Recognition and Publications

Dhandapany PS, Fabris F, Tonk R, Illaste A, Karakikes I, Sorourian M, Sheng J, Hajjar RJ, Tartaglia M, Sobie EA, Lebeche D, Gelb BD. Cyclosporine attenuates cardiomyocyte hypertrophy induced by RAF1 mutants in Noonan and LEOPARD syndromes. J Mol Cell Cardiol. 2011 Apr 7.

Lee YS, Dun W, Boyden PA, Sobie EA. Complex and rate-dependent beat-to-beat variations in Ca(2 ) transients of canine Purkinje cells. J Mol Cell Cardiol. 2011 Apr;50(4):662-9.

Macquaide N, Ramay HR, Sobie EA, Smith GL. Differential sensitivity of Ca2 wave and Ca2 spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes. J Physiol. 2010 Dec 1;588(Pt 23):4731-42.

Hartman JM, Sobie EA, Smith GD. Spontaneous calcium sparks and calcium homeostasis in a minimal model of permeabilized ventricular myocytes. Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1996-2008.

Chung CY, Bien H, Sobie EA, Dasari V, McKinnon D, Rosati B, Entcheva E. Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization. FASEB J. 2010 Nov 17.

Sarkar AX, Sobie EA. Regression analysis for constraining free parameters in electrophysiological models of cardiac cells. PLoS Comput Biol. 2010 Sep 2;6(9):e1000914.

Williams GS, Smith GD, Sobie EA, Jafri MS. Models of cardiac excitation-contraction coupling in ventricular myocytes. Math Biosci. 2010 Jul;226(1):1-15.

Ramay HR, Jafri MS, Lederer WJ, Sobie EA. Predicting local SR Ca2+ dynamics during Ca2+ wave propagation in ventricular myocytes. Biophys J. 2010 Jun 2;98(11):2515-23.

Josephson IR, Guia A, Sobie EA, Lederer WJ, Lakatta EG, Stern MD. Physiologic gating properties of unitary cardiac L-type Ca2+ channels. Biochem Biophys Res Commun. 2010 May 10.

Trafford AW, Lederer WJ, Sobie EA. Keeping the beat: life without SERCA--is it possible? J Mol Cell Cardiol. 2009 Aug;47(2):171-3.

Sobie EA, Ramay HR. Excitation-contraction coupling gain in ventricular myocytes: insights from a parsimonious model. J Physiol. 2009 Mar 15;587(Pt 6):1293-9.

Sobie EA. Parameter sensitivity analysis in electrophysiological models using multivariable regression. Biophys J. 2009 Feb 18;96(4):1264-74.

Bridge JH, Torres NS, Sobie EA. New insights into the structure and function of couplons. J Physiol. 2008 Aug 15;586(16):3735.

Williams GS, Huertas MA, Sobie EA, Jafri MS, Smith GC. Moment closure for local control models of calcium-induced calcium release in cardiac myocytes. Biophys J. 2008 Aug;95(4):1689-703.

Wang LJ, Sobie EA. Mathematical model of the neonatal mouse ventricular action potential. Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2565-75.

Iyengar R, Diverse-Pierluissi MA, Jenkins SL, Chan AM, Devi LA, Sobie EA, Ting AT, Weinstein DC. Inquiry learning. Integrating content detail and critical reasoning by peer review. Science. 2008 Feb 29;319(5867):1189-90.

Sobie EA, Cannell MB, Bridge JH. Allosteric activation of Na+-Ca2+ exchange by L-type Ca2+ current augments the trigger flux for SR Ca2+ release in ventricular myocytes. Biophys J. 2008 Apr 1;94(7):L54-6.

Sobie EA, Kao JP, Lederer WJ. Novel approach to real-time flash photolysis and confocal Ca2+ imaging. Pflugers Arch: European Journal of Physiology 2007 Jul;454(4):663-73.

Ni J, Auston DA, Freilich DA, Muralidharan S, Sobie EA, Kao JP. Photochemical gating of intracellular Ca2+ release channels. J Am Chem Soc. 2007 May 2;129(17):5316-7.

Williams GS, Huertas MA, Sobie EA, Jafri MS, Smith GD. A probability density approach to modeling local control of calcium-induced calcium release in cardiac myocytes. Biophys J. 2007 Apr 1;92(7):2311-28.

Collis LP, Meyers MB, Zhang J, Phoon CK, Sobie EA, Coetzee WA, Fishman GI. Expression of a sorcin missense mutation in the heart modulates excitation-contraction coupling. FASEB J. 2007 Feb;21(2):475-87.

Sobie EA, Song LS, Lederer WJ. Restitution of Ca2+ release and vulnerability to arrhythmias. J Cardiovasc Electrophysiol. 2006; 17 Suppl 1: S64-S70.

Sobie EA, Guatimosim S, Gomez-Viquez L, Song LS, Hartmann H, Saleet JM, et al. The Ca2+ leak paradox and rogue ryanodine receptors: SR Ca2+ efflux theory and practice. Prog Biophys Mol Biol. 2006; 90: 172-185.

Song LS, Sobie EA, McCulle S, Lederer WJ, Balke CW, Cheng H. Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci U S A. 2006; 103: 4305-4310.

Knot HJ, Laher I, Sobie EA, Guatimosim S, Gomez-Viquez L, Hartmann H, et al. Twenty years of calcium imaging: cell physiology to dye for. Mol Interv. 2005; 5: 112-127.

Sobie EA, Song LS, Lederer WJ. Local recovery of Ca2+ release in rat ventricular myocytes. J Physiol. 2005; 565: 441-447.

Song LS, Guatimosim S, Gomez-Viquez L, Sobie EA, Ziman A, Hartmann H, et al. Calcium biology of the transverse tubules in heart. Ann N Y Acad Sci. 2005; 1047: 99-111.

Lederer WJ, Guatimosim S, Song LS, Sobie EA, Hartmann H, Lukyanenko V. Ca2+ sparks in heart muscle. J Muscle Res Cell Motil. 2004; 25: 602-603.

Sobie EA, Jafri MS, Lederer WJ. Computer models of cardiac Ca2+ release and Ca2+ sparks. Lecture Notes in Physics. 2003; 623: 97-114.

Sobie EA, Guatimosim S, Song LS, Lederer WJ. The challenge of molecular medicine: complexity versus Occam's razor. J Clin Invest. 2003; 111: 801-803.

Zhang H, Noble D, Cannell M, Orchard CH, Lancaster M, Jones SA, et al. Dynamics of cardiac intracellular Ca2+ handling - From experiments to virtual cells. International Journal of Bifurcation and Chaos. 2003; 13: 3535-3560.

Guatimosim S, Dilly K, Santana LF, Jafri MS, Sobie EA, Lederer WJ. Local Ca2+ signaling and EC coupling in heart: Ca2+ sparks and the regulation of the [Ca2+]i transient. J Mol Cell Cardiol. 2002; 34: 941-950.

Sobie EA, Dilly KW, Dos Santos CJ, Lederer WJ, Jafri MS. Termination of cardiac Ca2+ sparks: an investigative mathematical model of calcium-induced calcium release. Biophys J. 2002; 83: 59-78.

Guatimosim S, Sobie EA, Dos Santos CJ, Martin LA, Lederer WJ. Molecular identification of a TTX-sensitive Ca(2+) current. Am J Physiol Cell Physiol. 2001; 280: C1327-C1339.

Cheng DK, Tung L, Sobie EA. Nonuniform responses of transmembrane potential during electric field stimulation of single cardiac cells. Am J Physiol. 1999; 277: H351-H362.

Susil RC, Sobie EA, Tung L. Separation between virtual sources modifies the response of cardiac tissue to field stimulation. J Cardiovasc Electrophysiol. 1999; 10: 715-727.

Riemer TL, Sobie EA, Tung L. Stretch-induced changes in arrhythmogenesis and excitability in experimentally based heart cell models. Am J Physiol. 1998; 275: 431-42.

Sobie EA, Tung L. Postshock potential gradients and dispersion of repolarization in cells stimulated with monophasic and biphasic waveforms. J Cardiovasc Electrophysiol. 1998; 9: 743-756.

Sobie EA, Susil RC, Tung L. A generalized activating function for predicting virtual electrodes in cardiac tissue. Biophys J. 1997; 73: 1410-1423.

Fishler MG, Sobie EA, Tung L, Thakor NV. Modeling the interaction between propagating cardiac waves and monophasic and biphasic field stimuli - the importance of the induced spatial excitatory response. J Cardiovasc Electrophysiol. 1996; 7: 1183-1196.

Fishler MG, Sobie EA, Thakor NV, Tung L. Mechanisms of cardiac cell excitation with premature monophasic and biphasic field stimuli - a model study. Biophys J. 1996; 70: 1347-1362.

Fishler MG, Sobie EA, Tung L, Thakor NV. Cardiac responses to premature monophasic and biphasic field stimuli: results from cell and tissue modeling studies. J Electrocardiol. 1995; 28: 174-179.

Contact Us

Eric A. Sobie, PhD
Tel: 212-659-1706
Fax: 212-831-0114

Icahn Medical Institute
12th Floor, Room 12-70F (Office)
1425 Madison Avenue
New York NY 10029