Genomics is a new field and its rapid ascent from research to clinical practice has left the current provider workforce largely unprepared. This mismatch of emerging clinical validity and lack of physician preparedness requires a solution that consolidates and translates genomic knowledge and integrates this knowledge into existing clinical workflows. However, such solutions do not exist at this time. The emergence of Electronic Health Records (EHR’s) in mainstream healthcare together with their inherent ability to provide point of care Clinical Decision Support (CDS) has the potential to provide the necessary level of point-of-care personalized guidance. The Clinical Implementation of Personalized Medicine through Electronic Health Records and Genomics (CLIPMERGE) Program at Mount Sinai implements a novel clinical decision support (CDS) engine for delivering guidelines with genetic variants of clinical significance in a way that integrates with busy physician work processes.