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Christoph Buettner

  • ASSOCIATE PROFESSOR Medicine, Endocrinology, Diabetes and Bone Disease
  • ASSOCIATE PROFESSOR Neuroscience
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Research

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Our interest is to understand how hormones and nutrients are sensed by the hypothalamus and how the brain controls systemic metabolism. In rodent models of obesity and in type 2 diabetes this brain control of metabolism is impaired and we believe this dysfunction plays an important role in the pathogenesis of both of these conditions. Interestingly, diabetes and obesity are associated with a pro-inflammatory state. We have found that hormones like insulin and leptin regulate systemic inflammation via the brain and the autonomic nervous system and speculate that this may be the basis for the link between impaired metabolic control and inflammation. A commonly used approach in our lab is to study nutrient fluxes with clamp studies combined with metabolic tracers in rodents.

Publications

Li JH, Gautam D, Han SJ, Guettier JM, Cui Y, Lu H, Deng C, O'Hare J, Jou W, Gavrilova O, Buettner C, Wess J. Hepatic Muscarinic Acetylcholine Receptors are not Critically involved in Maitning Glucose Homeostasis in Mice. Diabetes 2009 September;.

Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, Hwang D, Barzilai N, Cohen P. Humanin: A Novel Central Regulator of Peripheral Insulin Action.. PloS One 2009 July; 4(7): e6334.

Scherer T, Buettner C. The Dysregulation of the Endocannabinoid System in Diabesity-a Tricky Problem. J Mol Med 2009 March;.

Buettner C, Camacho RC. Hypothalamic Control of hepatic Glucose Production and Its Potential Role in Insulin Resistance. Endocrinol Metab Clin North Am 2008 December; 37(4): 825-840.

Osei-Hyiaman D, Liu J, Zhou L, Godlewski G, Harvey-White J, Jeong WI, Batkai S, Marsicano G, Lutz B, Buettner C, Kunos G. Hepatic CB1 Receptor is Required for Development of Diet-Induced Steatosis, Dyslipidemia, and Insulin and Leptin Resistance in Mice. J Clin Invest 2008 September; 118(9): 3160-3169.

Buettner C, Muse ED, Pocai A, Chen A, Kai S, Chen L, Harvey-White J, Kunos G, Rossetti L. Leptin Control Adipose Tissue Endocannabinoids and Lipogenesis Via Central, STAT3 Independent Pathways. Nat. Med 2008 June; 14(6): 667-675.

Buettner C. Does FASing Out New Fat In The Hypothalamus Make You Slim?. Cell Metab 2007 October; 6(4): 249-251.

Buettner C, Pocai A, Muse ED, Etgen A, Myers M, Rossetti L. The Role of Stat3 in The Metabolic Actions of Leptin. Cell Met. 2006 July; 4: 49-60.

Pocai A, Morgan K, Buettner C, Gutierrez-Juarez R, Obici S, Rossetti L. Central Leptin Acutely Reverses Diet-Induced Hepatic Insulin Resistance. Diabetes 2005 Nov; 54(11): 3182-3189.

Severe impairment in Liver Insulin Signaling Fails to Alter Hepatic Insulin Action in Mice. Severe Impairment in Liver Insulin Signaling Fails to Alter Hepatic Insulin Actions in Conscious Mice. J Clin. Invest 2005 May;(115): 1306-1313.

O'Hare J, Zielinski E, Cheng B, Scherer T, Buettner C. Central endocannabinoid signaling regulates hepatic glucose production and systemic lipolysis. Diabetes;.

Scherer T, O'Hare J, Diggs-Andrews K, Schweiger M, Cheng B, Lindtner C, Zielinski E, Su K, Dighe S, Milsom T, Puchowicz M, Scheja L, Zechner R, Fisher S, Previs S, Buettner C. Brain insulin controls adipose tissue function. Cell Met 2011 February; 13(2): 183-194.

Scherer T, Buettner C. Yin and Yang of Hypothalamic Insulin and Leptin Signaling in Regulating White Adipose Tissue Metabolism. Reviews in Endocrine and Metabolic Disorders;.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Buettner did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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Tel: 212-241-3425