothy H. and Lewis Rosenstiel Professor, Department of Pharmacology and Systems Therapeutics
Director, Systems Biology Center New York (SBCNY)
Tel: 212-659-1707
Fax: 212-831-0114
Send email

Icahn Medical Institute
Room 12-70C (Office)
12-52 (Lab)
Pharmacology and Systems Therapeutics
1425 Madison Avenue
New York NY 10029