James C Iatridis, PhD
- PROFESSOR | Orthopaedics
- PROFESSOR | Neurosurgery
Research Topics:Biomechanics/Bioengineering, Developmental Biology, Mathematical Modeling of Biomedical Systems, Regeneration, Spinal Cord, Translation
Dr. Iatridis is Professor and Vice Chair for Research in the Leni and Peter W. May Department of Orthopaedics at the Icahn School of Medicine at Mount Sinai in New York City. Dr. Iatridis joined Mount Sinai in 2010 to drive his spine research in translational directions and serves as Director of Spine Research of the Mount Sinai Health System. Dr. Iatridis is very involved in graduate education as Mount Sinai and serves as Co-Director of the Design, Technology and Entrepreneurship training area of the PhD in Biomedical Sciences. Since 2015, Dr. Iatridis holds the Mount Sinai Endowed Professorship in Orthopaedic Research. Dr. Iatridis graduated from Franklin and Marshall College with a B.A. in Physics, and then completed his B.S., M.S. and Ph.D. from Columbia University in Mechanical Engineering with Dr. Van C. Mow as his graduate mentor. Following his graduate studies, Dr. Iatridis was a post-doctoral fellow in the Department of Orthopaedics & Rehabilitation at the University of Vermont under the guidance of Dr. Ian Stokes. Dr. Iatridis became faculty in the School of Engineering at UVM in 1999, retaining a joint appointment in Orthopaedics & Rehabilitation, and going through promotion to full professor. He has also been Visiting Professor at the AO Research Institute in Davos Switzerland working with Mauro Alini and Adjunct Investigator at the Cartilage Biology and Orthopaedics Branch of the NIH in Bethesda, MD, working with Rocky Tuan.
Multi-Disciplinary Training AreasBiophysics and Systems Pharmacology [BSP], Developmental and Stem Cell Biology [DSCB]
BA, Franklin and Marshall College
PhD, Columbia University
Post-doctoral Fellowship, University of Vermont
Henry Farfan Award
Berton Rahn Research Prize
Presidential Early Career Award for Scientists and Engineers (PECASE)
Macnab LaRocca Fellowship
Spine Mechanobiology, Tissue Engineering and Regenerative Medicine
Our laboratory is interested in investigations of functional changes in the spine in response to loading and injury, and investigations of promising therapeutic techniques to promote spine health and repair. Our investigations span biomechanics, mechanobiology, tissue engineering, anti-inflammatory and cellular therapies. Through our animal, cell, and organ culture studies we have a focus on models of injury and repair with high relevance to human clinical conditions. Our research balances exploration of fundamental mechanisms and translation with appreciation for the development and maturation processes in human joints that promote health and disease processes.
Dr. Iatridis’ research focus is on the development of early and minimally invasive treatments to prevent or repair injured and degenerated intervertebral discs. He has investigated problems in the intervertebral disc since 1994, and has published over 60 papers in the field of orthopaedics. Dr. Iatridis received grants from the NIH, Whitaker Foundation, and AO Foundation. He was awarded a Presidential Early Career Award for Scientists and Engineers (PECASE) in 2008, and the Berton Rahn Research Prize of the AO Research Fund in 2009 and the Henry Farfan Award for Spine Basic Sciences of the North American Spine Society in 2015. Dr. Iatridis is very active in his research community having reviewed for over 20 journals and 6 funding agencies, he currently serves on the editorial board of 2 journals. Dr. Iatridis current serves as Chair of the newly formed Spine Section of the Orthopaedic Research Society and previously served as member and Chair of the NIH Skeletal Biology Structure and Regeneration Study Section.
Purmessur D, Cornejo MC, Cho SK, Hecht AC, Iatridis JC. Notochordal Cell-Derived Therapeutic Strategies for Discogenic Back Pain. Global spine journal 2013 Jun; 3(3).
Illien-Junger S, Grosjean F, Laudier DM, Vlassara H, Striker GE, Iatridis JC. Combined anti-inflammatory and anti-AGE drug treatments have a protective effect on intervertebral discs in mice with diabetes. PloS one 2013; 8(5).
Iatridis JC, Nicoll SB, Michalek AJ, Walter BA, Gupta MS. Role of biomechanics in intervertebral disc degeneration and regenerative therapies: what needs repairing in the disc and what are promising biomaterials for its repair?. The spine journal : official journal of the North American Spine Society 2013 Mar; 13(3).
Guterl CC, See EY, Blanquer SB, Pandit A, Ferguson SJ, Benneker LM, Grijpma DW, Sakai D, Eglin D, Alini M, Iatridis JC, Grad S. Challenges and strategies in the repair of ruptured annulus fibrosus. European cells & materials 2013; 25.
Mayer JE, Iatridis JC, Chan D, Qureshi SA, Gottesman O, Hecht AC. Genetic polymorphisms associated with intervertebral disc degeneration. The spine journal : official journal of the North American Spine Society 2013 Mar; 13(3).
Long RG, Torre OM, Hom WW, Assael DJ, Iatridis JC. Design Requirements for Annulus Fibrosus Repair: Review of Forces, Displacements, and Material Properties of the Intervertebral Disk and a Summary of Candidate Hydrogels for Repair. Journal of biomechanical engineering 2016 Feb; 138(2).
Walter BA, Purmessur D, Likhitpanichkul M, Weinberg A, Cho SK, Qureshi SA, Hecht AC, Iatridis JC. Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells. Spine 2015 Jul; 40(13).
Likhitpanichkul M, Kim Y, Torre OM, See E, Kazezian Z, Pandit A, Hecht AC, Iatridis JC. Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFα drug. The spine journal : official journal of the North American Spine Society 2015 Sep; 15(9).
Skovrlj B, Koehler SM, Anderson PA, Qureshi SA, Hecht AC, Iatridis JC, Cho SK. Association Between BMP-2 and Carcinogenicity. Spine 2015 Dec; 40(23).
Walter BA, Torre OM, Laudier D, Naidich TP, Hecht AC, Iatridis JC. Form and function of the intervertebral disc in health and disease: a morphological and stain comparison study. Journal of anatomy 2015 Dec; 227(6).
Illien-Jünger S, Sedaghatpour DD, Laudier DM, Hecht AC, Qureshi SA, Iatridis JC. Development of a bovine decellularized extracellular matrix-biomaterial for nucleus pulposus regeneration. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2015 Oct;.
Gantenbein B, Illien-Jünger S, Chan SC, Walser J, Haglund L, Ferguson SJ, Iatridis JC, Grad S. Organ culture bioreactors--platforms to study human intervertebral disc degeneration and regenerative therapy. Current stem cell research & therapy 2015; 10(4).
Walter BA, Likhitpanichkul M, Illien-Junger S, Roughley PJ, Hecht AC, Iatridis JC. TNFα transport induced by dynamic loading alters biomechanics of intact intervertebral discs. PloS one 2015; 10(3).
Purmessur D, Cornejo MC, Cho SK, Roughley PJ, Linhardt RJ, Hecht AC, Iatridis JC. Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability. The spine journal : official journal of the North American Spine Society 2015 May; 15(5).
Long RG, Bürki A, Zysset P, Eglin D, Grijpma DW, Blanquer SB, Hecht AC, Iatridis JC. Mechanical restoration and failure analyses of a hydrogel and scaffold composite strategy for annulus fibrosus repair. Acta biomaterialia 2016 Jan; 30.
Illien-Jünger S, Lu Y, Qureshi SA, Hecht AC, Cai W, Vlassara H, Striker GE, Iatridis JC. Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice. PloS one 2015; 10(2).
Cornejo MC, Cho SK, Giannarelli C, Iatridis JC, Purmessur D. Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2015 Mar; 23(3).
Lai A, Moon A, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht AC, Iatridis JC. Assessment of functional and behavioral changes sensitive to painful disc degeneration. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2015 May; 33(5).
Risbud MV, Schoepflin ZR, Mwale F, Kandel RA, Grad S, Iatridis JC, Sakai D, Hoyland JA. Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2015 Mar; 33(3).
Lai A, Moon A, Purmessur D, Skovrlj B, Laudier DM, Winkelstein BA, Cho SK, Hecht AC, Iatridis JC. Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo. The spine journal : official journal of the North American Spine Society 2015 Dec;.