Alzheimer's Disease

Alzheimer's disease (AD) research at The Friedman Brain Institute integrates several basic and translational dementia efforts while also extending investigations into the molecular basis of the disease. Among these efforts are:

Advances in Research

The Administrative Base and Central Laboratory for Cure Alzheimer's Fund Stem Cell Consortium CAFSCC is an international effort focusing on the use of induced pluripotent stem cell (iPSC) technology in order to understand the molecular basis for Alzheimer's disease.  Physician-scientists, stem cell experts, neurogeneticists, and neurophysiologists from the Icahn School of Medicine at Mount Sinai, Harvard Medical School, Massachusetts General Hospital, The Rockefeller University, The New York Stem Cell Foundation, and Hadassah University collaborate on modeling of pathophysiological neuronal and neuronal-glial mixed cell phenomenology related to Alzheimer's disease.  For example, in a current project, iPSC-derived neurons and mixed cultures taken from a sibship (a group of children of the same parents) with a pathogenic mutation in presenilin 2 are being used to test a new gamma secretase modulator to determine whether their family would be eligible to enroll in a clinical trial of this new drug.

Other research efforts are underway to identify new risk genes for Alzheimer's disease and other dementias (frontotemporal dementia, for example), in studying the biology of amyloid-related neuropathology, and in investigating common genetic links between Alzheimer's disease and metabolic disorders such as diabetes.

Investigators involved: Dongming Cai, Dara L. Dickstein, Michelle Ehrlich, Samuel E. Gandy, Patrick R. Hof, Giulio M. Pasinetti, Nikolaos K. Robakis

Advances in Patient Care

Mount Sinai has long been a leader in developing new treatments for Alzheimer's disease and other memory-related disorders. Learn more

Clinical research remains a major focus of our efforts, led through the Alzheimer's Disease Research Center (ADRC), one of the first ADRC's established and now in its 39th year of funding. Learn more

Contact Us

Mary Sano, PhD
Phone: 212-241-8329
Fax: 212-996-0987
Send e-mail

Alzheimer's Disease Research Center
One Gustave L. Levy Place
Box 1230
New York, NY 10029


Phone: 718-584-9000 ext. 5199
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James J. Peters VA Medical Center
130 West Kingsbridge Road

Schedule an Appointment

Phone: 212-241-1844