Clinical Trials and Other Research Experiences

The Divisions of Pediatric Allergy and Immunology and Clinical Immunology conduct a number of clinical studies in adult allergy and asthma, pediatric and adult food allergy, and primary immunodeficiency.

Current ongoing clinical trials include:

  • Inner-city asthma consortium protocol ICAC-23: T-cell epitope characterization in cockroach allergy
  • Airway cellular and cytokine profiles in older patients with asthma
  • Role of estrogen in bradykinin production and degradation:
    • Studying the treatment of hyper-eosinophilic syndromes using anti-IL5 monoclonal antibodies
    • Investigating the use of Chinese herbal medicines for the treatment of allergic asthma and food allergies
    • Studying the use of immunotherapy to treat milk egg and peanut allergy
    • Investigating of the mechanism of outgrowing allergy, in particular, tolerance to heated milk and egg
    • Investigating genetic causes of antibody deficiencies
  • Building a Registry of Patients with Primary Immune Deficiency (USIDNET)
  • Studying Blocks to memory B cells in CVID
  • Examining IgA in mucosal Immunity
  • Identifying unknown Immune Defects by Whole Exome Sequencing:
    • Developing computer targeting methods to identify immunodeficiencies in minorities
    • Studying the use of immunomodulators in immune dysregulation diseases

As part of their fellowship training, fellows are encouraged to participate in one or more of these clinical trials. Some projects are also performed in the Clinical Research Unit, a facility sponsoring outpatient clinical research. Through involvement in these projects, fellows can gain practical skills and valuable experience in conducting clinical research protocols.

Teaching Experiences

Throughout the year, fellows play an active teaching role for medical students and residents who rotate through the adult and pediatric services. In addition, senior fellows organize talks for a series of introductory clinical lectures given to the first year fellows. Other formal teaching opportunities exist though presentations at the weekly Allergy and Immunology Grand Rounds, various journal clubs, and the preparation of resident teaching conferences for the house staff at the Mount Sinai Hospital and our affiliate community hospitals.

Electives

Fellows may also elect to spend time on the Rheumatology, Dermatology, Pulmonary, and/or Otolaryngology, services (among others) for additional experience in these areas. There is also the opportunity for further practice in interpreting lung function tests in the pulmonary function laboratory at Mount Sinai. Another popular elective is to rotate through the medical offices of our voluntary faculty throughout New York City to gain exposure to outpatient management in the private office environment.