The Li Laboratory (Li Lab) at the Cardiovascular Research Center at Mount Sinai Medical Center is an electrophysiology laboratory. Our mission is to develop cell- and gene-based approaches for heart regeneration. We are particularly interested in the associated electrophysiological consequences (arrhythmias), at the single- and multi-cellular (tissue/organ) levels.
Our investigators study the biology of ion channel proteins, hESC/iPSC, cardiac differentiation, specification and maturation, then apply the basic knowledge gained to develop tools and applications for drug discovery, cardiotoxicity screening, and potential therapies via a range of protein and cell engineering approaches.
The Li Lab's work in these areas has been recognized by the American Heart Association as Best Basic Study of 2005, Ground-Breaking Study of 2006, and Late-Breaking Studies of 2003, 2004 and 2007. Specific ongoing topics include bio-artificial pacemaker (as an alternative or supplement to conventional electronic devices), heart cell engineering, construction of 2-D and 3-D human heart tissues, cardiac microRNA, etc.
Dr. Ronald Li is Senior Faculty in Cardiology and co-Director, with Dr. Kevin Costa, of the Section of Cardiovascular Cell and Tissue Engineering at the Cardiovascular Research Center of Mount Sinai Medical School of Medicine. Dr. Li also concurrently runs the stem cell program at Hong Kong University. He earned his B.S. (Hons) in Biochemistry/Biotechnology and his PhD in Cardiology/Physiology from the University of Waterloo and University of Toronto in Canada in 1994 and 1999, respectively. Subsequently, he joined the Johns Hopkins University (JHU) School of Medicine to undertake a post-doctoral fellowship in Cardiac Electrophysiology.
In 2002, he was promoted to Assistant Professor of Medicine at JHU. In light of California's Proposition 71 for stem cell research, he was recruited in 2005 to the University of California, Davis as a tenured Associate Professor with cross appointments in Biomedical Engineering, Biophysics, Genetics, Physiology and Cell Biology, and an Associate Investigator of the Institute of Pediatric Regenerative Medicine at the Shriners Hospital for Children. During that time, he was also an Adjunct Associate Professor of Medicine at HKU. At UC Davis, he led the Human Embryonic Stem Cell Consortium. Dr Li has over 80 publications in the areas.
The Li Laboratory receives funding from the National Institute of Health, California Institute of Regenerative Medicine, American Heart Association, Research Grant Council, etc. Dr Li has served as a panel member or reviewer for a number of funding agencies, including the National Institutes of Health, American Heart Association, Association Francaise contre les Myopathies, United States-Israel Binational Science Foundation, Research Grant Council of Hong Kong, Stem Cell Consortium, A*STAR/Biopolis of Singapore, Wellcome Trust and MRC of the United Kingdom, etc.