Works In Progress
The Department of Pharmacological Sciences hosts a biweekly Works in Progress Discussion Series where trainees discuss their research ideas, design, results, and receive feedback in an informal setting. Two WiP presentations are held per session. This series is held on Thursdays at 11 am in a virtual format via Zoom. For presenting at the WiP Series, please contact DPS@mssm.edu.
|
Date |
Details |
|---|---|
|
December 14 |
“Epigenetic Alterations in Pulmonary Endothelial Cells” “Applications of WNTinib in Colorectal Cancer and Hepatocellular Carcinoma Models” |
|
November 30 |
Structural and Biochemical Studies of the Novel Endoribonuclease YicC” |
|
November 16 |
“Targeting Enzymatic Activities of the Bacterium Burkholderia Cenocepacia” “Design and Synthesis of BRD4/BRD2-ET Domain Targeting Inhibitors” |
|
November 2 |
“PRMT5 regulates Global and ZNF326 Symmetrical Demethylation of Arginine “Camelid Nanobodies against Staphylococcus Aureus Antigens” |
|
October 26 |
PRMT5 regulates Global and ZNF326 Symmetrical Demethylation of Arginine “Prediction of Small Molecule Ligands for SLC4A10 by AlphaFold2 Modeling and Virtual Screening” |
|
October 5 |
“Molecular Features of Trace Amine-associated Receptor 1 Activation” “Predicting the Functional Impacts of Pathogenic Genetic Variants with Machine Learning” |
|
September 7 |
“NAD Regulation by Novel Small Molecules” |
|
August 24 |
|
|
August 10 |
“Unveiling the Bone Remodeling Symphony: The Skeletal Impact of CGMP-Dependent Protein Kinase G (PKG) Type 2” |
|
July 27 |
"Screening Genetic Targets of Alzheimer's Disease in CRISPRa/i Microglia” |
|
July 13 |
“Prevention of Diet Induced Obesity by FSH Blockade: Dose-Finding Studies” |
|
June 29 |
“Understanding Activation Mechanism of Mu-Opioid Receptors Coupled to G Proteins” |
|
June 6 |
“Design of Small Molecules for the Treatments of Neurological Disorders and Cancer Diseases” |
|
June 1 |
“Development of Monoclonal Antibody (MS-Hu6) Formulation, Biophysical Characterization and Stability Evaluation”
|
|
April 20 |
“Multi-drug Combination Effects on Physical Therapy-enabled Recovery After SCI” |
|
April 6 |
“Design of Small Molecules for the Treatments of Neurological Disorders and Cancer Diseases” |
|
March 23 |
“AI-Guided Computational Tools for Nanobody Discovery and Bioengineering” |
|
March 9 |
“Automated Model Parameterization for Studying Electrophysiological Variation in hiPSC-derived Cardiomyocytes” |
|
February 23 |
“Structural Studies of a Renal Organic Cation Transporter” |
|
February 9 |
“Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Cyclin D” |
|
January 26 |
“Super-immunity by Pan-sarbecovirus Nanobodies” |
|
2022 |
|
|
Date |
Details |
|
December 15 |
“Design & Synthesis of BRD4/BRD2-ET Domain Targeting Compounds” |
|
December 8 |
“Angiotensin Receptors and Vascular Disease” |
|
December 1 |
“Structural Pharmacology of Psychedelic Tryptamines” |
|
November 10 |
“Investigating Dynamics Modulating of SLC Transporter LAT1 Function” |
|
October 13 |
“Structural and Functional Evidence of Novel Antidepressant Action at Understudied Serotonin Receptors” |
|
September 29 |
“Predicting Gain and Loss of Function Variants with Machine Learning” “Discovery of Novel Histone Lysine Methyltransferase PROTAC Degraders” |
|
September 15 |
“Using Confirmation Sensitive Protein KInase C Antibody to Probe G Protein Coupled Receptor Signaling” |
|
September 1 |
“Ultrastructure of the Sarcoplasmic Reticulum and Ca2+ Release Cluster Modulate Local Ca2+ Release” |
|
August 4 |
“Develop the Novel Sequencing Technique CUT&Tag for Epigenomic Profiling of FOXI1 Utilizing Cystic Fibrosis as a Disease Model” “Early Dissemination of Breast Cancer Cells” |
|
June 23 |
“Drug Discovery and Cardiotoxicity Models: hiPSC-Derived Cardiac Models’ Maturity Boosted by 3D Culturing Affecting Drugs Toxicity Predictions” |
|
June 2 |
“Unveiling and Exploiting the Structural Determinants of HCN2 Channel Selectivity” “SigCom LINCS: Gene Expression Signature Portal for Drug and Target Discovery” |
|
May 12 |
“Singular Value Decomposition Based Identification of Drug Specific Transcriptomic Signatures in Healthy Human Subject iPSC Derived Cardiomyocytes” |
|
March 31 |
“lncHUB2: Predicted Biological Functions and Drug/Disease Associations for lncRNAs” |
|
March 3 |
“Targeting Triple Negative Breast Cancer with VHL-recruiting EZH2 Protein Degrader” |
|
February 17 |
“Stabilizers and Destabilizers of the Protein-Protein Interaction” |
|
January 20 |
“Welcome Address” |
|
2021 |
|
|
Date |
Details |
|
December 16 |
“Structural Signatures: Using Patterns of Structures in Expressed Proteins to Understand Underlying Biological Phenomena” |
|
November 18 |
“Rational Design of Small Molecules Targeting LAT1” |
|
October 21 |
“Synthesis and pharmacology of a novel μ-δ opioid receptor heteromer selective agonist based on the carfentanyl template” “The Regulation of Pancreatic Cancer Cell Death Through Autophagy Inhibition” |
|
September 23 |
“Structural and Biochemical Studies of a Pseudokinase ULK4” “Pharmacological Characterization of Understudied Aminergic Receptors” |
|
September 9 |
“Discovery of First-in-class eEF1A2 Degraders for Pancreatic Cancer” |
|
August 26 |
“First-in-Class Humanized FSH Blocking Antibody Targets Bone and Fat” |
|
July 1 |
“Mechanisms of Resistance and Sensitivity to TNBCs” |
|
June 3 |
“Early Dissemination of Tumor Cells in Breast Cancer” |
|
May 20 |
“Discovery and characterization of a fifth 3' exonuclease in Bacillus subtilis” “Applying Single Cell RNA-Sequencing to Map the Cystic Fibrosis Airway and Chart the Cell Type-Specific Regulation and Expression of CFTR” |
|
May 6 |
“Interaction of BRD2/BRD4 and E-protein of SARS-CoV2 Stimulates Cytokine Storm” “A Perfluoroalkane Toolkit for Type II Kinase Inhibitors and Rational Polypharmacology” |
|
April 22 |
‘Insights into kidney physiology from the Kidney Precision Medicine Project” |
|
March 25 |
‘Making the LINCS L1000 Data Look Like RNA-seq with Deep Learning” |
|
March 11 |
‘Predicting Targets for 17 Types of Pain with Machine Learning” |
|
February 25 |
“Structural Basis for the Action of Anticancer Drug Trametinib” |
|
January 21 |
“Conversations with the Chair” |