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The Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai (PrIISM) is a new entity that encompasses and integrates disease-focused immunological research programs and cutting-edge technology centers. PrIISM is working to better understand the fundamental mechanisms used by immune cells to promote disease progression and response to treatment, developing and implementing novel technologies to better diagnose and guide treatment of disease, and generating new therapies to modulate the immune system in a broad spectrum of diseases, including cancer, inflammatory, cardiovascular, and neurological diseases.