Alan J Moskowitz, MD
- PROFESSOR | Population Health Science and Policy
- PROFESSOR | Medicine
Dr. Moskowitz is Co-director of the International Center for Health Outcomes and Innovation Research (InCHOIR), with over 15 years of experience in directing both clinical and data coordinating centers for multicenter clinical trials, both NIH and industry sponsored. He has expertise in designing clinical trials, and overseeing the development of web-based data collection instruments, data management, study monitoring, committee management, interim and final analysis and publication of results. In addition to such traditional endpoints as survival he has expertise with health resource use, quality of life, patient preferences, and functional status. Among other NIH supported clinical trials, he previously directed the clinical coordinating center for the REMATCH trial (left ventricular assist devices (LVAD) as a “destination therapy – 20 clinical centers). In addition to survival, quality of life and patient preferences were key endpoints for this trial. He has also co-directed the DCC for an NHLBI SCCOR project on LVADs and heart failure (12 clinical centers), which conducted multicenter observational and interventional studies related to infection, consumptive coagulopathy and cell therapy for cardiac regeneration. He currently directs the data coordinating center for the NINDS sponsored ARUBA trial (70 clinical centers worldwide) comparing watchful waiting to immediate intervention for patients with unruptured brain AVMS.
Dr. Moskowitz has been in the leadership team for the NHLBI support Cardiothoracic Surgical Trials Network (CTSN) to which he brings expertise in design and analysis of cardiac and neurological trials, functional status, quality of life and economic endpoints. He oversees the adverse event review process and the Biorepository, including the development of a mechanistic study research agenda.
Multi-Disciplinary Training AreaClinical Research Education Program [CLR]
- Surgical Interventions for Moderate Ischemic Mitral Regurgitation
The purpose of the research is to determine whether repairing a mitral valve with moderate leakage, at the time of planned coronary artery bypass graft (CABG) surgery, will improve health outcomes of those who receive it compared to those who don’t. There are no new or “experi...
- An Observational, ex vivo Clinical Trial of Intrinsic Pathway Antagonists in Patients Undergoing Warfarin Therapy
The purpose of this multi-center, controlled trial is to examine the ex vivo effects of TTP 889 vs. vehicle alone (DMSO) on clotting time of plasma obtained from patients on warfarin anticoagulation for therapeutic reasons.
- A Randomized Clinical Trial of Intrinsic Pathway Antagonists in Patients Undergoing Implantation of Left Ventricular Assist Devices
The purpose of this study is to evaluate the administration of TTP889 in patients following LVAD (Left Ventricular Assist Device) implantation by examining its effects on thrombin generation markers. This Phase II trial should support a Phase III trial in evaluating the effica...
- A Randomized Multicenter Clinical Trial of Unruptured Brain Arteriovenous malformations (ARUBA)
The purpose of this research is to compare medical management to interventional therapy (with either endovascular treatment, neurosurgery, or radiotherapy) for the treatment of patients with unruptured (unbled) arteriovenous malformations (AVM) of the brain. What is not known ...
- Evaluation of Outcomes Following Mitral Valve Repair/Replacement in Severe Chronic Ischemic Mitral Regurgitation
The purpose of this research is to determine whether it is better to repair or replace the mitral valve of patients with severe mitral valve leakage (regurgitation) from coronary artery disease. There are no new or “experimental” procedures being tested in this study and fixin...
Mohr JP, Moskowitz AJ, Parides M, Stapf C, Young WL. Hull Down on the Horizon: A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA) Trial. Stroke 2012 Jun 5;(Epub ahead of print).
Perrault LP, Moskowitz AJ, Kron IL MD, Acker MA, Miller MA, Horvath KA, Thourani VH, Argenziano M, D’Alessandr DA, Blackstone EH, Moy CS, Mathew MD, Hung J, Gardner TJ, Parides MK. Optimal Surgical Management of Severe Ischemic Mitral Regurgitation: To Repair or to Replace? . J Thorac Cardiovasc Surg 2012 Jun; 143(6): 1396-403.Epub 2011 Nov 4.
Frontera JA, Egorova N, Moskowitz AJ. National trend in prevalence, cost, and discharge disposition after subdural hematoma from 1998-2007. Crit Care Med 2011 Jul; 39(7): 1619-25.
Mohr JP, Moskowitz AJ, Stapf C, Hartmann A, Weinberg A, Young WL, Estevez A, Kureshi I, Brisman JL. The ARUBA trial: current status, future hopes. Stroke 2010 Aug; 41(8).
Egorova NN, Gelijns AC, Moskowitz AJ, Emond JC, Krapf R, Lazar EJ, Guillerm