The Ronald M. Loeb Center for Alzheimer's Disease

The collaborative spirit that defines The Ronald M. Loeb Center for Alzheimer’s Disease is our greatest strength in tackling Alzheimer's disease. As researchers facing one of medicine's most complex challenges, we recognize that breakthroughs come from diverse perspectives. This philosophy has shaped our Center, where faculty across specialties work seamlessly together. Their collective expertise has sparked innovations ranging from identifying key microglial pathways in disease progression to developing sophisticated blood-brain barrier models that illuminate cerebrovascular contributions to neurodegeneration.

I take particular pride in our efforts to study Alzheimer's disease across diverse populations. By examining genetic risk factors in individuals with varied ancestry, we are ensuring our discoveries and eventual treatments will benefit all communities. Our application of machine learning and artificial intelligence to analyze complex datasets is already yielding insights that would have been impossible just years ago.

The path to effective Alzheimer's treatments remains challenging, but I am optimistic about our direction. Every day, I witness the dedication of our researchers as they unravel disease mechanisms, test potential interventions, and translate findings into clinical applications. With the foundational support of Daniel and Margaret Munzer Loeb and the continued engagement of our broader community, we are advancing toward a day when Alzheimer's disease will no longer devastate families and lives.

Alison M. Goate, DPhil
Director, The Ronald M. Loeb Center for Alzheimer's Disease
Jean C. and James W. Crystal Professor of Genomics
Chair, Department of Genetics and Genomic Sciences
Professor of Neuroscience and Neurology
Icahn School of Medicine at Mount Sinai