Photo of Istvan Sugar

Istvan Sugar

  • ASSOCIATE PROFESSOR Neurology
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Education

  • Ph.D, Eötvös Loránd University
    Theoretical Physics

  • Ph.D., Hungarian Academy of Science
    Biophysics

Research

Dr. Sugár has made important contributions to theoretical biophysics by 1) deriving exact solutions of the fundamental equations of fluorescence and NMR spectroscopy, 2) constructing stochastic models of cell electroporation and electrofusion, 3) simulating two-component phospholipid membranes by Monte Carlo techniques, 4) developing a statistical mechanical model of sterol/phospholipid mixtures, 5) modeling peripheral protein adsorption on the water/lipid interface, and 6) studying the effect of  epithelial membrane geometry on autocrine/paracrine signaling. Recently he also contributed to the reliable analysis of high dimensional flow cytometry data by developing a fast clustering method and an improved method for compensation. 

Publications

Sugár IP, Chong PL. A Statistical Mechanical Model of Cholesterol/Phospholipid Mixtures: Linking Condensed Complexes, Superlattices, and the Phase Diagram. Journal of the American Chemical Society 2011 Dec;.

Sugár IP, González-Lergier J, Sealfon SC. Improved compensation in flow cytometry by multivariable optimization. Cytometry. Part A : the journal of the International Society for Analytical Cytology 2011 May; 79(5).

Sugár IP, Sealfon SC. Misty Mountain clustering: application to fast unsupervised flow cytometry gating. BMC bioinformatics 2010; 11.

Sugár IP, Sealfon SC. Model of autocrine/paracrine signaling in epithelial layer: geometrical regulation of intercellular communication. The journal of physical chemistry. B 2009 Aug; 113(31): 10946-10956.

Sugár IP, Brockman HL. Model of peripheral protein adsorption to the water/lipid interface. The journal of physical chemistry. B 2007 Apr; 111(16): 4073-4081.

Sugar IP, Lindesay J, Schmukler RE. Phenomenological theory of low-voltage electroporation Electric field calculation. J Phys Chem B 2003; 107: 3862-3870.

Sugár IP, Thompson TE, Biltonen RL. Monte Carlo simulation of two-component bilayers: DMPC/DSPC mixtures. Biophysical journal 1999 Apr; 76(4): 2099-2110.

Sugár IP. General method for finding explicit relationships between jump models of intramolecular dynamics and spectral densities. The journal of physical chemistry 1992; 96: 10719-10724.

Sugár IP. Use of Fourier transforms in the analysis of fluorescence data. 1. A general method for finding explicit relationships between photophysical models and fluorescence parameters. The journal of physical chemistry 1991; 95: 7508-7515.

Sugar IP, Neumann E. Stochastic model for electric field-induced membrane pores. Electroporation. Biophysical chemistry 1984 May; 19(3): 211-225.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Sugar did not report having any of the following types of financial relationships with industry during 2013 and/or 2014: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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