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Dani Dumitriu

  • INSTRUCTOR Neuroscience
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Education

  • B.S., University of California, Santa Barbara

  • M.D./Ph.D., Icahn School of Medicine at Mount Sinai

Biography

    My research focuses on understanding the neurobiological basis for resilience. In particular, I am interested in how the brains of resilient individuals are wired with the ability to withstand adversity. Currently, we are working on a mouse model involving social defeat, and we are trying to develop predictive measures of resilience using a combination of behavioral tasks, high resolution confocal microscopy of dendritic spines, and resting state fRMI. Ultimately, I am interested in developing tools that will enhance the neural networks for resilience in children, with the ultimate goal of contributing to the promotion of happier, healthier lives.

Awards

  • 2008 - 2012
    National Research Service Award (NRSA), F30, NIMH

Publications

Dumitriu D, Berger SI, Hamo C, Hara Y, Bailey M, Hamo A, Grossman YS, Janssen WG, Morrison JH. Vamping: stereology-based automated quantification of fluorescent puncta size and density. Journal of Neuroscience Methods 2012 Jul; 209(1).

Dumitriu D. Right Brain: past medical story. Neurology 2012 Sep; 79(12).

Dumitriu D, Laplant Q, Grossman YS, Dias C, Janssen WG, Russo SJ, Morrison JH, Nestler EJ. Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens. The Journal of Neuroscience 2012 May; 32(20).

Dumitriu D, Rodriguez A, Morrison JH. High-throughput, detailed, cell-specific neuroanatomy of dendritic spines using microinjection and confocal microscopy. Nature Protocols 2011 Sep; 6(9).

Christoffel DJ, Golden SA, Dumitriu D, Robison AJ, Janssen WG, Ahn HF, Krishnan V, Reyes CM, Han MH, Ables JL, Eisch AJ, Dietz DM, Ferguson D, Neve RL, Greengard P, Kim Y, Morrison JH, Russo SJ. IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity. The Journal of Neuroscience 2011 Jan; 31(1).

Dumitriu D, Rapp PR, McEwen BS, Morrison JH. Estrogen and the aging brain: an elixir for the weary cortical network. Annals of the New York Academy of Sciences 2010 Aug; 1204.

Dumitriu D, Hao J, Hara Y, Kaufmann J, Janssen WG, Lou W, Rapp PR, Morrison JH. Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment. The Journal of Neuroscience 2010 Jun; 30(22).

Russo SJ, Dietz DM, Dumitriu D, Morrison JH, Malenka RC, Nestler EJ. The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends in Neurosciences 2010 Jun; 33(6).

LaPlant Q, Vialou V, Covington HE, Dumitriu D, Feng J, Warren BL, Maze I, Dietz DM, Watts EL, Iñiguez SD, Koo JW, Mouzon E, Renthal W, Hollis F, Wang H, Noonan MA, Ren Y, Eisch AJ, Bolaños CA, Kabbaj M, Xiao G, Neve RL, Hurd YL, Oosting RS, Fan G, Morrison JH, Nestler EJ. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nature Neuroscience 2010 Sep; 13(9).

Dumitriu D, Collins K, Alterman R, Mathew SJ. Neurostimulatory therapeutics in management of treatment-resistant depression with focus on deep brain stimulation. The Mount Sinai Journal of Medicine 2008; 75(3).

Dumitriu D, Cossart R, Huang J, Yuste R. Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex. Cerebral Cortex 2007 Jan; 17(1).

Gotay CC, Dumitriu D. Health food store recommendations for breast cancer patients. Archives of family medicine 2000 Aug; 9(8).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr.Dumitriu is not currently required to report Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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