John F Crary

John F Crary, MD, PhD

  • PROFESSOR | Pathology, Molecular and Cell Based Medicine
  • PROFESSOR | Neuroscience


Anatomic Pathology and Clinical Pathology

Research Topics:

Aging, Alzheimer's Disease, Amyotrophic Lateral Sclerosis, Axonal Growth and Degeneration, Biomechanics/Bioengineering, Brain, Cancer, Cell Biology, Cytoskeleton, Drosophila, Genetics, Microtubules, Molecular Biology, Neuro-degeneration/protection, Neurobiology, Parkinson's Disease, Pathology, RNA, RNA Splicing & Processing, RNA Transport & Localization

Dr. Crary is a pathologist who went to Brown University and majored in Neuroscience.  This is where he fell in love with brain research, conducting a project looking at NMDA mediated pain processing in the trigeminal system. He received his MD-PhD from SUNY Downstate Medical Center.  It is at this time that he developed a strong interest in the neuropathology of Alzheimer's disease, particularly neurofibrillary type degeneration.  His thesis research highlighted a unique pattern of neurofibrillary degeneration in the limbic system that is associated with an atypical protein kinase C isoform.

Dr. Crary did his residency and fellowship training in Neuropathology at Columbia University Medical Center and stayed on as an Assistant Professor.  There, he conducted seminal work that led to the description of primary age-related tauopathy (PART).  In 2014, Dr. Crary established a new neuropathology laboratory at Mount Sinai to continue this work and expand it to other neurodegenerative tauopathies, including chronic traumatic encephalopathy and progressive supranuclear palsy.  Dr. Crary has numerous federal and foundation grants to study these diseases.  Dr. Crary is a member of the editorial board of Acta Neuropathologica and is a frequent contributor to the Tau Consortium.


He runs the Crary Laboratory and the Neuropathology Brain Bank and Research CoRE at the Icahn School of Medicine at Mount Sinai.


Multi-Disciplinary Training Area

Neuroscience [NEU]


MD, SUNY Downstate Health Sciences University - College of Medicine

Residency, Pathology, Columbia University Irving Medical Center

Fellowship, Neuropathology, Columbia University Irving Medical Center

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