Experimental Therapeutics Institute

eti spotlightETI is a hub for the development of drugs, devices, and intellectual property that result from Mount Sinai's basic and clinical research programs. Read More

The Mount Sinai Department of Pharmacology and Systems Therapeutics

Mount Sinai’s Dorothy H. and Lewis Rosenstiel Department of Pharmacology and Systems Therapeutics pursues a multifaceted mission of research, research training at the predoctoral and postdoctoral levels, and medical school teaching. Predoctoral training in pharmacological sciences is conducted under the auspices of the Mount Sinai Graduate School of Biomedical Sciences.

The disciplines of Pharmacology and Systems Therapeutics are devoted to the study of biological processes at molecular, cellular, tissue, and organismal levels in order to understand the mechanisms by which these processes function and how these processes can be modulated for therapeutic purposes. Studies often involve analysis of interactions of exogenous and endogenous substances with biological systems and the development of new therapeutics based on our understanding of cellular and molecular interactions. 

Biochemistry seeks to define life processes in terms of chemical interactions and reactions. Physiology defines how biochemical processes lead to tissue, organ, and organismal functions. Pharmacologists aim to understand how perturbation of these systems can lead to therapeutic modalities and how an organism's handling of specific therapeutic agents determines treatment regimens and affects therapeutic utility. Systems pharmacology and therapeutics represents a continuum of thought and research in understanding the origins and mechanisms underlying complex diseases and how they can be treated.

Our concentrations

Research activities in the department fall within three broad areas:

  • Biochemistry and Regulatory Biology
  • Applied Mathematics and Systems Biology
  • Physiology and Drug Development

The department is home to a National Institute of General Medical Sciences (NIGMS) National Center for Systems Biology. The center brings together faculty from the department and other departments at Mount Sinai with faculty at sister institutions in the New York area to develop the field of systems pharmacology. More information about the Systems Biology Center New York (SBCNY) and its activities can be found at www.sbcny.org.

Our facilities

The Department of Pharmacology and Systems Therapeutics is located on the 12th floor of Mount Sinai's Icahn Medical Institute (1425 Madison Avenue) and the 19th floor of the Annenberg Building (1468 Madison Avenue), where primary faculty have their laboratories and offices. There is easy access to other buildings in the medical center, including those housing the library, the preclinical teaching facilities, and the Hospital.


Contact Us

Icahn School of Medicine at Mount Sinai, Department of Pharmacology and Systems Therapeutics
One Gustave L. Levy Place, Box 1215
New York, NY 10029

Systems Biology of Disease and Therapeutics

systems bio brochureThe Graduate School of Biomedical Sciences offers a PhD in Biomedical Sciences in several training areas, including Systems Biology of Disease and Therapeutics. Read More