The Mount Sinai Department of
Structural and Chemical Biology

The Mount Sinai Department of Structural and Chemical Biology is dedicated to addressing the most challenging problems in human biology and disease at the fundamental molecular level by using experimental and computational structural biology, biophysics, and chemical biology methods. Scientists in the department study three-dimensional atomic structure, molecular function, and the regulation of biological macromolecules and complexes. They design novel chemical molecules to dissect molecular mechanisms underlying complex biological systems, and develop new therapeutic treatment for human diseases. Topics of investigation include:

  • Structure and function of cell membrane-bound proteins and receptors
  • Mechanisms of gene transcription and translation
  • Epigenetic and DNA damage repair in stem cells and immunity

Our goal is to understand the molecular basis of human diseases such as cancer, Alzheimer's disease, and genetic disorders. State-of-the-art research, shared resources in structural and chemical biology, and regular seminars and conferences support our research and academic training.

Our mission is to:

  • Provide a nurturing environment for discovery and innovation in basic and translational biomedical research of human biology and disease
  • Advance the academic training of physicians and scientists
  • Function as a scientific hub for interdisciplinary researcher that tackles the most challenging problems in biomedical sciences

Our faculty conduce a major portion of the multidisciplinary training in Structural/Chemical Biology and Molecular Design (SMD). SMD is one of the nine training areas that make up the PhD program and the PhD component of the Graduate School of Biomedical Sciences.


Research Facilities


The Department of Structural and Chemical Biology is located on the 16th floor of the Icahn Medical Institute Building, a dedicated area for basic and translational research in biomedical sciences. The department is equipped with major biophysics instrumentation in NMR spectroscopy, X-ray crystallography and Cryo-electron microscopy, as well as chemistry instrumentation and facilitates for synthetic organic chemistry and structure-based drug design. Full access is available to Minerva Supercomputer at Mount Sinai Scientific Computing Center, and advanced resources in structural biology at the New York Structural Biology Center.


Contact Us

Cevita Webb
Department Administrator
Send e-mail
Tel: 212-659-8651
Fax: 212-849 -2456

Arnaldo Medina
Administrative Assistant
Send e-mail
Tel: 212-659-8647
Fax: 212-849 -2456

Icahn School of Medicine at Mount
Sinai, Department of Structural &
Chemical Biology
One Gustave L. Levy Place, Box 1677
New York, NY 10029
Tel: 212-659-8647
Fax: 212-849-2456