Genomics of Chronic Allograft Rejection
We are using microarray technology to help understand mechanisms of transplant rejection. GeneChip technology allows simultaneous detection of thousands of genes. This broad spectrum approach to the molecular analysis of a complex disease, such as chronic rejection, will allow us to better understand the pathogenic mechanisms and help refine diagnosis and treatment. In a related line of investigation, we are focusing on kidney transplantation recipients that develop antibodies to their donor following transplant, in order to determine if the development of donor specific antibodies leads to the development of transplant glomerulopathy and examine whether theses patients can be identified before they become sensitized.