Human Immune Monitoring Center

• R01 Harnessing Csf-2 compartmentalized role on tissue resident phagocytes to uncouple anti-tumoral from pathological immunity induced by checkpoint inhibitors.
  PI: Miriam Merad
  
  
• U24 High-dimensional immune monitoring of nci-supported immunotherapy trials.
  PI: Sacha Gnjatic
  
  
• U24 Novel tools to maximize profiling of tissue and antigen specific immune dysregulation in allergy and inflammatory bowel disease.
  PI: Miriam Merad
  
  
• P30 The Tisch Cancer Institute - Cancer Center Support Grant
  PI: Ramon Parsons
• R01 Evaluation of HCC Response to Systemic Therapy with Quantitative MRI
  PI: Bachir Taouli
  
  
• Characterization of Prostate Cancer Aggressiveness with Advanced Multiparametric Magnetic Resonance Imaging
  Prostate Cancer Foundation
  PI: Bachir Taouli
  
  
• MRI-Based Surrogate Imaging Markers of Transcriptome Subclasses and Signatures in Hepatocellular Carcinoma
  Type: Foundation (RSNA)
  PI: Bachir Taouli
  
  
• R01 Clinical Targeting of Prostate Cancer Dormancy
  PI: Julio A. Aguirre-Ghiso and Dr. Samuel Sidi
  
  
• P01 Personalized Immunotherapy of Patients with Ovarian Cancer
  PI: David Spriggs
  
  
• R21 Biological Effects of Systematic Light Exposure for Cancer-Related Fatigue
  PI: William Redd
  
  
• R01 Systematic Light Exposure to Treat Cancer-Related Fatigue in Breast Cancer Patients
  PI: William Redd

• R21 Inflammatory and Neurocircuit Mechanisms of Anhedonia in Human Depression
  PI: PI: James Murrough
  
  
• R01 The Neuroimmunology of Anhedonia
  PI: Vilma Gabbay
  
  
• R01 The Role of Peripheral Myeloid Cells in Alzheimer Disease (AD)
  PI: Towfique Raj
  
  
• R37 Histone Deacetylation in Oligodendrocyte Differentiation
  PI: Patrizia Casaccia
  
  
• R01 Effectiveness of Peripheral Treatment of Susceptive Mice with IL-6 Antibodies.
  PI: Scott J Russo
  
  
• P50 Resistance to Social Defeat Through Promotion of Psychological Resiliency
  PI: Scott J Russo
  
  
• R01 Neuroinflammation and PVS Deficits in Adolescents
  PI: Vilma Gabbay
  
  
• U01 Neurocircuitry of Impaired Insight in Addiction
  PI: Bety Casey
  
  
• R01 Event-Related Potentials to Longitudinally Track in Cocaine Addicted Individuals
  PI: Rita Z Goldstein

• P01 Stress and Atherosclerotic Plaque Macrophages – a Systems Biology Approach
  PI: Zahi Zayad
  
  
• Delineating the Triggers and Impact of Pathologic Cardiac Remodeling Following Premature Birth
  The American Heart Association
  PI: Alan Groves
  
  
• K23 Role of Alternatively Spliced Tissue Factor in Atherosclerosis
  PI: Chiara Giannarelli
  
  
• R03 Dissecting the Cellular and Molecular Immune Interactions in Atherosclerosis
  PI: Chiara Giannarelli
  
  
• R21 Network-Driven Drug Repurposing Approaches to Treat Coronary Artery Disease
  PI: Chiara Giannarelli
  
  
• UH2 Single-Cell-Driven Drug Repositioning to Target Inflammation in Atherosclerosis
  PI: Chiara Giannarelli

• Characterizing the Single Cell Expression of the IL23 Receptor (IL23R) in Crohn's Disease (CD) Patients Utilizing CyTOF Technology
  Department of Medicine Junior Faculty Translational Collaborative Research Initiative Grant
  PI: Ryan Ungaro
  
  
• U24 Novel tools to maximize profiling of tissue and antigen specific immune dysregulation in allergy and inflammatory bowel disease.
  PI: Miriam Merad

The HIMC serves as a central immune monitoring center for several large multicenter consortia.

• U24 CIMAC: High-Dimensional Immune Monitoring of Nci-Supported Immunotherapy Trials
  PI: Sacha Gnjatic (Mount Sinai)
  
  
• U19 HIPC: Human Anti-Viral Immune Responses in Tissues and Circulation
  PI: Donna Farber (Columbia)
  
  
• U19 HIPC: Dengue Human Immunology Project Consortium (DHIPC)
  PI: Anna Sesma (Mount Sinai) and Eva Harris (UC Berkeley)
  
  
• Mount Sinai Children’s Health Exposure Analysis Resource (CHEAR) Network Laboratory Hub and Mount Sinai CHEAR Network Laboratory Hub Targeted Analysis Resource
  PI: Robert Right
  
  
• U01 Mount Sinai School of Medicine Inflammatory Bowel Disease Genetics Research Center
  PI: Judy Cho 
  
  
• U10 Dry Eye Evaluation and Management (DREAM) Study
  ABCD-USA: NYC Research Project
  PI: Penny Asbell

• U24 Novel tools to maximize profiling of tissue and antigen specific immune dysregulation in allergy and inflammatory bowel disease.
  PI: Miriam Merad
  
  
• S10 High End Instrumentation Grant - HELIOS MASS CYTOMETER
  PI: Adeb Rahman

• R01 Dextran Sulfate, Beta Cell Preservation and Immune Regulation in Type 1 Diabetes
  PI: Rita Z Goldstein
  
  
• U24 Novel tools to maximize profiling of tissue and antigen specific immune dysregulation in allergy and inflammatory bowel disease.PI: Miriam Merad

In addition to academic studies, the HIMC has extensive experience with supporting immune monitoring studies sponsored by several industry collaborators including Celgene, BMS, Janssen, Pfizer, Takeda, Immune Design, Gradalis, TapImmune, AstraZeneca, Genetec, and DynaVax.