Research Overview

Our laboratory investigates the role of eukaryotic membrane proteins in cellular processes and in disease. Membrane proteins constitute over 30% of all proteins encoded in a cell genome and are the target of more than half of the therapeutic drugs currently used in medicine. We use high-resolution electron cryomicroscopy, X-ray crystallography and solution NMR to determine the structure of membrane proteins and we then integrate the structural information with mechanistic and functional studies. The long-term aim is to learn how to modulate membrane protein function to open new avenues for therapeutic strategies.