The Mount Sinai Department of
Structural and Chemical Biology

The Mount Sinai Department of Structural and Chemical Biology applies experimental and computational structural biology, biophysics, and chemical biology to fundamental problems in biomedical research, with an emphasis on the molecular and structural basis of human biology and disease. Our nine research laboratories have an active development plan to recruit new faculty in both structural and chemical biology.

Scientists in the department study three-dimensional atomic structure, molecular function, and the regulation of biological macromolecules and complexes. They design and develop novel small-molecule chemicals to advance basic and translational research.

Topics of investigation include:

  • Structure and function of cell membrane-bound ion channels and receptors in cardiology and cell development

  • Molecular mechanisms of gene transcription and translation

  • Epigenetic regulation and DNA damage repair in stem cell biology, immunology, and virology

Our ultimate goal is to understand the molecular basis of human diseases such as cancer, Alzheimer's disease, and genetic disorders. State-of-the-art research, shared resources in structural and chemical biology, and regular seminars and conferences support our research and academic training.

Our mission is to:

  • Provide a nurturing environment for discovery and innovation in basic and translational biomedical research of human biology and disease

  • Advance the academic training of physicians and scientists

  • Function as a scientific hub for interdisciplinary collaborations with researchers of different disciplines to tackle the most challenging problems in biomedical sciences

Contact Us

Send e-mail
Tel: 212-659-8647
Fax: 212-849-2456

One Gustave L. Levy Place
Box 1677
New York, NY 10029