Precision Immunology Institute

About Us

The Precision Immunology Institute at Icahn School of Medicine at Mount Sinai (PrIISM) fosters interdisciplinary, translational research in immunology, immunologic diseases, and transplantation. Mount Sinai scientists and clinicians have gained international recognition in areas such as primary immunodeficiency, mucosal immunity, inflammatory bowel disease, allergic diseases, and liver transplantation. Today, Mount Sinai programs in the study and treatment of asthma, arthritis, multiple sclerosis, diabetes, hepatitis C, HIV, and organ transplantation are stronger than ever and still growing.

The Institute builds upon a strong foundation of basic research within the Immunobiology Center and an equally solid program of clinical research and practice in the divisions of clinical immunology within the Departments of Medicine and Pediatrics.

Recently named as Director of the Mount Sinai Immunology Institute, Meriam Merad, MD, PhD, is an internationally known cancer researcher. In 2010 Dr. Merad became the program leader of the Cancer immunology immunotherapy group at The Tisch Cancer Institute and the director of the Human Immunomonitoring center, which goal is to identify novel immune biomarkers of disease and response to therapy in patients with cancer and allergic disease Dr. Merad also serves as the Associate Director for the MD PhD program at Mount Sinai Medical School.

Dr. Merad’s laboratory studies the mechanisms that regulate the development and function of innate myeloid cells including dendritic cells and macrophages. One of the major goals of her laboratory is to identify the contribution of these cells to the development and progression of tumor cells. Dr. Merad’s hypothesis suggests that tumors do not consist of a homogenous mass of genetically altered cells but rather include a large amount of innate myeloid cells that significantly contribute to tumor development. Dr. Merad established that tumor infiltrating dendritic cells could be targeted in vivo to promote the induction of tumor specific immunity. Currently, she is examining the contribution of tumor infiltrating macrophages to tumor progression and response to conventional and targeted therapies.

In 2013, Dr. Merad was the primary organizer of the prestigious Keystone conference on dendritic cell biology and was elected to the “American Society of Clinical Investigation”. She has authored more than 100 primary papers and review articles in high profile journals and obtained extensive NIH funding for her studies on dendritic cells and macrophage biology in mice and humans.

Miriam Merad, MD, PhD, Director, Precision Immunology Institute at Icahn School of Medicine at Mount Sinai (PrIISM):  Macrophage and Dendritic cell biology, Innate immunity, Vaccine immunology, Microbial immunity, Cancer immunology and immunotherapy

Konstantina Alexandropoulos, PhD: Autoimmunity, Autoimmune Hepatitis, T cell tolerance, T cell trafficking, Mucosal Immunology, Transplantation, Signal Transduction

Cecilia Berin, PhD: Allergy, Mucosal Immunology

Nina Bhardwaj, MD, PhD: Antigen Presentation, Autoimmunity, Innate Immunity, Tumor Immunology, Vaccine Immunology

Joshua Brody, MD: Tumor Immunology, B-cell Lymphoma, Vaccine Immunology, Signal Transduction, Transplantation

Brian Brown, PhD: Antigen Presentation, Autoimmunity, Functional Genomics, Innate Immunity, Diabetes, Immune Tolerance, Molecular Regulation, Myeloid cell regulation, RNA interference, Systems Biology, Tolerogenic Vaccines

Steven Burakoff, MD: Tumor Immunology, negative regulation of T cell activation, signal transduction, cancer drug discovery, autoimmunity, HIV1 Nef

Paula Busse, MD: Hereditary Angioedema

Minji Byun, PhD: Rare Inflammatory Diseases, Human Genetics, Primary Immunodeficiencies 

Andrea Cerutti, MD: B Cells, Immunoglobulin Genes, Lymphocytes, Mucosal Immunology

Benjamin Chen, MD, PhD: HIV and AIDS, infectious disease, pathogenesis, vaccine immunology

Shu-Hsia Chen, PhD: Tumor Immunology, Transplantation, Inflammation and Tolerance

Hearn Jay Cho, MD, PhD: Multiple Myeloma

Judy H. Cho, MD: IBD, Functional Genomics, Lipid Mediators, Systems Biology

Jose C. Clemente Litran, PhD: Microbiome, Bioinformatics, IBD

Jean-Frederic Columbel, MD: IBD

Charlotte Cunningham-Rundles, MD, PhD: Primary Immune Deficiency, Autoimmunity, Immunogenetics

Terry Davies, MD: Thyroid autoimmunity, Graves' disease, Hashimoto's thyroiditis, TSH receptor antibodies, TSH receptor signal transduction, TSH receptor antigen processing, genetics of autoimmune thyroid disease.

Jeremiah Faith, PhD: Host/Microbe Interactions, IBD, Systems Biology

James Ferrara, MD: BMT, GVHD, Innate Immunology

Glaucio Furtado, PhD: Autoimmunity, Cell Trafficking, Inflammatory Bowel Disease (IBD), Innate Immunity, Mucosal Immunology

Sacha Gnjatic, PhD: Antigen Presentation, Immunomodulation, Immunotherapy, Tumor Immunology, Vaccine Immunology

Percio Gulko, MD: Rodent models of autoimmune arthritis, Synovial fibroblast biology, Regulation of arthritis severity and joint damage, Rheumatoid arthritis, Psoriatic arthritis, Genetics and Genomics, Drug discovery

Emma Guttman, MD: Inflammatory Skin Diseases, Skin Immunology, Atopic Dermatitis, Contact Hypersensitivity, Allergens, T-cells, Dendritic cells

Peter Heeger, MD: Innate Immunity, Transplantation

Dirk Homann, MD: Specific T cell immunity in autoimmune disease (Type 1 diabetes) and infectious disease (acute and chronic viral infections)

Ephraim Kenigsberg, PhD: Trancriptional Regulation of Inflammation, Single-Cell Genomics, Population Genomics

Uri Laserson, PhD: Immunoglobin Genes, Immunology, T Cells

Xiu-min Li, MD: Food allergy, Immunopathic Mechanisms

Sergio Lira, MD, PhD: Autoimmunity, Cell Trafficking, Mucosal Immunology, Inflammatory Bowel Disease, Tumor immunology

Madhan Masilamani, PhD: Food Allergy, Phytochemistry and Immunoregulation

Saurabh Mehandru, MD: Dendritic Cells, Mucosal Immunology

Thomas Moran, PhD: Therapeutic Monoclonal antibody production, Immunology of Pregnancy, Cell Trafficking, Infectious Disease, Innate Immunity, Mucosal Immunology, Vaccine Immunology

Barbara Murphy, MD: Transplant Immunology

Jordi Ochando, PhD: Transplant Immunology and Immunological Tolerance

Towfique Raj, PhD: Neuroimmunology, Systems Immunology, Computational Biology, Genetics and Genomics, Neurodegenerative Diseases

Scott Russo, PhD: Depression, Inflammation, Blood Brain Barrier

Hugh Sampson, MD: Food Allergy, Immunotherapy, Tolerance Induction

Stuart Sealfon, MD: Systems Biology, Computational Immunology, Bioinformatics

Adrian Ting, PhD: Cell Death, Signal Transduction; Inflammation

Hideki Ueno, MD, PhD: Human Immunology, Adaptive Immunity, T cells, Autoimmunity, B Cells, Dendritic Cells, Infectious Disease, Vaccine studies

Huabao Xiong, MD, PhD: Inflammatory bowel diseases (IBD), Innate immunity, Mucosal Immunology, Signal transduction

Lan Zhou, MD, PhD: Neuroinflammation

Karen Zier, PhD: Tumor Immunology


The Precision Immunology Institute at Icahn School of Medicine at Mount Sinai (PrIISM) would not be what it is today without the vision and inspiration of it’s founder, Lloyd F. Mayer, MD. Lloyd was a giant in the field of Gastroenterology and Clinical Immunology and a world-renowned expert in Inflammatory Bowel Disease and Crohn’s Disease.

Lloyd was Mount Sinai. He graduated from the medical school, completed his fellowship here and was a leader in the Department of Medicine for over three decades. To say that Lloyd was a gifted physician and researcher doesn’t really begin to describe his contributions to Mount Sinai, to his patients and to science as a whole. There are countless gastroenterologists and immunologists trained by Lloyd who bear testament to his immense legacy of education and mentorship. He received nearly every award a physician-scientist could receive at this institution and as a scientist with an international reputation.

But for those of us who knew Lloyd well, the biographies, the awards and the accolades really don’t even begin to describe who he really was. Lloyd was a true friend, loyal to the core. He was lovingly irreverent, brilliant and wonderfully fun to be around. He was a mentor to so many newly minted physicians and he instilled a love of science and a love of innovation and discovery.

We miss him every day and are inspired by him to continue to learn, to innovate and to enjoy the pursuit of knowledge.


The Precision Immunology Institute at Icahn School of Medicine at Mount Sinai (PrIISM) seeks outstanding scientists to develop rigorous independent research programs in basic or translational T cell immunology. Applicants whose programs aim to develop novel T cell-based strategies for therapy of cancer, inflammatory bowel disease, or autoimmunity, are encouraged to apply.

The Precision Immunology Institute at Icahn School of Medicine at Mount Sinai (PrIISM) is a diverse interactive group interested in basic and translational immunology and mechanisms of immune-mediated diseases. Applicants may have an MD, PhD or MD/PhD degrees and may be appointed at the Assistant, Associate or Full Professor levels, at Icahn School of Medicine at Mount Sinai with a generous start-up package.

Applicants should submit a CV, research plan and the names of three references to Precision Immunology Institute at Icahn School of Medicine at Mount Sinai (PrIISM) Faculty Search Committee, email: