Photo of Gwen S. Skloot

Gwen S. Skloot

  • ASSOCIATE PROFESSOR Medicine, Pulmonary, Critical Care and Sleep Medicine
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Specialty

Certifications

  • Critical Care Medicine

  • Pulmonary Disease

Education

  • MD, New York University

  • Internship, Internal Medicine
    Mount Sinai Hospital

  • Residency, Internal Medicine
    Mount Sinai Hospital

  • Fellowship, Pulm & Critical Care
    Johns Hopkins Hospital

Biography

    News

    Mount Sinai Study Finds One Quarter of WTC Responders Continue to Have Lung Function Impairment

    Find out more here

    Dr. Gwen Skloot discusses the link between asthma and obesity in The Daily News feature The Daily Check Up.


Research

Airway Responsiveness in Asthma

Our laboratory focuses on clinical asthma studies. We hypothesize that hyperresponsiveness is caused by impairment in the ability of inspiration to stretch airway smooth muscle (ASM) -- i.e. impaired bronchodilation. This hypothesis is supported by our finding that sensitivity to the constrictor agent Methacholine is the same in normals and asthmatics when challenge is conducted without deep breaths. It is also known that deep inspiration (DI) prior to a constrictor agent is bronchoprotective in normal subjects. We have shown that this effect relates to inspiratory velocity, i.e. a fast DI is more bronchoprotective than a slow DI. We speculate that in healthy subjects, DI stretches ASM and breaks cross bridges and that cross bridge breakage is enhanced with increased inspiratory velocity. In asthmatics, inflammation may impair this ability. Further protocols will focus on the mechanism of the impaired response to DI in asthma in order to ultimately develop interventions to treat this aspect of hyperresponsiveness.

We have developed an in vitro model to test similar ideas. We hypothesize that stretching guinea pig (GP) tracheal smooth muscle releases a humoral "relaxant" factor [i.e. stretch-induced relaxation (SIR) involves a receptor-mediated mechanism]. The analogous in vivo situation may be the release of a "bronchodilating" substance when a normal subject takes a deep breath. This bronchodilating substance may be decreased in asthma. We have demonstrated that GP tracheal smooth muscle does relax when stretched; this relaxation is enhanced post-carbachol. We have characterized this relaxation response by pharmacokinetic studies. Additional characterization studies are focused on inhibiting the SIR response with agents such as beta-blockers, indomethacin, etc. We have shown that after induction of airway inflammation, the SIR response is reduced. Future protocols will address the mechanism of this reduced response and the relevance to human asthma.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Skloot during 2012 and/or 2013. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Scientific Advisory Board:

  • Teva Pharmaceutical Industries Ltd.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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Pulmonary, Critical Care & Sleep Medicine

5 East 98th Street
10th Floor
New York, NY 10029

Tel: 212-241-5656
Fax: 212-241-8866
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Office Hours:
  • Monday 9:00am - 5:00pm
  • Tuesday 9:00am - 5:00pm
  • Wednesday 9:00am - 5:00pm
  • Thursday 9:00am - 5:00pm
  • Friday 9:00am - 5:00pm
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  • Cigna - PPO
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  • Devon Health Services
  • Fidelis Care NY - HMO
  • First Health
  • Group Health Insurance (GHI) - HMO
  • Group Health Insurance (GHI) - PPO
  • HIP Commercial
  • HIP Medicaid
  • HIP Medicare
  • HealthFirst/Medicaid HMO
  • HealthNet
  • HealthPlus, Inc.
  • Island Group
  • Local 1199
  • Magnacare
  • MedCare International
  • Medicaid
  • Medicaid New Jersey
  • Medicare
  • MetroPlus Health Plan
  • Multiplan/PHCS
  • Neighborhood Health Providers, LLC
  • Oxford Freedom
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  • Travel Care Services
  • United Health Care - Mount Sinai Top Tier
  • United Health Care Commercial
  • United Health Care Empire Plan
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