Arthur P Goldberg

Arthur P Goldberg, PhD

  • ASSOCIATE PROFESSOR | Genetics and Genomic Sciences

Research Topics:

Autism, Bacterial Genetics, Bioinformatics, Biomedical Informatics, Biophysics, Cancer Genetics, Cell Biology, Computational Biology, Computer Simulation, Genetics, Genomics, Human Genetics and Genetic Disorders, Mathematical Modeling of Biomedical Systems, Mathematical and Computational Biology, Systems Biology

Professor Goldberg has a degree in Astrophysics from Harvard and a PhD in Computer Science from UCLA. He entered bioinformatics after a distinguished career researching distributed software at IBM Research and network protocol performance at NYU’s Courant Institute of Mathematical Sciences.

The aim of his current work is to help researchers achieve human whole-cell (WC) models that enable physicians to personalize medicine. To this end, he develops algorithms and software for building, simulating, and analyzing WC models. WC models are computational models that predict how genotype influences phenotype by accounting for every gene function in a cell. His methods systemize and accelerate WC modeling and enable scientists to efficiently build and simulate WC models. In particular, he is inventing methods that enable researchers to create models of human cells that represent all annotated human genes and can guide medicine by screening drugs in silico.

Previously, as a Research Scientist in Bioinformatics in the Plant Systems Biology Laboratory at NYU he co-designed and co-implemented the Virtual Plant System, which provides tools to conveniently visualize and analyze gene expression and network data about the model plant Arabidopsis and crops.

At Sloan-Kettering, Dr. Goldberg co-designed and co-developed the cBioPortal for Cancer Genomics, a website that enables researchers to visualize and analyze multiple types of cancer genetic data. The cBioPortal stores all of the NCI’s reduced Cancer Genome Atlas (TCGA) data, along with data from multiple other studies.

As a member of the Seaver Autism Center in the Icahn School of Medicine at Mount Sinai, Prof. Goldberg studied the genetic causes of autism. He was the founding Director of the Bioinformatic Hub for the NIMH-funded Autism Sequencing Consortium (ASC). The Hub stores published and unpublished sequence data and called variants from autism studies by ASC members and provides secure, shared data access and cluster computing to ASC members. Dr. Goldberg built a three person bioinformatics team for the Seaver Center.

Education

BA, Harvard College

PhD, University of California, Los Angeles