Sealfon Laboratory Research

The Sealfon Laboratory, in the Center for Translational Systems Biology and Department of Neurology, uses diverse systems biology approaches to study and model the mechanisms of cellular decoding of extracellular stimuli.

We are particularly interested in understanding the molecular network mechanisms underlying signal decoding, the role of noise in cell signaling and the mechanisms for processing multiple extracellular inputs. The overall goal of our work is to understand how a cell recognizes and generates an appropriate response to different but closely related extracellular signals or stimuli. We apply diverse experimental and computational approaches towards characterizing the single cell response in complex tissues. We work in several experimental systems in order to try to identify common schemes of cellular data processing.