Brain Imaging Center (BIC)
Over the last three decades, we have seen unprecedented progress in the study of the brain. State-of-art brain imaging has allowed a first-time glimpse into the structure, functioning, and connectivity of the human and non-human brain in both healthy and disease states -- findings of broad relevance across medical research and clinical programs. The Icahn School of Medicine at Mount Sinai (ISMMS) has built a new relational bridge between the Translational and Molecular Imaging Institute (TMII) and The Friedman Brain Institute (FBI) to accelerate use of these cutting-edge imaging tools to further research into the workings of the brain. Known as the Brain Imaging Core (BIC), BIC is designed to enhance research efforts within and outside the institution by providing investigators with high-level expertise in the collection and analysis of precise structural and functional images of living brains. Mount Sinai is also a research leader in developing a dynamic map of the shared and distinct mechanisms involved in the brain's complex functioning in both healthy brains and brains affected by a range of neuropsychiatric diseases.
Areas of Research
- Brain morphology, function, and microstructure
- Resting and task-based functional connectivity
- Brain chemistry, metabolism, and physiology
- Multimodal imaging
- Development of novel imaging techniques
- Identifying neuropsychological mechanisms including at-risk endophenotypes
- Big data, data mining, computational modeling, and comparative studies
Advances in Research
TMII provides BIC-affiliated laboratories with cutting-edge, optimized neuroimaging tools, supported by advanced study design and analysis expertise. The standardized BIC protocol offers participating researchers a straightforward and well-supported process for inclusion of structural and functional brain imaging in their investigations. Affiliated scientists are also able to draw on the comparative value afforded by the emerging BIC neuroimaging dataset, for data mining and computational modeling.
Rita Z. Goldstein, PhD, Professor of Psychiatry and Neuroscience, and BIC's Chief, envisions a growing number of BIC-affiliated laboratories, spanning multiple ISMMS departments, with shared interests that cross both departmental and institutional lines.
For investigators at Mount Sinai, as well as those at collaborating research institutions, BIC can provide a standardized and well- characterized set of brain scans, pipelined with a common protocol for pre-processing and analysis. The availability of established and expertly-supported modalities for high-resolution brain imaging across research areas of interest will provide reliable, relatable information about brain morphology, function, and microstructure, as well as information about resting- and task-based functional connectivity in healthy brains and brains affected by disease.