Samuel E Gandy

Samuel E Gandy, MD, PhD

  • PROFESSOR | Neurology
  • PROFESSOR | Psychiatry


Neurology, Alzheimer's Disease

Research Topics:

Alzheimer's Disease, Biochemistry, Biomedical Sciences, Biophysics, Brain, Brain Imaging, Cell Biology, Cognitive Neurology, Cognitive Neuroscience, Drug Design and Discovery, Genetics, Genomics, Hippocampus, Hormones, IGF-1 Receptor, Immunology, Induced pluripotent stem cells, Inflammation, Interferon, Intracellular Transport, Lipid Signaling, Lysosomes/endosome, Macrophage, Mass Spectrometry, Memory, Metabolism, Microglia, Neuro-degeneration/protection, Neurobiology, Neurology, Neuronal Regeneration, Neuroscience, Neurotoxicology, Neurotransmitters, Personalized Medicine, Pharmacogenomics, Pharmacology, Phosphorylation, Positron Emission Tomography, Prefrontal Cortex, Proteases, Protein Complexes, Protein Degradation, Protein Folding, Protein Kinases, Protein Phosphatases, Protein Structure/Function, Protein Trafficking & Sorting, Proteomics, Psychiatry, Receptors, Regeneration, Stem Cells, Synapses, Synaptic Plasticity, Synaptogenesis, Systems Biology, T Cells, Trafficking, Viruses and Virology

Sam Gandy, MD, PhD, is Mount Sinai Professor of Alzheimer's Disease Research, Professor of Neurology and Psychiatry, Associate Director of the Mount Sinai Alzheimer's Disease Research Center in New York City, and Chairman Emeritus of the National Medical and Scientific Advisory Council of the Alzheimer's Association. Dr. Gandy is an international expert in the metabolism of the sticky substance called amyloid that clogs the brain in patients with Alzheimer's. In 1989, Gandy and his team discovered the first drugs that could lower formation of amyloid. Dr. Gandy has written more than 250 original papers, chapters, and reviews on this topic. Dr. Gandy has received continuous NIH funding for his research on amyloid metabolism since 1986.

Dr. Gandy is studying new methods for using blood and brain imaging biomarkers to diagnose chronic traumatic encephalopathy (CTE) during life in athletes retired from collision sports and in former warfighters exposed to improvised explosive device blast injuries on the battlefield.  Dr. Gandy is also testing new classes of drugs aimed at relieving brain trauma-related neuropsychiatric syndromes such as post-traumatic stress disorder (PTSD).

Dr. Gandy is a member of the Faculty of 1000 Biology and serves as a consulting editor for The Journal of Clinical Investigation.  He also serves on the editorial advisory boards for the journals Public Library of Science-Medicine (PLoSM), Neurodegenerative Diseases, and Current Alzheimer Research.  He is associate editor of the journals Molecular Neurodegeneration and Alzheimer Disease and Associated Disorders. From 1996-2006, Dr Gandy was Director of the Cold Spring Harbor Laboratories/Wellcome Trust Annual Summer Course on the Neurobiology of Human Neurological Disorders. In 2000, he became chief organizer for the Cold Spring Harbor Laboratories Bi-Annual Winter Biotechnology Conference on Therapeutic Opportunities in Neurodegenerative Diseases and continues in that role until 2010.

Dr. Gandy has appeared numerous times on television and in print, including:

Dr. Gandy was featured with other prominent research scientists as GQ's "Rockstars of Science". View the PDF. In addition, Dr. Gandy has spoken before Congress on several occasions.

Dr. Gandy received both his MD and PhD at the Medical University of South Carolina. He completed an internship in internal medicine at the Columbia University College of Physicians & Surgeons and a residency in neurology at Cornell University Medical College. Dr. Gandy completed postdoctoral training at The Rockefeller University, where, in 1991, he was appointed assistant professor in the laboratory of Paul Greengard, 2000 Laureate of the Nobel Prize in Physiology or Medicine. From 1992-1997, Gandy was Associate Professor of Neurology and Neuroscience at Cornell University Medical College. From 1997-2001, he was Professor of Psychiatry and of Cell Biology at New York University and The Nathan S. Kline Institute for Psychiatric Research. From 2001-2007, heserved as Paul C. Brucker, M.D., Professor of Neuroscience at Jefferson Medical College and Founding Director of the Farber Institute for Neurosciences. In 2007, he assumed his current post as Mount Sinai Professor of Alzheimer's Disease Research at the Icahn School of Medicine at Mount Sinai.   Dr. Gandy offers telemedicine appointments when appropriate.  Please call his office to schedule a video visit.   Dr. Gandy is registered to provide telehealth services in Florida.

Clinical Focus

  • Alzheimer's Disease
  • Aphasia
  • Apraxia
  • Cognitive Impairment (Post Head Injury)
  • Cognitive or Memory Impairment / Dementia
  • Confused Memory
  • Confusion (Post Head Injury)
  • Delirium
  • Dementia
  • Frontal Lobe Dementia

Multi-Disciplinary Training Areas

Genetics and Genomic Sciences [GGS], Neuroscience [NEU]


MD, Medical University of South Carolina

MD, PhD, Medical University of South Carolina

Internship, Internal Medicine, Columbia University College of Physicians & Surgeons

Residency, Neurology, New York Hospital Cornell University Med Ctr

Physicians who provide services at hospitals and facilities in the Mount Sinai Health System might not participate in the same health plans as those Mount Sinai hospitals and facilities (even if the physicians are employed or contracted by those hospitals or facilities).

Information regarding insurance participation and billing by this physician may be found on this page, and can also be obtained by contacting this provider directly. Because physicians insurance participation can change, the insurance information on this page may not always be up-to-date. Please contact this physician directly to obtain the most up-to-date insurance information.

Insurance and health plan networks that the various Mount Sinai Health System hospitals and facilities participate in can be found on the Mount Sinai Health System website.