Functional Magnetic Resonance Imaging (fMRI)
We use fMRI to take pictures of the brain while you perform simple tasks, like playing video games. This allows us to examine the differences in brain activation between individuals with and without ADHD, or before and during treatment with a study medication. By examining differences in the processes used to make decisions and inhibit impulses, we gain insight into the mechanisms of ADHD to guide design and selection of effective treatments.
There are no known dangers associated with fMRI and to participate, you or your child must be comfortable with small spaces, have no metal in the body that cannot be removed (i.e., metal plates, screws, or braces), and meet inclusion criteria for the study that you choose.
Studies Currently Recruiting
Neurobiological Basis of Response to Guanfacine XR in Children and Adolescents with ADHD: An fMRI study of Activation Pre- and Post- Treatment
This research treatment study looks at neurobiological response to INTUNIV XR (extended release Guanfacine Hydrochloride), a non-stimulant medication with FDA approval for treatment of ADHD. Participants receive a psychiatric and physical examination with labs. Those who are diagnosed with ADHD receive an fMRI brain scan while performing neuropsychological tasks, prior to randomization to a placebo or medication group. These scans are conducted without contrast or sedation. This is a exible dose titration study, so all children start on the lowest dose of Intuniv (or placebo). Children's progress is carefully monitored during weekly visits with our study physicians during the 4 to 6 week titration and 2 week maintenance phase (total of 6-8 weeks). While still on the maintenance dose, the child receives a second fMRI scan and an abbreviated psychiatric and physical examination. To ensure that children in the placebo group have opportunity to receive treatment under our doctors supervision and to provide stabilization for children in the medication group, all children may continue to see our doctors for an additional 2 months after their participation in the study has ended. During this time, the doctors may provide a prescription an FDA approved medication other than INTUNIV, depending on their best clinical judgment and the child's responses to treatment during the study.
Visual-Spatial Working Memory in Children and Adolescents with and without ADHD: An fMRI Study of Brain Activation (Youth with ADHD and Healthy Volunteers Needed)
Researchers at Icahn School of Medicine are looking for healthy boys and girls, and boys and girls with Attention Deficit Hyperactivity Disorder (ADHD) between the ages of 9 and 15 to participate in a study exploring the brain regions people use to remember information. This study consists of one to two visits to the medical center where participants will complete a series of psychological assessments, a computer memory task, and then will undergo a functional magnetic resonance imaging (fMRI) brain scan. Reimbursement will be provided for both testing sessions.
Recently Approved Studies
Imaging Stimulant and Non-Stimulant Treatments for ADHD: A Network Based Approach
Our recent work on the study Methylphenidate and Atomoxetine in ADHD: fMRI Measures of Mechanisms and Response produced exciting findings, offering a window into the common and unique neurophysiological mechanisms of response to stimulant and non-stimulant treatments. To enhance the interpretation and clinical utility of these results, we are conducting an in-depth investigation of the impact of the two treatments on relevant neural networks, and evaluating whether improvement is achieved via normalization or other adaptive changes in brain function. As participants in the study: Imaging Stimulant and Non-Stimulant Treatments for ADHD: A Network Based Approach, healthy youth and youth with ADHD will participate in fMRI brain scanning while performing neuropsychological tasks. Only youth with ADHD will be randomized to one of the medication treatment groups. Youth receiving medication will be carefully monitored during weekly visits with our study physicians during the 6-8 week duration of participation.
Neurobiological Basis of Response to Vyvanse in Adults with ADHD: An fMRI Study of Brain Activation Pre- and Post- Treatment
Recently Closed to Enrollment
Brain Activation in Preadolescents with High vs. Low Risk for Substance Abuse
Children between 8 and 12 years old who are not currently taking medication and who may not want to commit to a long term relationship with our team may be eligible to participate in this brain imaging study using fMRI (magnetic resonance imaging) to take a picture of your child’s brain while playing a videogame. Through this study, we hope to determine whether there are differences in the way children with family histories of substance abuse respond to rewards and inhibit impulses.
Your child will receive an evaluation for ADHD and other psychiatric disorders. He or she must be comfortable with small spaces, have no metal in the body that cannot be removed (i.e., metal plates, screws, or braces), and not be taking other psychiatric medications.
Compensation is provided for time and travel expenses. Funded by NIDA/AACAP K23 PA-00-003.
For more information about participation in research
For more information about ADHD Center Clinical Programs
For more information about Learning Disorders
Center of Excellence for ADHD and Related Disorders
Icahn School of Medicine
Department of Psychiatry
One Gustave L. Levy Place
New York, NY 10029