Assays and Technology

The HIMC operates a cutting-edge facility spanning 7,500 square feet in the ISMMS Hess Center for Science and Medicine (5th and 6th floors) and Hudson Research Center (9th floor). We combine advanced scientific and technical expertise with state-of-the-art technology to deliver innovative immunological assays while emphasizing the optimization and standardization of protocols to ensure data quality and reproducibility.

HIMC manages a comprehensive range of platforms, from biological sample processing and storage using our real-time lab specimen inventory system, to immune assays conducted by our skilled technical team. Our integrated immune monitoring services follow strict SOPs and QA/QC standards, supporting a variety of human diseases and translational studies.

HIMC Technology Platforms:

Biospecimen (eg. Blood, bone marrow) Processing and Management; human
High-dimensional Cytokine/protein biomarker analysis, multi species
Phenotypic and Functional Immunophenotyping, multi species
scRNAseq, Spatial Transcriptomics, Bulkseq, multi species
High-dimensional Immunofluorescence, with up to 20 markers in one-shot staining, multi species
Single-cell high-dimensional cell surface marker profiling, human
Cell-free DNA analysis, human
Antigen-specific T Cell Assays, human
High-dimensional antibody Profiling, human

We also provide bioinformatics support for data analysis.

Starting a New Project

To initiate a new project or seek grant support from HIMC, contact Dr. Seunghee Kim-Schulze (seunghee.kim-schulze@mssm.edu) and CC program manager Kai Nie (kai.nie@mssm.edu) for a free consultation. If there is no response after 24 hours, please email Dr. Zhihong Chen (zhihong.chen@mssm.edu).

For questions on scRNAseq, spatial transcriptomics, high-plex IHC/IF, or immune cell phenotyping, please email and Dr. Seunghee Kim-Schulze (seunghee.kim-schulze@mssm.edu) and Dr. Zhihong Chen (zhihong.chen@mssm.edu).

For bioinformatics-related questions, please email Dr. Kim (seunghee.kim-schulze@mssm.edu) and Darwin D’souza (darwin.dsouza@mssm.edu).

HIMC Forms (please open or copy hyperlink in Chrome) and logistics

HIMC New Study Form (for new projects with funding)

HIMC Pre-study Form (for grant support)

HIMC Sample Submission Form (for Assays or Bio-banking)

HIMC Specimen Retrieval Form (for retrieving banked specimen in HIMC for existing studies)

For logistics related to biospecimen collection, drop-off, processing and banking, please reach out to Kai Nie (kai.nie@mssm.edu), Hui Xie (hui.xie@mssm.edu), and Bryan Villagomez (bryan.villagomez@mssm.edu),

Sample Shipment

Ship samples to HIMC using the address provided below. For frozen samples, ship only on Monday/Tuesday and three business days before any observed holiday. For perishable sample, do not ship on Friday or the day before an observed holiday. It is mandatory to notify the relevant HIMC team members with shipment details and tracking numbers before the shipment.

Delivery address:

Attention: Seunghee Kim-Schulze
Human Immune Monitoring Center (HIMC)
Icahn School of Medicine at Mount Sinai
Hess CSM Building, 5th floor, Rm: 310/313
1470 Madison Avenue
New York, NY 10029