AI Finds Key Signs That Predict Patient Survival Across Dementia Types
February 28, 2024 - Researchers at the Icahn School of Medicine at Mount Sinai and others have harnessed the power of machine learning to identify key predictors of mortality in dementia patients.
Researchers Characterize the Immune Landscape in Cancer
February 14, 2024 - Researchers from the Icahn School of Medicine at Mount Sinai, in collaboration with the Clinical Proteomic Tumor Analysis Consortium of the National Institutes of Health, The University of Texas MD Anderson Cancer Center, Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, and others, have unveiled a detailed understanding of immune responses in cancer, marking a significant development in the field.
Genomic ‘tweezer’ ushers in a new era of precision in microbiome research
January 4, 2024 - In a landmark study recently published in the journal Nature Methods, researchers at the Icahn School of Medicine at Mount Sinai have unveiled mEnrich-seq—an innovative method designed to substantially enhance the specificity and efficiency of research into microbiomes, the complex communities of microorganisms that inhabit the human body.
Novel Genetic Priority Score Unveiled to Enhance Target Prioritization in Drug Development
January 3, 2024 - Driven by the need for a better way to prioritize targets for drug development, the Icahn School of Medicine at Mount Sinai has led the development of a novel “genetic priority score” (GPS) that will integrate various types of human genetic data into a single easy-to-interpret score.
Mount Sinai researchers develop novel method to improve disease prediction across diverse ancestries
December 20, 2024 - A team of scientists from Icahn School of Medicine at Mount Sinai has developed a groundbreaking statistical technique, “BridgePRS,” to enhance disease prediction in people of non-European ancestry, particularly those of African descent.
Unlocking the Human Genome: Innovative Machine Learning Tool Predicts Functional Consequences of Genetic Variants
December 14, 2023 - In a novel study, researchers from the Icahn School of Medicine at Mount Sinai introduced LoGoFunc, an advanced computational tool that predicts pathogenic gain- and loss-of-function variants across the genome.
Mount Sinai Researchers Find More Than 4,700 Gene Clusters Crucial for Prognosis in 32 Cancer Types
November 13, 2023 - Researchers at the Mount Sinai Center for Transformative Disease Modeling have released a groundbreaking study identifying 4,749 key gene clusters, termed “prognostic modules,” that significantly influence the progression of 32 different types of cancer.
Mount Sinai Launches Discovery and Innovation Center in Midtown West
October 5, 2023 - The Mount Sinai Discovery and Innovation Center core facilities, located at 787 11th Avenue, will include a Stem Cell Engineering Core, the Center for Advanced Genomics Technology, Assay Development and Screening, the Center for Therapeutic Antibody Development, the Proteomics and Metabolomics Core, the Microscopy and Advanced Bioimaging Core, and a Flow Cytometry Core.
Unveiling Asthma's Molecular Secrets: How Blood Molecules Influence Airway Processes
September 20, 2023 - A new study by researchers at the Icahn School of Medicine at Mount Sinai has unraveled the intricate molecular interplay between systemic processes within the blood and localized processes within the airways of individuals with asthma.
Mount Sinai Researchers Uncover Early Signs in Gut Bacteria That Could Predict Peanut Allergy Development
August 28, 2023 - A new study led by researchers at the Icahn School of Medicine at Mount Sinai has revealed key differences in gut bacteria and their metabolic byproducts in infants that may predict the development of peanut allergies by mid-childhood.
Ovarian Cancer: New Biological Markers Found That May Predict Which Patients Won't Respond to Chemotherapy
August 3, 2023 - Using a novel proteogenomic strategy and a variety of machine learning tools, investigators from the Icahn School of Medicine at Mount Sinai and colleagues have identified a 64-protein signature that may predict a subset of ovarian cancer patients who are unlikely to respond to chemotherapy.
Mount Sinai Alzheimer’s Researcher Is the First Woman to Win Prize From Prestigious German Research Institute
July 12, 2023 - Alison M. Goate, DPhil, the Jean C. and James W. Crystal Professor and Chair of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, has been selected as the first female recipient of the Hartwig Piepenbrock-DZNE Prize for her outstanding contributions to research into Alzheimer’s disease and frontotemporal dementia.
Researchers Show That a Machine Learning Model Can Improve Mortality Risk Prediction for Cardiac Surgery Patients
May 17, 2023 - A machine learning-based model that enables medical institutions to predict the mortality risk for individual cardiac surgery patients has been developed by a Mount Sinai research team, providing a significant performance advantage over current population-derived models.
Mount Sinai researchers discover novel receptors for SARS-CoV-2 and their age-dependent expression, providing new insights for public health
April 11, 2023 - A study led by Mount Sinai researchers has identified potential novel receptors for SARS-CoV-2 and unveiled their tissue-specific and age-dependent expression.
Genetic Causes of Three Previously Unexplained Rare Diseases Identified
March 16, 2023 - Using a new computational approach they developed to analyze large genetic datasets from rare disease cohorts, researchers at the Icahn School of Medicine at Mount Sinai and colleagues have discovered previously unknown genetic causes of three rare conditions: primary lymphedema (characterized by tissue swelling), thoracic aortic aneurysm disease, and congenital deafness.
Mount Sinai researchers discover key role of DNA methylation in Alzheimer's disease
February 22, 2023 - Mount Sinai researchers shed new light on the role of DNA methylation in Alzheimer's disease (AD).
Mount Sinai researchers discover novel mechanism for MRSA virulence
January 23, 2023 - Researchers at Mount Sinai, in collaboration with researchers at New York University. shed light on the mechanisms behind the severity, or virulence, of methicillin-resistant Staphylococcus aureus (MRSA) blood stream infections.
Digital Marker for Coronary Artery Disease Built by Researchers at Mount Sinai
December 20, 2022 - Using machine learning and clinical data from electronic health records, researchers at the Icahn School of Medicine at Mount Sinai in New York constructed an in silico, or computer-derived, marker for coronary artery disease (CAD) to better measure clinically important characterizations of the disease.
Sites in the Brain Where RNA Is Edited Could Help to Better Understand Neurodevelopment and Disease
November 1, 2022 - Mount Sinai researchers have catalogued thousands of sites in the brain where RNA is modified throughout the human lifespan in a process known as adenosine-to-inosine (A-to-I) editing, offering important new avenues for understanding the cellular and molecular mechanisms of brain development and how they factor into both health and disease.
Targeting One Type of Immune Cell With Another Slows Cancer Growth in Preclinical Studies
October 25, 2022 - A new approach to cancer immunotherapy that uses one type of immune cell to kill another—rather than directly attacking the cancer—provokes a robust anti-tumor immune response that shrinks ovarian, lung, and pancreatic tumors in preclinical disease models, according to researchers at the Icahn School of Medicine at Mount Sinai in New York.
Researchers Identify Flu-Fighting Pathways and Genes Essential for Influenza A Immune Defense
October 5, 2022 - Researchers have identified the gene TDRD7 as a key regulator against influenza A virus (IAV), which causes respiratory tract infections in 5 to 20 percent of the human population. These findings could facilitate the development of novel therapeutic interventions against influenza virus infection.
Researchers Identify a Potential Path Against Inherited Neurological Disease
September 8, 2022 - Scientists at the Icahn School of Medicine at Mount Sinai in New York, the National Center for Advancing Translational Sciences (NCATS), and elsewhere have reversed the effects of several life-threatening inherited neurodegenerative diseases called lysosomal storage disorders (LSDs) in patient cells and mice.
Mount Sinai Launches Large-Scale Genetic Sequencing Project with the Regeneron Genetics Center
August 12, 2022 - Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai have launched a new human genome sequencing research project called the Mount Sinai Million Health Discoveries Program with the Regeneron Genetics Center (RGC), part of the industry-leading, New York-based biotechnology company Regeneron.
Mount Sinai Awarded Three-Year Grant to Explore Therapeutic Approaches to KRAS Mutant Lung Tumors
August 9, 2022 - Mount Sinai is leading a team of lung cancer researchers that has been awarded a three-year, $500,000 grant from Stand Up To Cancer® (SU2C) to explore therapeutic approaches to lung tumors with mutations in the KRAS gene, an undertaking that could have a significant impact for a large population of cancer patients who currently lack effective treatment options.
Researchers Gain Insights Into the Genetic and Molecular Machinery that Predisposes Individuals to Alzheimer’s Disease
August 5, 2022 - Mount Sinai researchers have achieved an unprecedented understanding of the genetic and molecular machinery in human microglia—immune cells that reside in the brain—that could provide valuable insights into how they contribute to the development and progression of Alzheimer’s disease (AD).
Mount Sinai Designated as National Cancer Institute Proteogenomics Data Analysis Center
July 14, 2022 - The Office of Cancer Clinical Proteomics Research at the National Cancer Institute (NCI) has awarded $4.2 million over five years to Mount Sinai researchers establishing a Proteogenomic Data Analysis Center (PGDAC) to advance cancer research and treatments. Proteogenomics, which studies the roles of proteins and genes within a cell or organism, is a crucial area of exploration to further our understanding of cancer.
Mount Sinai Microbiome Lab Joins NIH’s Accelerating Medicines Partnership
May 19, 2022 - In this newly funded study, Dr. Jose Clemente and team will try to reconstruct and analyze how the microbiome may work in several autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and Sjögren’s disease.
Scientific Consortium Established by National Institutes of Health Provides Real-Time Risk Assessment of SARS-CoV-2 Variants on Immune Protection
March 31, 2022 - Program employs a coordinated approach and serves as a template for response against rapidly evolving pandemic pathogens
Scientific Consortium Established by National Institutes of Health Provides Real-Time Risk Assessment of SARS-CoV-2 Variants on Immune Protection
March 31, 2022 - Program employs a coordinated approach and serves as a template for response against rapidly evolving pandemic pathogens
Novel CRISPR Imaging Technology Reveals Genes Controlling Tumor Immunity
March 15, 2022 - Next-generation spatial genomics technology paves the way for accelerating the discovery of new cancer drug targets
Are Scientists Being Fooled by Bacteria?
February 3, 2022 - Previous studies of a genetic on/off switch may have been confounded by contamination, but Mount Sinai scientists have created a new tool for accurately determining whether it plays a role in human disease.
Most “Pathogenic” Genetic Variants Have a Low Risk of Causing Disease
January 25, 2022 - Results of large biobank study by Mount Sinai researchers may help doctors better assess true disease risk.
Could Gene Networks Resembling Air Traffic Explain Arteriosclerosis?
January 12, 2022 - Mount Sinai-led study suggests that nearly 60 percent of the risk associated with coronary artery disease may be explained by the activity of multi-organ, gene networks orchestrated by fat processing hormones
Can a Human Microglial Atlas Guide Brain Disorder Research?
January 6, 2022 - Mount Sinai-led study supports links between the brain’s immune cells and some cases of Alzheimer’s or Parkinson’s disease
Mount Sinai Alzheimer’s Researcher Wins Rainwater Prize for Outstanding Innovation in Neurodegenerative Research
December 14, 2021 - The Rainwater Charitable Foundation has named Alison M. Goate, DPhil, the Jean C. and James W. Crystal Professor and Chair of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, as this year’s winner of the Rainwater Prize for Outstanding Innovation in Neurodegenerative Research. The prize recognizes Dr. Goate’s “significant contribution to our understanding of tau-related diseases,” such as Alzheimer’s disease and frontotemporal dementia.
Scientists Show How Bone-Bordering Cells May Help Shape a Skull
December 9, 2021 - Mount Sinai study of mice searched for the cells and genes that may orchestrate how skull bones are joined together
National Organization for Rare Disorders Designates The Mount Sinai Hospital as a Center of Excellence
November 4, 2021 - The National Organization for Rare Disorders (NORD) has designated the Division of Medical Genetics and Genomics at The Mount Sinai Hospital as a Rare Disease Center of Excellence. With this designation, Mount Sinai will join a highly selective nationwide network of 31 medical centers that specialize in rare disease diagnosis, treatment, and research
Childhood Asthma Study Uncovers Risky Air Pollutant Mixtures
October 6, 2021 - Mount Sinai researchers use a novel machine learning algorithm to discover that early exposure to a variety of toxic air pollutants can lead to poor asthma outcomes
Schizophrenia Study Suggests Advanced Genetic Scorecard Cannot Predict a Patient’s Fate
September 7, 2021 - Mount Sinai study showed that polygenic risk scores were no better at predicting whether a patient’s symptoms worsened than written reports
Mount Sinai Researchers Find Important Clue to Rare Inflammatory Disease in Children Following COVID-19 Infection
August 12, 2021 - Mount Sinai researchers have found an important clue to a rare but serious aftereffect of COVID-19 in children, known as multisystem inflammatory syndrome in children or MIS-C.
Genetic Ancestry Versus Race Can Provide Specific, Targeted Insights to Predict and Treat Many Diseases
April 14, 2021 - Complex patterns of genetic ancestry uncovered from genomic data in health care systems can provide valuable insights into both genetic and environmental factors underlying many common and rare diseases
Mount Sinai Study Reveals Genetic and Cellular Mechanisms of Crohn’s Disease
March 31, 2021 - New study identifies a novel approach for tailored treatment that could be more effective for patients with the chronic disease
Mount Sinai Researchers Identify and Characterize Three Molecular Subtypes of Alzheimer’s Disease
January 6, 2021 - Critical Step Toward Developing Precision Medicine Treatments
Multi-Population Risk Scores Could Improve Risk Prediction for Inflammatory Bowel Diseases, Study Finds
December 24, 2020 - New study illustrates how studying diverse populations can help predict patient outcomes and reduce health disparities
First large-scale, multicenter proteogenomic analysis offers new insights into pediatric brain tumor biology
November 25, 2020 - Data reported can guide new therapeutic avenues for pediatric patients
Potential New Therapies for Alzheimer’s Disease are Revealed through Network Modeling of Its Complex Molecular Interactions
November 24, 2020 - Researchers from Mount Sinai and the National Center for Geriatrics and Gerontology in Japan have identified new molecular mechanisms driving late-onset Alzheimer’s Disease (LOAD), as well as a promising therapeutic candidate for treatment
Alison M. Goate Named Chair of Genetics and Genomic Sciences at Icahn School of Medicine at Mount Sinai
November 19, 2020 - Noted Alzheimer’s researcher will assume new role on January 1, 2021
Mount Sinai Receives Microsoft AI for Health Grant to Support Center Dedicated to Data Science Discovery for COVID-19
June 8, 2020 - Grant Will Enable Development of AI Tools to Enhance Care and Evidence-based Medicine for Treating COVID-19 Patients
Mount Sinai Study Finds First Cases of COVID-19 in New York City are Primarily from European and US Sources
June 2, 2020 - First definitive molecular epidemiology study of SARS-CoV-2 in New York City to describe the route by which the virus arrived
Mount Sinai Researchers: Why COVID-19 May Be Less Common in Children Than Adults
May 5, 2020 - Findings Published in JAMA Could Lead to Potential Biomarker of Susceptibility
Mount Sinai Launches App and First Campaign of The Resilience Project to Develop New Treatments and Preventive Care for Diseases
April 13, 2020 - Lyme Campaign Seeks Participants Who Are ‘Resilient’ to the Tick-borne Disease
Mount Sinai Launches COVID-19 App to Track Spread of Virus Across New York City
April 1, 2020 - A team of data scientists, physicians, and engineers across the Mount Sinai Health System has come together to launch STOP COVID NYC, a web-based app to capture the symptoms and spread of COVID-19 in New York City
Airway Microbiome and Host Interact Differently in Children with Severe Asthma
March 12, 2020 - The Mount Sinai study showed that airway microbes interact with inflammatory genes differently in healthy versus asthmatic children.
Researchers Identify Opportunities to Advance Genomic Medicine
January 27, 2020 - New Study Highlights Milestones in the History of Genetic Discoveries; Equitable and Fair Access Required to Address Disparities
Researchers Show Different Mutations in a Single Gene Can Wreak Many Types of Havoc in Brain Cells
December 19, 2019 - NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous deletions in NRXN1 are strongly associated with neuropsychiatric disorders. The study published in Nature Genetics reported links to patient-specific, heterozygous intragenic deletions in NRXN1 to isoform dysregulation and impaired neuronal maturation and activity in a human and disease-relevant context.
December 12, 2019 - Researchers at the Icahn School of Medicine at Mount Sinai have identified novel genes associated with the severity of peanut allergy, as well as ways in which these genes interact with other genes during allergic reactions. The findings, published in the Journal of Allergy and Clinical Immunology, could lead to better treatments for peanut allergy.
Genetic Breakthrough Identifies Heart Failure Risk in African and Latino Americans
December 10, 2019 - A genetic variation believed to increase risk for heart failure in people of African or Latino ancestry has been identified in a new study by researchers from the Icahn School of Medicine at Mount Sinai and Perelman School of Medicine at the University of Pennsylvania. The study found that the transthyretin or TTR V122I genetic variant was significantly associated with heart failure and that heredity transthyretin amyloid cardiomyopathy (hATTR-CM) caused by this variant was confirmed at appreciable frequency in individuals of African or Latino ancestry. The results were published in JAMA.
New Discovery in C. difficile Biology Could Lead to Treatments for Dangerous Bacterial Infections
November 25, 2019 - A process called sporulation that helps the dangerous bacterium Clostridium difficile (C. difficile) to survive inhospitable conditions and spread is regulated by epigenetics, factors that affect gene expression beyond the DNA genetic code, researchers at the Icahn School of Medicine at Mount Sinai report. This is the first discovery that epigenetics regulate sporulation in any bacteria. Their research, published November 25th in Nature Microbiology, opens a new window to developing treatments for this devestating infection.
Mount Sinai Researchers Uncover New Molecular Drivers of Parkinson’s Disease
November 20, 2019 - Scientists at the Icahn School of Medicine at Mount Sinai have uncovered new molecular drivers of Parkinson’s disease using a sophisticated statistical technique called multiscale gene network analysis (MGNA). The team was also able to determine how these molecular drivers impact the functions of genes involved in the disease. The results were published in Nature Communications.
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