The Administrative Core, under the direction of Mary Sano, PhD, Samuel Gandy, MD, PhD and Patrick R. Hof, MD maximizes the productivity of the projects and cores of the ADRC through the integration of scientific, fiscal, and clerical activities. To set the research directions of the ADRC, the Administrative Core provides mechanisms for the submission of pilot projects and facilitates support for AD research that is not directly funded by the ADRC by making the Center's resources available to those studies. The Administrative Core facilitates interactions among cores and projects, as well among other ADCs, and AD based research and service groups. The core has also collaborated in several projects submitted to NACC with other ADCs. The Administrative Core aims to foster the growth of new research and new researchers. The Administrative core is committed to developing clinical and basic science investigators by providing training, mentoring opportunities and resources in the way of pilot funding to new researchers.
The Clinical Core, under the leadership of Mary Sano, PhD, and Hillel Grossman, MD performs comprehensive clinical and neuropsychological patient evaluations, coordinates data transfer to the Data Management Core, and conducts longitudinal follow up of Alzheimer's disease and non-demented individuals. The Clinical Core coordinates recruitment of subjects for the Mount Sinai ADRC, the Alzheimer's Disease Cooperative Study (ADCS), and other National Institute of Health-funded studies, as well as non-funded pilot studies. This core provides training to a wide range of individuals to assist in the collection of data, and it approaches all participants for possible participation in the autopsy program. In its ongoing efforts to serve a diverse population, the Clinical Core maintains several Satellite Diagnostic and Treatment Clinics in Queens, the Bronx, and Westchester.
Data Management Core
The Data Management Core, headed by Xiaodong Luo, PhD, receives, stores, catalogues, tracks and integrates data generated by the Cores and Projects in the ADRC and provides expert advice for the statistical analysis of data components or integrations. A highly secure data management infrastructure has been developed in the form of a data warehouse system within the Department of Psychiatry with management of data derived from this ADRC, a Program Project Grant in Early AD, and a recently awarded Conte Center for the Neuroscience of Mental Disorders (CCNMD) at its core. The Core provides seamless integration of data acquired by ADRC cores and projects with NACC data sets and can provide turn-key generation of data sets to accommodate NACC data calls. The Data Management Core integrates data resulting from the Clinical Core and Neuropathology Core, with data emerging from the specific projects into a centralized resource that enhances cross-fertilization of projects while at the same time providing for ready access to all relevant data to all investigators.
Education and Information Transfer Core
The Education and Information Transfer Core (EITC), directed by Margaret Sewell, PhD and Judith Neugroschl, MD, provides educational programming regarding Alzheimer's disease diagnosis, treatment, management, and research advances and training, to a diverse lay and professional audience. This is accomplished through lecture series for physicians and other healthcare professionals in training as well as community lectures, workshops, the Memory Enhancement Program, and CME programs. Outreach efforts are also accomplished, in both English and Spanish, through the ADRC newsletter, joint publications with NYCARE (the collaboration of the Education Cores of New York City's Alzheimer's Disease Centers and the New York City chapter of the Alzheimer's Association) for the Alzheimer's Association Newsletter, brochures, lectures, workshops, conferences, and health fairs. The ongoing collaboration with the Mount Sinai's Alzheimer's Disease Assistance Center further allows the Core to provide educational programming and outreach specifically targeted to the large Hispanic community the Core serves.
The Neuropathology Core, directed by Dushyant Purohit, MD, and Vahram Haroutunian, PhD, serves to obtain autopsy-derived brain specimens from individuals who have been evaluated and followed longitudinally by the Clinical Core. The Core strives to obtain the brain specimens with the shortest postmortem interval and for the entire specimen collection the mean postmortem interval is less than six hours. The specimens are dissected and preserved in a manner that maximizes their utility for the needs of both the proposed experiments within the Center as well as other AD and aging-related research projects. A detailed neuropathologic work-up is carried out to establish a neuropathologic diagnosis as well as to document the extent and distribution of relevant neuropathologic lesions. These data are entered into an extensive database, which can be integrated into the clinical database for the purpose of cliniconeuropathologic correlative investigations. The tissues collected have been used extensively in a wide range of studies. They are requested both by researchers within the ADRC, the greater Mount Sinai research community, and by many other researchers nationally and internationally.
To schedule an evaluation, please call 212-241-1844.
Dr. Mary Sano
One Gustave L. Levy Place
New York, NY 10029
Tel: 718-584-9000, ext. 5199
James J. Peters VA Medical Center
130 West Kingsbridge Road
Bronx, NY 10468