Myeloproliferative Disease Program (MPD)

The MPD Program at Mount Sinai is a comprehensive program in the Northeast for treatment of patients with myeloproliferative neoplasms, including:

  • Polycythemia Vera
  • Essential Thrombocythemia
  • Chronic Myeloid Leukemia
  • Primary Myelofibrosis
  • Hypereosinophilic syndrome
  • Mastocytosis
  • Acute leukemia arising from a MPN

This program is under the direction of internationally renowned hematologist Ronald Hoffman, MD.


The Myeloproliferative Disease (MPD) Program at Icahn School of Medicine is composed of a robust clinical trials arm and a large laboratory based arm.

The clinical component offers a number of phase I/II/III experimental therapies for patients with Myelofibrosis, Polycythemia Vera, Essential Thrombocythemia, and Chronic Myeloid Leukemia. Dr. John Mascarenhas is primarily responsible for the conduct of the clinical trials.

The central focus of the laboratory work of Drs. Hoffman, Vesna Najfeld, Anna Rita Migliaccio, Min Lu, Xiaoli Wang, Pratima Chaurasia, and Camelia Iancu-Rubin centers on defining the molecular underpinnings of these neoplasms and identifying and testing novel agents in preclinical studies that will one day be used in early phase clinical trials.

Mount Sinai is the lead site and Dr. Hoffman is the Principal Investigator of a NCI-sponsored program project grant for the 35-member international Myeloproliferative Disorders Research Consortium (MPD-RC) that was awarded funding for an additional 5 years. The MPD team also includes the Clinical Research Program Manager, Jill Kleczko, Clinical Research Coordinators: Lonette Sandy and Sarah Han, the Research Nurse, Carrie Newsom; the Research Protocol Managers: Jimmy Siuty and Jane Lew, a MPD-RC Data Monitor, Crystal Miller, a Regulatory Coordinator, Aniceto Javaluyas, a Physician Assistant Evgeny Mikler; MPD-RC Administrator, Minu Chaudhuri; MPD-RC Administrative Coordinator, Yesenia Pichardo; and an Executive assistant, Daniel Hathaway.

Contact Us

For patient referrals please call 1-800-563-1699

To make an appointment at the Myeloproliferative Disorders Program Please call 212-241-2297 or (800) 537-2245.

Be sure to bring with you any recent laboratory or other relevant test results.

In this episode of "Healthy Body, Healthy Mind" Mount Sinai's John Mascarenhas, MD, discusses myelofibrosis - including why it's an unfamiliar term for many people, the rarity of the disease, and the age at which most people are diagnosed. Watch Video