Department of Stem Cell Biology and Regenerative Medicine

The Department of Stem Cell Biology and Regenerative Medicine (SCBRM) is positioned at the core of the Mount Sinai Health System, which provides valuable access to patient data and biological samples. The Icahn School of Medicine at Mount Sinai is ranked No. 4 in the United States for Cell Biology in the 2026-2027 U.S. News & World Report® Best Global Universities rankings. Our mission is to realize the potential of stem cell biology and regenerative medicine to identify new approaches to treat human disease and promote healthy aging.

Collaborative Research and Translational Impact

SCBRM brings together world-leading basic researchers using animal model systems to uncover the principles of developmental biology and tissue regeneration, and stem cell biologists and bioengineers who apply this knowledge to generate human stem cell-derived cells and organoids. These platforms are critical for developing robust human disease models, high-throughput drug screening, and advancing therapeutic transplantation techniques.”

Our interdisciplinary research portfolio and collaborative programs are generating crucial new insights into a broad spectrum of medical conditions, including: wound repair; hair loss; infertility; lung and liver disease; muscle wasting; congenital diseases affecting the craniofacial, hematopoietic, cardiac, and immune systems; neurodevelopmental conditions such as autism; neurodegenerative diseases including Alzheimer’s and Parkinson’s; childhood and adult cancers; and the fundamental processes of aging.

Integrated Centers and Clinical Acceleration

SCBRM researchers are active participants in the Tisch Cancer Institute, the Friedman Brain Institute, the Mindich Child Health & Development Institute, the Institute for Airway Sciences, the Diabetes, Obesity & Metabolism Institute, and the Sinai Skin Biology & Diseases Resouce-based Center, among other major interdisciplinary centers. We work closely with surgical teams to develop novel procedures involving stem cell-derived tissues and collaborate extensively with clinicians across the Health System to accelerate the translation of foundational discoveries into clinical applications.

Training and Scientific Leadership

SCBRM provides an exceptional environment for training the next generation of scientific leaders. Graduate students and postdoctoral fellows are directly engaged in cutting-edge research across diverse model systems and experimental platforms, benefiting from close mentorship and interdisciplinary collaboration. Department faculty are deeply committed to Mount Sinai's graduate and medical education programs, fostering the scientific curiosity, technical excellence, and innovative thinking required for leadership roles in academia, the biotechnology industry, and clinical medicine.

Under the leadership of its chair, Dr. Sarah Millar, SCBRM is focused on advancing regenerative therapies, sustaining excellence in training, and building the foundational knowledge for a new era in stem cell and regenerative biology that promises to fundamentally reshape our understanding, preservation, and restoration of human health.