Department of Genetics and Genomic Sciences
We are shaping the future of genomic research, medicine, and education in the largest, most diverse healthcare system in New York City
By leveraging a legacy of excellence, a team of world-class geneticists and researchers, and access to one-of-a-kind resources and collaborations, we bring pioneering ideas to life.
Fueled by Mount Sinai’s Precision Medicine Initiative, our Department’s innovative, interdisciplinary approach sets it apart from any other genetics and genomics program in the world.
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Latest Publications
Wroblewska, A., Dhainaut, M., Ben-Zvi, B., Rose, S.A., Park, E.S., Amir, E.-A.D., Bektesevic, A., Baccarini, A., Merad, M., Rahman, A.H., et al. Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens. Cell.
Raj, T., Li, Y.I., Wong, G., Humphrey, J., Wang, M., Ramdhani, S., Wang, Y.-C., Ng, B., Gupta, I., Haroutunian, V., et al. (2018). Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer’s disease susceptibility. Nature Genetics.
Holmes, G., O’Rourke, C., Motch Perrine, S.M., Lu, N., van Bakel, H., Richtsmeier, J.T., and Jabs, E.W. (2018). Midface and upper airway dysgenesis in FGFR2-related craniosynostosis involves multiple tissue-specific and cell cycle effects. Development 145.
Lin, L., Chen, Q., Hirsch, J.P., Yoo, S., Yeung, K., Bumgarner, R.E., Tu, Z., Schadt, E.E., and Zhu, J. (2018). Temporal genetic association and temporal genetic causality methods for dissecting complex networks. Nature Communications 9, 3980.
Wang, L., Saci, A., Szabo, P.M., Chasalow, S.D., Castillo-Martin, M., Domingo-Domenech, J., Siefker-Radtke, A., Sharma, P., Sfakianos, J.P., Gong, Y., et al. (2018). EMT- and stroma-related gene expression and resistance to PD-1 blockade in urothelial cancer. Nature Communications 9, 3503.
Hoffman, G.E., Schadt, E.E., and Roussos, P. (2018). Functional Interpretation of Genetic Variants Using Deep Learning Predicts Impact on Epigenome. BioRxiv.
Icahn Institute for Data Science and Genomic Technology
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