Eric J Nestler, MD, PhD
- DEAN FOR ACADEMIC AND SCIENTIFIC AFFAIRS
- DIRECTOR FRIEDMAN BRAIN INSTITUTE
- PROFESSOR & CHAIR | Neuroscience
- PROFESSOR | Pharmacology and Systems Therapeutics
- PROFESSOR | Psychiatry
Research Topics:Addiction, Behavior, Depression, Epigenetics, Molecular Biology, Neuroscience, Synapses, Synaptic Plasticity, Synaptogenesis
Dr. Nestler is the Nash Family Professor of Neuroscience and Director of the Friedman Brain Institute. His laboratory studies the molecular mechanisms of drug addiction and depression in animal models.
Visit Eric Nestler's Laboratory of Molecular Psychiatry, Conte Center on Depression and NIDA Program Project Grant for more information.
Psychiatry, American Board of Psychiatry and Neurology
Multi-Disciplinary Training AreasBiophysics and Systems Pharmacology [BSP], Neuroscience [NEU]
MD, Yale University School of Medicine
PhD, Yale University
Internship, Medicine/Psychiatry, Mclean Hospital
Residency, Psychiatry, Yale University School of Medicine
Fellowship, Pharmacology, Yale University School of Medicine
Fellowship, Psychiatry, Yale University School of Medicine
Sarnat Prize, Institute of Medicine
American Academy of Arts and Science
Institute of Medicine
Nestler Lab, Laboratory of Molecular Psychiatry
Specific Clinical/Research Interest: Molecular neurobiology of drug addiction and depression; transcriptional and epigenetic regulation in the brain.
Current Students: Hannah Cates, Hope Kronman, Casey Lardner, Efrain Ribeiro, Zach Lorsch
Postdoctoral Fellows: Rosemary Bagot, Michael Cahill, Erin Calipari, Olivia Engmann, Peter Hamilton, Orna Issler, Benoit Labonte, Catherine Peña, Deena Walker
Research Personnel: Zeke Mouzon (Lab Manager), Dominika Burek, Nicolle Strat
Our research focuses on identifying the neurobiological basis of drug addiction and depression in rodent models. We study the molecular and cellular changes that occur in regions of the brain important for reward and motivation in response to chronic administration of a drug of abuse or chronic exposure to stress. We are particularly interested in long-lasting changes that are mediated via alterations in gene expression and chromatin remodeling. The result of the research will guide future efforts toward the development of more effective treatments for addiction and depression.
For more, please visit Selected Publications:
Heller EA, Cates HM, Peña CJ, Sun H, Shao N, Feng J, Golden SA, Herman JP, Walsh JJ, Mazei-Robison M, Ferguson D, Knight S, Gerber MA, Nievera C, Han MH, Russo SJ, Tamminga CS, Neve RL, Shen L, Zhang HS, Zhang F, Nestler EJ. Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors. Nature neuroscience 2014 Dec; 17(12).
Dias C, Feng J, Sun H, Shao NY, Mazei-Robison MS, Damez-Werno D, Scobie K, Bagot R, LaBonté B, Ribeiro E, Liu X, Kennedy P, Vialou V, Ferguson D, Peña C, Calipari ES, Koo JW, Mouzon E, Ghose S, Tamminga C, Neve R, Shen L, Nestler EJ. β-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature 2014 Nov;.
Maze I, Shen L, Zhang B, Garcia BA, Shao N, Mitchell A, Sun H, Akbarian S, Allis CD, Nestler EJ. Analytical tools and current challenges in the modern era of neuroepigenomics. Nature neuroscience 2014 Nov; 17(11).
Bagot RC, Labonté B, Peña CJ, Nestler EJ. Epigenetic signaling in psychiatric disorders: stress and depression. Dialogues in clinical neuroscience 2014 Sep; 16(3).
Dong Y, Nestler EJ. The neural rejuvenation hypothesis of cocaine addiction. Trends in pharmacological sciences 2014 Aug; 35(8).
Mitchell AC, Bharadwaj R, Whittle C, Krueger W, Mirnics K, Hurd Y, Rasmussen T, Akbarian S. The genome in three dimensions: a new frontier in human brain research. Biological psychiatry 2014 Jun; 75(12).
Shen L, Shao N, Liu X, Nestler E. ngs.plot: Quick mining and visualization of next-generation sequencing data by integrating genomic databases. BMC genomics 2014; 15.
Maze I, Noh KM, Soshnev AA, Allis CD. Every amino acid matters: essential contributions of histone variants to mammalian development and disease. Nature reviews. Genetics 2014 Apr; 15(4).
Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun H, Turecki G, Neve RL, Hurd YL, Shen L, Han MH, Schaefer A, Nestler EJ. G9a influences neuronal subtype specification in striatum. Nature neuroscience 2014 Apr; 17(4).