Research Overview

The research group is interested in studying the structure and function of G protein-coupled receptors (GPCRs), their interacting proteins, and neuropsychiatric disease associations. GPCRs share a characteristic topology consisting of seven alpha-helical transmembrane spans, and owe their name to their signal transduction via heterotrimeric G proteins. The utility of this structural template is evident from its wide evolutionary conservation. GPCRs are the target of more than half of currently approved therapeutic agents. Ongoing research projects employ the coordination of several interdisciplinary approaches ranging from computer modeling, molecular and cellular techniques to behavioral experiments in mouse models and epigenetic assays in postmortem human brain samples. Our final goal is understand the molecular mechanisms through which GPCRs affect the biological state of individual neurons, as well as to elucidate how this is translated into behavioral outputs, with the ultimate goal of discovering new approaches for the treatment and prevention of neuropsychiatric disorders such as schizophrenia, major depression, and suicidal behavior.

Contact Us

Javier González-Maeso, PhD
Tel: 212-824-8973
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One Gustave L. Levy Place
Box 1229
New York, NY 10029