- INSTRUCTOR Neuroscience
- I am currently conducting independent basic science research while simultaneously completing a residency in General Pediatrics at Mount Sinai. My research focuses on understanding the neurobiological basis for resilience, i.e. the brain wiring that gives some individuals the ability to withstand adversity. Currently, my lab is working on a mouse model of social defeat and developing predictive measures of resilience using a combination of behavioral tasks, high resolution confocal microscopy, and resting state fRMI. My ultimate goal is to pioneer "developmental neuroprevention" by creating tools that will enhance resiliency neural networks in children, thereby leading to happier, healthier lives.
2015 - 2017
NARSAD Young Investigator Award
Brain and Behavior Research Foundation
2008 - 2012
National Research Service Award (F30 NRSA)
Pereira AC, Lambert HK, Grossman YS, Dumitriu D, Waldman R, Jannetty SK, Calakos K, Kalakos WG, McEwen BS, Morrison JH. Glutamatergic regulation prevents hippocampal-dependent age-related cognitive decline through dendritic spine clustering. Proc Natl Acad Sci 2014; 111(52).
Young ME, Ohm DT, Dumitriu D, Rapp PR, Morrison JH. Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey. Neuroscience 2014 Aug; 274.
Dumitriu D, Berger SI, Hamo C, Hara Y, Bailey M, Hamo A, Grossman YS, Janssen WG, Morrison JH. Vamping: stereology-based automated quantification of fluorescent puncta size and density. Journal of Neuroscience Methods 2012 Jul; 209(1).
Dumitriu D. Right Brain: past medical story. Neurology 2012 Sep; 79(12).
Dumitriu D, Laplant Q, Grossman YS, Dias C, Janssen WG, Russo SJ, Morrison JH, Nestler EJ. Subregional, dendritic compartment, and spine subtype specificity in cocaine regulation of dendritic spines in the nucleus accumbens. The Journal of Neuroscience 2012 May; 32(20).
Dumitriu D, Rodriguez A, Morrison JH. High-throughput, detailed, cell-specific neuroanatomy of dendritic spines using microinjection and confocal microscopy. Nature Protocols 2011 Sep; 6(9).
Christoffel DJ, Golden SA, Dumitriu D, Robison AJ, Janssen WG, Ahn HF, Krishnan V, Reyes CM, Han MH, Ables JL, Eisch AJ, Dietz DM, Ferguson D, Neve RL, Greengard P, Kim Y, Morrison JH, Russo SJ. IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity. The Journal of Neuroscience 2011 Jan; 31(1).
Dumitriu D, Rapp PR, McEwen BS, Morrison JH. Estrogen and the aging brain: an elixir for the weary cortical network. Annals of the New York Academy of Sciences 2010 Aug; 1204.
Dumitriu D, Hao J, Hara Y, Kaufmann J, Janssen WG, Lou W, Rapp PR, Morrison JH. Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment. The Journal of Neuroscience 2010 Jun; 30(22).
Russo SJ, Dietz DM, Dumitriu D, Morrison JH, Malenka RC, Nestler EJ. The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends in Neurosciences 2010 Jun; 33(6).
LaPlant Q, Vialou V, Covington HE, Dumitriu D, Feng J, Warren BL, Maze I, Dietz DM, Watts EL, Iñiguez SD, Koo JW, Mouzon E, Renthal W, Hollis F, Wang H, Noonan MA, Ren Y, Eisch AJ, Bolaños CA, Kabbaj M, Xiao G, Neve RL, Hurd YL, Oosting RS, Fan G, Morrison JH, Nestler EJ. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nature Neuroscience 2010 Sep; 13(9).
Dumitriu D, Collins K, Alterman R, Mathew SJ. Neurostimulatory therapeutics in management of treatment-resistant depression with focus on deep brain stimulation. The Mount Sinai Journal of Medicine 2008; 75(3).
Dumitriu D, Cossart R, Huang J, Yuste R. Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex. Cerebral Cortex 2007 Jan; 17(1).
Gotay CC, Dumitriu D. Health food store recommendations for breast cancer patients. Archives of family medicine 2000 Aug; 9(8).
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr.Dumitriu is not currently required to report Industry relationships.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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