Laboratories

As a student in our Cancer Biology Graduate Training Program, you will devote a significant portion of your time to research. Explore our Cancer Biology laboratories and learn about our investigators.

Lab NameDescription
Aaronson Laboratory Investigating genetic alterations that contribute to cancer with the goals of identifying novel targets and new cancer therapies, utilizing state of the art molecular and cell biological technologies
Aguirre-Guiso Laboratory of Signaling and Mestasis Exploring the biology of disseminated tumor cells, focusing on mechanisms of survival, dormancy, and growth of loco-regional or secondary organ disseminated tumor cells
Baron Laboratory Researching hematopoietic and vascular development in mice; regulation of stem cell proliferation, survival, and differentiation; gene regulation; primitive and definitive endodermal lineages; and angiogenesis
Bernstein Laboratory (Emily) Exploring epigenetic regulation of gene expression in multiple biological pathways including cancer, cellular senescence and stem cell biology
Boffetta - Cancer Prevention and Control Division Research Researching safer and more effective cancer treatments
Bravo-Cordero Laboratory Studying tumor cell invasion and migration during cancer metastasis by using imaging approaches including live-cell imaging, FRET microscopy and intravital two-photon imaging
Burakoff - Tisch Cancer Center Research Exploring dendritic cell and macrophage immune dysregulation in the tumor micro-environment; developing preclinical models to restore immunogenicity to tumor associated antigens; and translating these discoveries into cancer immunotherapy trials
Jia Chen Elucidating effects of environment and lifestyle factors (e.g. pollutants, stress, nutrients) on the epi/genome (e.g. transcriptome, methylome, microRNA, imprintome) and their ultimate impact on cancer and other human diseases
Chen Laboratory Focusing on the identification and development of novel cancer therapeutic modalities that are able to reconstruct the antitumor response by utilizing a combination of the host immune system and the mechanisms of cancer biology
Chipuk Laboratory Studying how the shape and composition of the mitochondrial network impacts on cell biology within the context of human disease
Dar Laboratory Studying signal transduction networks at multiple levels: structurally, biochemically, within cells, and also within whole animals
Dominguez-Sola Laboratory Understanding how cancer initiation shapes the biological features and natural history of this disease, specifically in models of aggressive B cell lymphoma
Domino-Domennech Laboratory Investigating the molecular and cellular pathogenesis of cancer, primarily in prostate and bladder tumors
Ezhokova Laboratory Elucidating the molecular mechanisms of skin homeostasis and tumorigenesis
Fisher Laboratory Understanding regulation of cell division and gene expression through chemical-genetic manipulation of cyclin-dependent kinases
Germain Laboratory Focusing on breast cancer research, using a combination of cell biology and mouse genetics approaches, to investigate the link between pregnancy and breast cancer and the role of the mitochondrial unfolded protein response in breast cancer progression
Ginsburg Laboratory Focusing on research in erythropoiesis and iron metabolism, using a combination of cell biology and mouse genetics approaches, to investigate the role of iron transport in erythroid differentiation, proliferation, and apoptosis
Irie Laboratory Focusing on the role of oncogenese such as Akt regulate processes in breast cancer and identifying novel regulators of anoikis resistance for novel therapeutic targets in breast cancer treatment
Itzkowitz – Gastrointestinal Cancer Research Laboratory Studying the role of trefoil factors in gastrointestinal cancer biology
LeRoith Laboratory Understanding the role of insulin and insulin-like growth factors in health and disease, including the factors which explain the increased risk of cancer, especially triple negative breast cancer, and cancer-related mortality in obesity and type 2 diabetes
Lujambio Laboratory Studying mechanisms of liver cancer initiation and maintenance, specifically how genetic alterations in cancer cells contribute to tumorigenesis, alter treatment response, and create vulnerabilities that may be targeted therapeutically
Manfredi – Tisch Cancer Institute Research Researching the role of the tumor suppressor p53 and its pathway in regulation of gene regulation and tumorigenesis in cells and mouse models
Montgomery-Schnur Research: Integrative Behavioral Medicine Program Researching integrative and behavioral medicine interventions to improve quality of life for individuals with cancer
O’Connell Laboratory Focusing on two related aspects of the biology that controls the integrity of the genome 1) Cell division cycle and signaling pathways, and 2) Determinants of chromosome structure
Pan Laboratory Investigating the role of ubiquitin signaling in cancer biology using biochemical, molecular biology and chemical biology approaches
Papapetrou Laboratory Studying myeloid malignancies to understand disease mechanisms and to identify new therapeutic targets using patient-derived induced pluripotent stem cells (iPSCs) and genome editing technologies (CRISPR and others)
Parekh Laboratory Studying genetic and epigenetic variation contribution to aberrant gene expression in B cell malignancies, particularly non-Hodgkins Lymphoma and Multiple Myeloma, using an integrated systems biology approach
Parsons Laboratory Combining molecular pathology and genetic tumor biopsies, human and mouse tumor models, metabolism, epigenetics, and biochemistry of signaling
Pfleger Laboratory Employing the synergistic systems of in vivo Drosophila (fruit fly) genetics, tissue culture, and in vitro biochemistry to: 1) investigate Ras signaling, the Hippo Tumor Suppressor Pathway, and the Ubiquitin Pathway, and 2) to develop fly models of human disease
Poulikakos Laboratory Investigating pharmacologic targeting of oncogenic signaling. We are focused on understanding mechanisms of sensitivity and resistance to small molecule inhibitors and use this knowledge to design more effective therapeutic strategies in cancer.
Reddy Laboratory Developing novel, targeted therapies for cancer, through understanding the oncogenic signaling that mediates the proliferative and metastatic behavior of cancer cells and identifying specific targets that can be inhibited by small molecule inhibitors
Rodriguez-Bravo Laboratory Studying genome integrity maintenance mechanisms during cell proliferation and the impact of nuclear pores and chromosomal defects on cancer cells aggressiveness and survival to current therapies
Silva Laboratory Researching into the characterization of the breast cancer genome and identification of novel breast cancer targeted therapies through functional genomics
Skobe Laboratory Exploring the mechanisms of cancer metastasis, tumor microenvironment and the biology of lymphatic vasculature in health and disease
Ting Research Studying how the tumor necrosis factor (TNF) regulates cell death at the mechanistic level and in turn, how this process controls immune responses to infection, organ transplant and cancer.
Villanueva Laboratory Analyzing molecular heterogeneity and drivers of cancer evolution in hepatocellular carcinoma, and developing novel prognostic and predictive biomarkers using minimally invasive approaches (i.e., liquid biopsy)
Wassarman Laboratory Investigating the molecular basis of gamete interactions during fertilization in mammals.
Yu Laboratory Researching to: 1) identify key therapeutic targets that play essential roles in cancer initiation, progression, and therapeutic resistance; 2) understand underlying mechanisms; and 3) develop therapeutic agents and combinations against these targets to hopefully slow down and/or stop a variety of cancers.