Jul 28, 2024
In a recent interview with the New York Post, Dr. Brian Brown reveals how chronic inflammation, a common companion of aging, could be a key factor in increased cancer risk.
May 20, 2024
A team led by Yizhou Dong have designed a regenerative therapy to speed up diabetic wound repair. Using lipid nanoparticles loaded with mRNA encoding the cytokine IL-4, the treatment was shown to target dysfunctional macrophages, reduce inflammation and oxidative damage in mouse models of damaged skin.
Apr 29, 2024
As Dean, Dr. Merad will catalyze the research innovation that drives medical progress, focusing on streamlining early clinical trials at Icahn Mount Sinai, cultivating a culture of mechanistic clinical trials across campus, and forging stronger partnerships with the pharmaceutical and biotech sectors.
Mar 14, 2024
Emma Gutmann-Yassky has been honored with the 2024 Jacobi Medallion in recognition of her contributions as a physician-scientist challenging the status quo to resolve immune-mediated skin diseases and developing therapeutics bringing new hope to patients.
Feb 22, 2024
A team led by Robert Samstein and Diego Chowell has discovered variations in immune genetics that influence lung cancer risk, potentially paving the way for enhanced prevention strategies and screening. Their study suggests HLA Class II diversity plays a protective role by presenting tobacco-related antigens, aiding in early cancer cell detection by immunosurveillance.
Dec 06, 2023
Miriam Merad's team has uncovered an IL-4 signaling axis favoring the production of dysfunctional myeloid cells that suppress anti-tumor immunity in mouse models of lung cancer. An early parallel study in patients, revealed that the Interleukin-4 receptor-blocking antibody Dupilumab boosted patients' immune systems, with one out of the six experiencing significant tumor reduction.
Nov 03, 2023
Dr. Nina Bhardwaj, MD, PhD and Dr. Miriam Merad, MD, PhD were inducted into the 2023 Class of Fellows of the Academy of Immuno-Oncology by SITC. The Academy honors individuals who have launched the field of cancer immunotherapy into the breakthrough cancer treatment it is today and brings together the brightest minds in the field to continue to advance SITC, the field, and the next generation of immuno-oncologists.
Oct 09, 2023
Dr. Merad's election is in recognition of her transformational discoveries revealing that tissue-resident macrophages are an independent cell lineage that arises and is maintained independently of adult hematopoiesis, and that these cells have unique functional attributes that promote tissue integrity and tissue repair, responses to infection, and shape tumor outcomes.
Jun 20, 2023
Dr. Chen received the award for his contributions to identifying the drivers of COVID-19 disease severity and mortality in the Mount Sinai COVID-19 BioBank. Dr. Chen's discoveries may guide the development of tailored immunotherapy strategies to halt disease progression in COVID19 and other inflammatory diseases.
May 17, 2023
Dr. Patel received the award for his excellence as a research scientist, having published over 27 peer-reviewed articles, five of which he was the first author. His research focused on atypical immune response to viral infections, specifically investigating the role of innate immune cells in antiviral defense. Dr. Patel's discoveries could inform the development of life-saving antiviral therapies.
May 01, 2023
This grant will support Dr. Brody’s research on preventing lymphoma relapse after T-cell-based immunotherapies which has the potential to yield long-lasting remissions for lymphoma patients.
May 01, 2023
Diego Chowell, PhD received the MRA Young Investigator Award to study "Dissecting the dynamic immune ecosystem during melanoma evolution" and Poulikos Poulikakos, PhD received the MRA Pilot Award to study “A drug-binding assay platform to optimize therapies for Ras-mut melanomas”.
Apr 20, 2023
Dr. Bogunovic received this award in recognition for his outstanding contributions to the field of cytokine biology and his remarkable international reputation as an immunologist and geneticist with a focus on inborn disorders of the immune system, especially concerning the JAK/STAT pathway.
Mar 29, 2023
Amir Horowitz, PhD, with Co-PIs Matthew Galsky, MD and John Sfakianos, MD, seek to establish proof-of-concept for a novel immunotherapy combination of two drugs, durvalumab and monalizumab, that may delay or prevent the need for a radical cystectomy in patients with BCG-unresponsive, non-muscle invasive bladder cancer.
Mar 24, 2023
Dr. Lafaille received funding for her research project titled "Cross-regulation of STAT signaling pathways in lung pathology of experimental HIES". She is also the award recipient for the Mindich Child Health and Development pilot program, with Co-PI Dr. Goran Bajic, for the project titled "Structure-function studies of Ara h 2 specific antibodies isolated from highly sensitized children with peanut allergy".
Feb 23, 2023
Research from the Swirski lab is among the first to show that skipping meals triggers a response in the brain that negatively affects immune cells. The study was published in Immunity, and could lead to a better understanding of how chronic fasting may affect the body long-term.
Feb 22, 2023
Research in the Bogunovic lab has revealed which parts in the immune system go awry and contribute to autoimmune diseases in individuals with Down syndrome. The findings were published in Nature and add to the team’s previous work showing that people with Down syndrome have less frequent by more severe viral infections.
Feb 08, 2023
A phase II clinical trial led by Brian Kim, MD suggests that patients experiencing moderate-to-severe itching, associated with notalgia paresthetica, could potentially get relief with oral difelikefalin. The study was published in the New England Journal of Medicine and offers hope for patients with this common, yet underdiagnosed condition which is characterized by a persistent itch in the upper back.
Feb 01, 2023
This grant will fund efforts to identify potential new strategies for improving treatment of NMIBC with the only FDA approved first- line treatment option, Bacillus Calmette-Guérin as a single therapy or in combination with other immunotherapies.
Oct 24, 2022
Dr. Burakoff received the award for developing small molecule therapeutic inhibitors targeting HPK1 to regulate the immune response against cancer. This technology entered phase 1 clinical trials in spring 2022.
Oct 04, 2022
One of the largest single-center COVID-19 cohort studies, to date, revealed that maintenance of reparative lung macrophages while reducing accumulation of circulating myeloid cells may be a viable therapeutic strategy for the treatment of SARS-CoV-2 and other inflammatory lung diseases.
Sep 12, 2022
Research published in Cancer Cell reported important discoveries about the mechanism by which bladder cancer cells foil attacks from the immune system and identified potential ways to make immunotherapy more effective against bladder cancer.
Sep 01, 2022
In a report published in Blood Advances, researchers showed that multiple myeloma patients who relapse after initial bispecific antibodies therapy can benefit from a second bispecific antibody or CAR-T cell therapy.
Jun 21, 2022
The American Association of Indian Scientists in Cancer Research (AAISCR) presented the 2022 Lifetime Achievement award to Dr. Bhardwaj for advancing the understanding of how to fight cancer by using innate immune cells to reverse immunosuppression in tumor microenvironments.
Jun 14, 2022
In a study published in Nature Biotechnology, Mount Sinai researchers reported the development of a rapid blood assay that measures the magnitude and duration of a person's immunity to SARS-CoV-2.
Mar 28, 2022
Bishuang Cai, PhD is the recipient of the award for her project, "A novel mechanism of MerTK cleavage in atherosclerosis"; the award supports highly promising healthcare and academic professionals to explore innovative questions or pilot studies that will provide preliminary data and training necessary to assure the applicant's future success as a research scientist.
Mar 28, 2022
Hugh Sampson, MD was awarded by the American Academy of Allergy Asthma & Immunology for a lifetime of service as an allergy/immunology mentor for students, residents, fellow-in-training and faculty.
Mar 24, 2022
Etienne Humblin is one of the winners of the travel grant for his abstract, "Discovering novel mechanisms by which CD28 signaling influences antigen-specific PD-1+ CD8 T cells".
Jan 31, 2022
Dr. Bishuang Cai is the recipient of the award which supports talented biomedical scientists in their academic research careers.
Jan 25, 2022
In collaboration with Mass Gen and U Toronto, Sacha Gnjatic, PhD received the subaward for investigating biomarkers to accurately predict the onset and prognosis of Crohn's disease.
Jan 19, 2022
Results from first-of-its-kind Mount Sinai study show that immunotherapy before liver cancer surgery can kill tumor, and likely residual cancer cells.
Dec 01, 2021
Diego Chowell, PhD is a Sinsheimer Scholar Award recipient for his research project, "Learning the language of T cell epitope recognition: Implications for vaccine design against cancer and viruses".
Nov 16, 2021
Clarivate recognized pioneers from across the globe who demonstrated significant influence in their chosen field(s) through the publication of multiple highly cited papers that rank in the top 1% by citations for field and year in the Web of ScienceTM.
Nov 15, 2021
Dr. Miriam Merad discusses the role of myeloid cells in shaping immune responses to tumor cells at the Society for Immunotherapy of Cancer's (SITC) 2021 annual meeting.
Oct 18, 2021
Dr. Samir Parekh was recently interviewed on the need for COVID-19 booster vaccination in multiple myeloma patients.
Oct 05, 2021
Judy Cho, MD, is the 2021 Sherman Prize recipient for advancing our understanding of the underlying causes of IBD and paving the way for personalized treatment approaches.
Aug 05, 2021
Robert Samstein, MD, PhD, received the award for his project “Unraveling Immune Surveillance in Microsatellite-Unstable Cancers”
Jul 28, 2021
Lucas Ferrari de Andrade, PhD, received a Clinic and Laboratory Integration Program (CLIP) grant from CRI to study “A new NK cell-based immunotherapy for acute myeloid leukemia”
Jul 13, 2021
Miriam Saffern, PhD student at the Icahn School of Medicine at Mount Sinai, is one of the winners of the 2021 Lasker Essay Contest. Her winning essay is “My Mother is a Layperson”.
Jun 16, 2021
Scientists discovered that immune cells that normally repair tissues in the body can be fooled by tumors when cancer starts forming in the lungs and instead help the tumor become invasive.
Jun 16, 2021
Miriam Merad, MD, PhD, talks about the promise of immunotherapy and the importance of paying it forward.
