Our laboratory studies the role of Wnt signaling in the genesis of colon cancer and has two main areas of focus:
1. Activity of resveratrol for colon cancer prevention
we have found that a natural compound found in the skin of grapes, resveratrol, inhibits the Wnt signaling pathway and may be of use in the prevention of colon cancer. Research in this area includes basic laboratory investigations into the mechanism of Wnt pathway inhibition as well as translational trials in patients receiving dietary or supplement interventions. An exciting area of focus is the development of novel synthetic resveratrol-like compounds that are preferentially targeted to and activated in cancer cells.
2. Wnt signaling in the colon tumor microenvironment
Despite the presence of activating mutations in the majority of sporadic colon cancers, modulation of Wnt signaling related to Wnt ligand secretion or alteration of other cell surface signaling components can be critical in determining the strength of the Wnt signal. Our laboratory is investigating how changes in the tumor microenvironment induced by or affecting Wnt signaling relate to the development and progression of colon cancer.
Tel: 212-241-2191 (Lab) 212-659-5412 (Office)
Annenberg Building, Room 24-16
One Gustave L. Levy Place
New York, NY 10029