Clinical Genetics Laboratory Training Program

For more than 40 years, a comprehensive clinical, educational and research program in human and medical genetics has existed at Icahn School of Medicine at Mount Sinai. Our faculty provides comprehensive genetic testing services that are available through cytogenetic, biochemical and molecular laboratories. In addition, there are clinical genetic services and specialty programs in metabolic disease, congenital anomalies, cardiovascular genetics, cancer genetics and others as well as a program of basic and clinical research supported by more than $15 million in research grants and involving the efforts of more than 100 faculty and staff members.

We designed these innovative programs specifically to prepare the next generation of geneticists to meet the challenges resulting from the delineation of the molecular basis of inherited and common disorders. At the completion of their training, they will be uniquely qualified to apply the diagnostic and therapeutic advances developed in laboratories across the nation, including molecular diagnosis, gene therapy, and gene product replacement therapy. We offer the following comprehensive training programs.

The Department of Genetics and Genomic Sciences serves as an accredited training site for the following medical genetics and medical education organizations:

How to Apply to Our Programs

Generally, we ask all incoming fellows entering their first specialty of training at the Icahn School of Medicine at Mount Sinai to commit to two years of laboratory training, regardless of previous ABMG training at another institution.

To apply, you must submit the following materials:

Send all materials, preferably via e-mail to genetics.residency@mssm.edu, or by mail to Stuart Scott or Yvette Dingwall at the Icahn School of Medicine at Mount Sinai, Clinical Genetics Laboratory, One Gustave L. Levy Place, Box 1497, New York, NY, 10029-6574.

Clinical Cytogenetics

Lab Director: Lisa Edelmann, PhD

We have designed the clinical cytogenetics training program to provide trainees with the skills they will need to direct future fellowship programs, pursue a professional career, or direct a cytogenetics diagnostic laboratory. Training includes:

  • Gaining expertise in test design and validation.
  • Interpretation, troubleshooting, reporting, and communication of results to providers.
  • Proper quality control and assurance and to direct a fellowship program in the future.
  • Performing research in cytogenetic testing.

Current Trainees in Clinical Cytogenetics Genetics

Name Post Grad Year Medical School
Wahab Khan, PhD PGY-1 University of Western Ontario - Canada
Lisong Shi, PhD PGY-4

Chinese Academy of Medical Sciences and Peking Union
Medical College – Beijing, China

Ram Singh, PhD PGY-1 Maharshi Dayanand Saraswati University - Ajmer, India

Clinical Biochemical Genetics

Lab Director: Chunli Yu, MD

Experience gained from the clinical biochemical genetics training program enables our trainees to direct future fellowship programs and pursue careers or leadership roles in biochemical diagnostics. Trainees acquire the skills and gain expertise in:

  • Test design and validation.
  • Interpretation, troubleshooting, reporting, and communication of results to providers.
  • Proper quality control and assurance.
  • Performing research in biochemical genetic testing.

Current Trainee in Clinical Biochemical Genetics

Name Post Grad Year Medical School
Na Lin, PhD PGY-2  Xinhua Hospital Affiliated to Shanghai Jiao Tong
University School of Medicine

Clinical Molecular Genetics

Lab Directors: Ruth Kornreich, PhD
                       Lisa Edelmann, PhD

Focus of the clinical molecular genetics training program centers on developing the skills and experience needed to direct future fellowship programs and pursue careers and leadership roles within a molecular diagnostic laboratory. Trainees will gain expertise in:

  • Test design and validation
  • Interpretation, troubleshooting, reporting, and communication of results to providers
  • Proper quality control and assurance
  • Performing research in molecular genetic testing

Current Trainees in Clinical Molecular Genetics

Name Post Grad Year Medical School
Melanie Babcock, PhD PGY-4

Icahn School of Medicine at Mount Sinai - New York,
United States

Xiaoqiang Cai, PhD PGY-3 Wuhan University - Wuhan, China
Neal Cody, PhD PGY-2 McGill University - Montreal, Canada
Anastasia Fedick, PhD PGY-2

Rutgers-Robert Wood Johnson Medical School -
New Jersey, United States

Xingwu Lu, PhD PGY-2

Institute for Cancer Genetics – Columbia University,
New York, United States

Blake Palculict, PhD PGY-1

University of Texas – MD Anderson Cancer Center –
Texas, United States

Tulsiram Prathapam, PhD PGY-1 GENEDX – Maryland, United States
Jennifer Reiner, PhD PGY-3 Vanderbilt University – Tennessee, United States
Chen Zhao, PhD PGY-1

State University of New York – Stoney Brook – New
York, United States

Courses and Conferences

Within this training program, we require fellows to attend and complete a formal, graduate-level course in medical genetics each year. The lectures cover basic scientific underpinnings of genetic disease, clinical genetics, cytogenetics, molecular genetics, and biochemical genetics. In addition, instruction on the genetics of cancer, immunology, developmental and neurological disorders, and population and statistical genetics help round out the fellows’ formal education in the basic genetic sciences. Fellows attend the departmental Journal Club, which meets bi-weekly. Additionally, once a month each lab presents an individual Journal Club covering material that related to those respective specialties. Throughout their training, fellows are expected to attend the weekly departmental seminar presenting original research in the basic biomedical sciences.

During the weekly clinical case conference, reports on interesting patients and reviews of diagnostic tests as they pertain to Medical Genetics in the basic science and clinical literature are presented. Fellows also are scheduled to observe genetic counseling sessions.

Mandatory Courses and Conferences

  • Medical Genetics Course
  • Metabolic Didactic
  • Clinical Case Conference
  • Clinical Journal Club
  • Departmental Seminar Series

Recommended Courses and Conferences

  • Genetics and Genomic Sciences Work in Progress, Research Seminar
  • Genomics of Common Diseases Seminar
  • Special Topics in Cytogenetics
  • Cancer Genetics Journal Club
  • Advanced topics in pharmacogenomics
  • Pharmacogenomics
  • Seminar in Genetics & Genomic Sciences
  • Genetics & Genomic Sciences Core III
  • Advance Human Genetics

Conference Schedule