Beatriz G Pogo, MD
- PROFESSOR EMERITUS | Medicine, Hematology and Medical Oncology
Specialty: Viral Oncology
DMSc, Buenos Aires University School of Medicine
MD, Buenos Aires University School of Medicine
Sloan Kettering Institute Cancer Center
Outstanding Women in Science Award
Damon Runyon Fund Fellowship
Research Career Award
The main research of this laboratory concerns molecular mechanisms of viral pathogenesis.
Fifteen percent of human cancers are associated with or caused by viruses. We are investigating if a virus similar to the mouse mammary tumor virus (MMTV) is involved in human breast cancer pathogenesis. We have found viral sequences similar to MMTV in 38% of the human breast cancers tested. They were expressed as RNA and proteins. A complete proviral structure has been detected with the characteristics of a replicative competent virus.
Recently, we isolated and characterized a beta retrovirus from primary cultures of human breast cancer cells. The retrovirus is able to infect epithelial and lymphocytic human cells. Its potential for malignant transformation is being investigated. Epidemiological studies on breast cancer and retroviral incidence are also carried out by analyzing samples from different geographical locations. The transcriptional profile of breast cancer cells carrying the virus was also investigated. Together, these studies will help to determine if a retrovirus is involved in human breast cancer pathogenesis.
Pogo BG T, Melana SM, Holland J, Mandeli JF, Piloti S, Casalini P, Menard S. Sequences homologous to the MMTV env gene in human breast carcinoma correlate with overexpression of laminin receptor. Clin Cancer Res 1999; 5(8): 2108-11.
Liu B, Wang Y, Melana SM, Pelisson I, Najfeld V, Holland JF, Pogo BG. Identification of a proviral structure in human breast cancer. Cancer Res 2001 Feb; 61(4): 1754-9.
Melana SM, Holland JF, Pogo BG. Search for mouse mammary tumor virus-like env sequences in cancer and normal breast from the same individuals. Clin Cancer Res 2001; 7: 283-284.
Wang Y, Jiang JD, Xu D, Qu C, Holland JF, Pogo BG. A mouse mammary tumor virus-like long terminal repeat superantigen in human breast cancer. Cancer Res 2004 Jun; 64(12): 4105-11.
Levine PH, Pogo BG, Klouj A, Coronel S, Woodson K, Melana SM, Mourali N, Holland JF. Increasing evidence for a human breast carcinoma virus with geographic differences. Cancer 2004 Aug; 101(4): 721-6.
Holland JF, Pogo BG. Mouse mammary tumor virus-like viral infection and human breast cancer. Clin Cancer Res 2004 Sep; 10(17): 5647-9.
Fernandez-Cobo M, Melana SM, Holland JF, Pogo BG. Transcription profile of a human breast cancer cell line expressing MMTV-like sequences. Infect Agent Cancer 2006 Dec; 1: 7.
Fernandez-Cobo M, Holland JF, Pogo BG. Transcription profiles of non-immortalized breast cancer cell lines. BMC Cancer 2006 Apr; 6: 99.
Melana SM, Nepomnaschy I, Sakalian M, Abbott A, Hasa J, Holland JF, Pogo BT. Characterization of viral particles isolated from primary cultures of human breast cancer cells. Cancer Research 2007; 67: 8960-8965.
Pogo BG MD, Holland JF MD, Levine PP MD. Human mammary tumor virus in inflammatory breast cancer. Cancer 2010; 116(Suppl 11): 241-244.
Melana SM, Nepomnaschy I, Hasa J, Djougarian A, Holland JF, Pogo BG. Expression of HMTV proteins in human breast cancer. J Virol. Methods 2010; 163: 153-161.
Pogo BG, Holland JF. Carcinogenesis of breast cancer. In: Carcinogenesis of breast cancer. Netherlands, Springer; pp109-115.
Pogo BG, Melana SM, Moran H, Holland JF. Presence of MMTV-like env gene sequences in human breast cancer. Breast cancer research and treatment 2010; 125: 295-297.
Deligdisch L, Marin T, Lee AT, Etkind P, Holland JF, Melana SM, Pogo BG. Human mammary tumor virus (HMTV) in endometrial cancer. Intl J Gynecol Cancer 2013; 23: 1423-1428.
Nartey T, Moran H, Marin T, Arcaro KF, Anderton DL, Etkind P, Holland JF, Melana SM, Pogo BG. Human Mammary Tumor Virus (HMTV) sequences in human milk. Infectious Agents and Cancer 2014; 9: 20-28.