At the Icahn Institute for Genomics and Multiscale Biology, we use a multifaceted approach that combines epidemiology, genomics, and multiscale biology to study allergies and asthma.
Asthma, food allergy, allergic rhinitis (hayfever), and atopic dermatitis (eczema) are common in both children and adults. On an average day in the United States, asthma causes: 44,000 asthma attacks, 36,000 kids to miss school, 27,000 adults to miss work, and 4,700 people to visit the emergency room. And, the rate of asthma and allergies continues to grow. Asthma and allergic disorders can also affect genetically susceptible individuals exposed to particular environmental conditions.
Our goal is to better understand and identify risk factors, mechanisms, and potential therapies for asthma and allergies. This work is led by the Bunyavanich laboratory.
Our Published Research
Supinda Bunyavanich, MD, and colleagues, have been published in a number of national and international journals. Featured below is some of their recent work.
“Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.” Read the full study
The Journal of Allergy and Clinical Immunology
“Systems Biology of Asthma and Allergic Disease: A Multiscale Approach.” Read the full manuscript.
“Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity.” Read the full study.
“Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children.” Read the full study
BMC Medical Genomics
“Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis.” Read the full study
Clinical and Experimental Allergy
“Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma.” Read the full study
“Unravelling gene-by-environment effects in asthma and allergy: the glutathione pathway as an early success story.” Read the full manuscript.
"A Twin Study of Early-Childhood Asthma in Puerto Ricans.” Read the full study
Clinical and Molecular Allergy
“Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma.” Read the full study
Pediatric Allergy & Immunology
“A meta-analysis of Th2 pathway genetic variants and risk for allergic rhinitis.” Read the full study.