Latest News
At the Extremes, Human Traits May Have Different Genetic Basis
May 27, 2026 – Researchers have found evidence that people who fall at the extreme high or low ends of certain traits, such as cholesterol, blood glucose, height, and age at menopause, are more likely to have a simple genetic explanation than previously thought. Their findings may lead to new insights into the causes of common diseases.
Study Reveals “Bet-Hedging” Strategy That Helps Gut Bacteria Survive and Recover
May 19, 2026 – Researchers have discovered that many gut bacteria use a flexible survival strategy to withstand disruptions such as antibiotics and diet changes. The study shows microbes can switch between functional states, rather than relying solely on genetic mutations, to try to survive shifting conditions. The findings shed light on a previously hidden layer of microbiome biology and may help explain why probiotics and fecal microbiota transplantation (FMT) produce inconsistent benefits across individuals.
Scientists Identify Dysregulation of RNA Editing as Contributor to Altered Fetal Brain Development in Down Syndrome
March 31, 2026 – A collaborative research study has for the first time identified a biological process that may help explain how the brain develops differently in people with Down syndrome. The findings revolve around a gene that produces an enzyme called ADARB1 (also known as ADAR2), a molecule that helps edit genetic messages inside cells.
New Research Reveals Autism Risk Genes Are Shared Across Ancestries
March 30, 2026 - A new study demonstrates that genes associated with autism risk are largely the same across people of different ancestries. The findings, based on one of the largest genomic studies of Latin American individuals to date, provide strong evidence that the genetic architecture of autism is consistent across diverse populations. They underscore the importance of expanding genetic research beyond individuals of European ancestry.
Researchers Identify the Most Common Recessive Neurodevelopmental Disorder Ever Discovered
March 30, 2026 - Researchers have identified and described a previously unknown recessive neurodevelopmental disorder (NDD) that appears to be the most prevalent ever discovered. The condition is caused by changes in a small noncoding gene called RNU2-2. It is estimated to affect thousands of individuals in the United States and account for about 10 percent of all recessive NDD cases with a known genetic cause.
Mount Sinai Scientists Recognized With Global AI Prize for Novel Alzheimer’s Disease Research Platform
March 27, 2026 - A team led by Dr. Kuan-lin Huang, PhD, has been named a winner of the $1 million Alzheimer’s Insights AI Prize. The award honors the development of Biomni-AD, an advanced AI-powered “co-scientist” designed to dramatically reduce the time required to generate scientific insights from complex biomedical data.
Largest Genetic Study of Schizophrenia and African Ancestry Reveals Shared Biology Across Global Populations
January 21, 2026 - A team of researchers led by scientists from the Icahn School of Medicine at Mount Sinai and collaborators has conducted the largest and most comprehensive genome-wide association study (GWAS) to date of schizophrenia in individuals of African ancestry. The landmark study identifies more than 100 previously unrecognized schizophrenia risk regions and highlights the importance of inclusive genetic research.
New AI Tool Identifies Not Just Genetic Mutations, But the Diseases They May Cause
December 15, 2025 - Scientists at the Icahn School of Medicine at Mount Sinai have developed a novel artificial intelligence tool that not only identifies disease-causing genetic mutations but also predicts the type of disease those mutations may trigger.
Protective Microglia Subtype Offers Potential New Therapeutic Pathway in Alzheimer’s Disease
November 05, 2025 - In Alzheimer’s disease, the leading cause of dementia, microglia—the brain’s immune defenders—can act as both protectors and aggressors, shaping how the disease progresses. Researchers from the Icahn School of Medicine at Mount Sinai and collaborators have identified a distinct population of neuroprotective microglia that may point to a new therapeutic approach for Alzheimer’s disease.
Scientists Develop a Way to Track Donor Bacteria After Fecal Microbiota Transplants
October 22, 2025 - Researchers at the Icahn School of Medicine at Mount Sinai and their collaborators have developed a new technology to track beneficial bacteria after fecal microbiota transplants (FMT). The approach provides a detailed view of how donor microbes take hold and persist in the patients’ gut—not only which bacteria successfully colonized but how they change over time. These insights may guide the design of safer and more effective microbiome-based therapies.
New Software Tool Aims to Help Scientists Better Analyze Complex Spatial Data From Tissues
October 1, 2025 - Researchers at the Icahn School of Medicine at Mount Sinai in New York, Boston Medical Center, and Boston University Chobanian & Avedisian School of Medicine, have developed a software platform to help scientists more easily analyze the molecular structure of tissue in both healthy and disease states.
New Protein Interaction Map Sheds Light on How Brain Cell Communication Breaks Down in Alzheimer’s Disease
September 25, 2025 - A new study led by the Icahn School of Medicine at Mount Sinai offers one of the most comprehensive views yet of how brain cells interact in Alzheimer’s disease, mapping protein networks that reveal communication failures and point to new therapeutic opportunities.
Mount Sinai Researchers Use AI and Lab Tests to Predict Genetic Disease Risk
August 28, 2025 - When genetic testing reveals a rare DNA mutation, doctors and patients are frequently left in the dark about what it actually means. Now, researchers at the Icahn School of Medicine at Mount Sinai have developed a powerful new way to determine whether a patient with a mutation is likely to actually develop disease, a concept known in genetics as penetrance.
Study Reveals How Inherited Genes Help Shape the Course of Cancer
April 14, 2025 - A new multicenter study by researchers at the Icahn School of Medicine at Mount Sinai, in collaboration with the National Cancer Institute-funded Clinical Proteomic Tumor Analysis Consortium (CPTAC) and colleagues around the world, has discovered that the genes we are born with—known as germline genetic variants—play a powerful, underappreciated role in how cancer develops and behaves.
Landmark Study Identifies New Genetic Cause of Neurodevelopmental Disorders, Bringing Long-Awaited Answers to Families
April 10, 2025 - A seminal study from researchers at the Icahn School of Medicine at Mount Sinai and their collaborators in the United Kingdom, Belgium, Spain, the Netherlands, and Iceland has uncovered a new genetic cause of neurodevelopmental disorders (NDDs).
Mount Sinai Researchers Develop Novel Computational Approach for Identifying Synergistic Drug Combinations
February 20, 2025 - Researchers at the Icahn School of Medicine at Mount Sinai have developed a powerful computational tool, named iDOMO, to improve the prediction of drug synergy and accelerate the development of combination therapies for complex diseases.
New Study Identifies Genetic Changes in Brain Development That May Contribute to Schizophrenia
October 10, 2024 - A collaborative study between researchers at the Icahn School of Medicine at Mount Sinai and Harvard Medical School has identified genetic mutations that occur during brain development and may contribute to the development of schizophrenia.
Mount Sinai researchers introduce web portal empowering drug discovery and systems-level analysis of critical kinase-substrate interactions
October 3, 2024 - Researchers from the Icahn School of Medicine at Mount Sinai have introduced KiNet, an interactive web portal designed to explore kinase-substrate interactions in human cellular systems.
New Insights Into Intellectual Disability Genetics Emerge at Mount Sinai
September 23, 2024 - Researchers at the Icahn School of Medicine at Mount Sinai have published a pivotal study in Nature Genetics that sheds light on a novel genetic variant associated with intellectual capacities and educational outcomes.
New Four-Year, $3.26 Million Grant From the National Institute of Neurological Disorders and Stroke Establishes the Mount Sinai Center for Undiagnosed Diseases
September 19, 2024 - A new four-year, $3.26 million grant from the National Institute of Neurological Disorders and Stroke (NINDS), a part of the National Institutes of Health (NIH), establishes the first Undiagnosed Diseases Network (UDN) site in the New York metropolitan area.
Mount Sinai Researchers Unveil Comprehensive Youth Diabetes Dataset and Interactive Portal to Boost Research and Prevention Strategies
July 02, 2024 - A team from the Icahn School of Medicine at Mount Sinai has developed the most comprehensive epidemiological dataset for youth diabetes and prediabetes research, derived from extensive National Health and Nutrition Examination Survey (NHANES) data collected from 1999 to 2018.
New AI Tool Finds Rare Variants Linked to Heart Disease in 17 Genes
June 11, 2024 - Using an advanced artificial intelligence tool, researchers at the Icahn School of Medicine at Mount Sinai have identified rare coding variants in 17 genes that shed light on the molecular basis of coronary artery disease (CAD), the leading cause of morbidity and mortality worldwide.
Researchers Identify a Genetic Cause of Intellectual Disability Affecting Tens of Thousands
May 31, 2024 - Researchers at the Icahn School of Medicine at Mount Sinai and others have identified a neurodevelopmental disorder, caused by mutations in a single gene, that affects tens of thousands of people worldwide.
Altering Cellular Interactions Around Amyloid Plaques May Offer Novel Alzheimer’s Treatment Strategies
May 27, 2024 - Researchers at the Icahn School of Medicine at Mount Sinai have made a significant breakthrough in Alzheimer’s disease research by identifying a novel way to potentially slow down or even halt disease progression.
Mount Sinai study identifies genetic link between inflammatory bowel disease and Parkinson’s disease
May 13, 2024 - Researchers at the Icahn School of Medicine at Mount Sinai have made a significant discovery, identifying genetic connections between inflammatory bowel disease (IBD) and Parkinson’s disease (PD).
Immune Cells Identified as Key Players in Brain Health
March 21, 2024 - Using novel genetic and genomic tools, researchers at the Icahn School of Medicine at Mount Sinai have shed light on the role of immune cells called macrophages in lipid-rich tissues like the brain, advancing our understanding of Alzheimer’s and other diseases.
AI Finds Key Signs That Predict Patient Survival Across Dementia Types
February 28, 2024 - Researchers at the Icahn School of Medicine at Mount Sinai and others have harnessed the power of machine learning to identify key predictors of mortality in dementia patients.
Researchers Characterize the Immune Landscape in Cancer
February 14, 2024 - Researchers from the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium of the National Institutes of Health, The University of Texas MD Anderson Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and others, have unveiled a detailed understanding of immune responses in cancer, marking a significant development in the field.
Icahn School of Medicine at Mount Sinai Receives Helmsley Charitable Trust Grant for Crohn's Disease Research
January 25, 2024 - The Icahn School of Medicine at Mount Sinai has been awarded a grant of more than $4 million from The Leona M. and Harry B. Helmsley Charitable Trust to support an innovative research project aimed at understanding the early stages of Crohn’s disease before noticeable symptoms develop.
Genomic ‘tweezer’ ushers in a new era of precision in microbiome research
January 4, 2024 - In a landmark study recently published in the journal Nature Methods, researchers at the Icahn School of Medicine at Mount Sinai have unveiled mEnrich-seq—an innovative method designed to substantially enhance the specificity and efficiency of research into microbiomes, the complex communities of microorganisms that inhabit the human body.
Novel Genetic Priority Score Unveiled to Enhance Target Prioritization in Drug Development
January 3, 2024 - Driven by the need for a better way to prioritize targets for drug development, the Icahn School of Medicine at Mount Sinai has led the development of a novel “genetic priority score” (GPS) that will integrate various types of human genetic data into a single easy-to-interpret score.
Mount Sinai researchers develop novel method to improve disease prediction across diverse ancestries
December 20, 2024 - A team of scientists from Icahn School of Medicine at Mount Sinai has developed a groundbreaking statistical technique, “BridgePRS,” to enhance disease prediction in people of non-European ancestry, particularly those of African descent.
Unlocking the Human Genome: Innovative Machine Learning Tool Predicts Functional Consequences of Genetic Variants
December 14, 2023 - In a novel study, researchers from the Icahn School of Medicine at Mount Sinai introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain- and loss-of-function variants across the genome.
Mount Sinai Researchers Find More Than 4,700 Gene Clusters Crucial for Prognosis in 32 Cancer Types
November 13, 2023 - Researchers at the Mount Sinai Center for Transformative Disease Modeling have released a groundbreaking study identifying 4,749 key gene clusters, termed “prognostic modules,” that significantly influence the progression of 32 different types of cancer.
Mount Sinai Launches Discovery and Innovation Center in Midtown West
October 5, 2023 - The Mount Sinai Discovery and Innovation Center core facilities, located at 787 11th Avenue, will include a Stem Cell Engineering Core, the Center for Advanced Genomics Technology, Assay Development and Screening, the Center for Therapeutic Antibody Development, the Proteomics and Metabolomics Core, the Microscopy and Advanced Bioimaging Core, and a Flow Cytometry Core.
Unveiling Asthma's Molecular Secrets: How Blood Molecules Influence Airway Processes
September 20, 2023 - A new study by researchers at the Icahn School of Medicine at Mount Sinai has unraveled the intricate molecular interplay between systemic processes within the blood and localized processes within the airways of individuals with asthma.
Mount Sinai Researchers Uncover Early Signs in Gut Bacteria That Could Predict Peanut Allergy Development
August 28, 2023 - A new study led by researchers at the Icahn School of Medicine at Mount Sinai has revealed key differences in gut bacteria and their metabolic byproducts in infants that may predict the development of peanut allergies by mid-childhood.
Ovarian Cancer: New Biological Markers Found That May Predict Which Patients Won't Respond to Chemotherapy
August 3, 2023 - Using a novel proteogenomic strategy and a variety of machine learning tools, investigators from the Icahn School of Medicine at Mount Sinai and colleagues have identified a 64-protein signature that may predict a subset of ovarian cancer patients who are unlikely to respond to chemotherapy.
Mount Sinai Alzheimer’s Researcher Is the First Woman to Win Prize From Prestigious German Research Institute
July 12, 2023 - Alison M. Goate, DPhil, the Jean C. and James W. Crystal Professor and Chair of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, has been selected as the first female recipient of the Hartwig Piepenbrock-DZNE Prize for her outstanding contributions to research into Alzheimer’s disease and frontotemporal dementia.