The Head and Neck Cancer Research Program at Mount Sinai aims to perform research that will lead to new insights into head and neck cancer biology and new strategies for treatment.

We have developed a multidisciplinary program that will provide new understanding into the molecular, pathological, and immunological basis of head and neck cancers, and provide a platform for rapid translation of basic discoveries to clinical trials.

The last two decades have seen great advances in understanding of the molecular, cellular, and physiological mechanisms driving tumor formation, metastasis, and persistence of residual disease. These advances include increased understanding of the genetic and epigenetic heterogeneity of cancers; the complexity of tumor-host crosstalk, including immune subversion and escape; and the elucidation of specific molecular pathways supporting the growth and survival of tumor cells.

While our primary focus is squamous cell carcinoma of the upper aerodigestive tract (HNSCC), individual projects will also address salivary, thyroid, and cutaneous malignancies including melanoma. Our program includes a core of basic molecular, cell and cancer biologists as well as physician-scientists who work collaboratively towards improved understanding and treatment of head and neck cancers. Integration of basic, translational, and clinical research programs will allow rapid development of fundamental insights into useful tools for physicians. Through a truly multidisciplinary approach uniting disparate areas of cancer research and treatment we will accelerate discovery of new diagnostic, prognostic, and therapeutic tools to fight head and neck cancer.

We invite other members of the Mount Sinai community and other academic and industry partners to collaborate on research initiatives including multidisciplinary grants, shared equipment grants, program project grants, and other funding opportunities.

Contact Us

Andrew Sikora, MD, PhD
Director, Head and Neck Translational Research
Tel: 212-659-9516
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Julio Aguirre-Ghiso, PhD
Director, Head and Neck Cancer Basic Research
Tel: 212-241-9582
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Mariko Stronach
Research Program Coordinator
Tel: 212-241-9144
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